ERD2_PLAF7
ID ERD2_PLAF7 Reviewed; 221 AA.
AC Q76NM1;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=ER lumen protein-retaining receptor;
GN Name=ERD2; ORFNames=PF13_0280;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
CC -!- FUNCTION: Required for the retention of luminal endoplasmic reticulum
CC proteins. Determines the specificity of the luminal ER protein
CC retention system. Also required for normal vesicular traffic through
CC the Golgi (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC membrane protein.
CC -!- SIMILARITY: Belongs to the ERD2 family. {ECO:0000305}.
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DR EMBL; AL844509; CAD52657.1; -; Genomic_DNA.
DR RefSeq; XP_001350248.1; XM_001350212.1.
DR AlphaFoldDB; Q76NM1; -.
DR SMR; Q76NM1; -.
DR STRING; 5833.PF13_0280; -.
DR PRIDE; Q76NM1; -.
DR EnsemblProtists; CAD52657; CAD52657; PF3D7_1353600.
DR GeneID; 813646; -.
DR KEGG; pfa:PF3D7_1353600; -.
DR VEuPathDB; PlasmoDB:PF3D7_1353600; -.
DR HOGENOM; CLU_057784_0_0_1; -.
DR InParanoid; Q76NM1; -.
DR OMA; AYTVYLM; -.
DR PhylomeDB; Q76NM1; -.
DR Reactome; R-PFA-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR Proteomes; UP000001450; Chromosome 13.
DR GO; GO:0005801; C:cis-Golgi network; IDA:GeneDB.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IDA:GeneDB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046923; F:ER retention sequence binding; IBA:GO_Central.
DR GO; GO:0005046; F:KDEL sequence binding; ISS:GeneDB.
DR GO; GO:0038023; F:signaling receptor activity; NAS:GeneDB.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0006621; P:protein retention in ER lumen; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR000133; ER_ret_rcpt.
DR PANTHER; PTHR10585; PTHR10585; 1.
DR Pfam; PF00810; ER_lumen_recept; 1.
DR PRINTS; PR00660; ERLUMENR.
DR PROSITE; PS00951; ER_LUMEN_RECEPTOR_1; 1.
DR PROSITE; PS00952; ER_LUMEN_RECEPTOR_2; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; ER-Golgi transport; Membrane; Protein transport;
KW Receptor; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..221
FT /note="ER lumen protein-retaining receptor"
FT /id="PRO_0000194165"
FT TOPO_DOM 1..2
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 3..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 22..35
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..61
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..99
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..120
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..152
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..183
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..221
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 221 AA; 26447 MW; 7F231ED6AAACB368 CRC64;
MNIFRLIGDI LHLVSMYILI MKLKKSKNCI GISCRMQELY LIVFLCRYID LFFVFVSFYN
TVMKITFILT IAYTIYLIRL KLPISQTYNR KVDNFKSEKY LIPPCLVLSL LTCKTYNLYN
ILWSFSIWLE SVAILPQLVL LEKQREVENI TSHYVITMGL YRAFYILNWI YRYFFDDKPY
INVVGWIGGL IQTLLYIDFF YYFALAKWYG KKLVLPFNGE V
