ID   ERD2_PLAFA              Reviewed;         221 AA.
AC   P33948;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=ER lumen protein-retaining receptor;
GN   Name=ERD2;
OS   Plasmodium falciparum.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5833;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=ITGZF6;
RX   PubMed=8223485; DOI=10.1002/j.1460-2075.1993.tb06165.x;
RA   Elmendorf H.G., Haldar K.;
RT   "Identification and localization of ERD2 in the malaria parasite Plasmodium
RT   falciparum: separation from sites of sphingomyelin synthesis and
RT   implications for organization of the Golgi.";
RL   EMBO J. 12:4763-4773(1993).
CC   -!- FUNCTION: Required for the retention of luminal endoplasmic reticulum
CC       proteins. Determines the specificity of the luminal ER protein
CC       retention system. Also required for normal vesicular traffic through
CC       the Golgi (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the ERD2 family. {ECO:0000305}.
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DR   EMBL; X74869; CAA52861.1; -; mRNA.
DR   EMBL; Z26043; CAA81128.1; -; mRNA.
DR   PIR; S39609; S39609.
DR   AlphaFoldDB; P33948; -.
DR   SMR; P33948; -.
DR   EnsemblProtists; CAD52657; CAD52657; PF3D7_1353600.
DR   VEuPathDB; PlasmoDB:PF3D7_1353600; -.
DR   VEuPathDB; PlasmoDB:Pf7G8-2_000456100; -.
DR   VEuPathDB; PlasmoDB:Pf7G8_130058200; -.
DR   VEuPathDB; PlasmoDB:PfCD01_130059300; -.
DR   VEuPathDB; PlasmoDB:PfDd2_130059500; -.
DR   VEuPathDB; PlasmoDB:PfGA01_130059800; -.
DR   VEuPathDB; PlasmoDB:PfGB4_130059600; -.
DR   VEuPathDB; PlasmoDB:PfGN01_130060400; -.
DR   VEuPathDB; PlasmoDB:PfHB3_130060100; -.
DR   VEuPathDB; PlasmoDB:PfIT_130059000; -.
DR   VEuPathDB; PlasmoDB:PfKE01_130059300; -.
DR   VEuPathDB; PlasmoDB:PfKH01_130057700; -.
DR   VEuPathDB; PlasmoDB:PfKH02_130056600; -.
DR   VEuPathDB; PlasmoDB:PfML01_130057800; -.
DR   VEuPathDB; PlasmoDB:PfNF135_130057900; -.
DR   VEuPathDB; PlasmoDB:PfNF166_130058600; -.
DR   VEuPathDB; PlasmoDB:PfNF54_130058300; -.
DR   VEuPathDB; PlasmoDB:PfSD01_130060400; -.
DR   VEuPathDB; PlasmoDB:PfSN01_130056700; -.
DR   VEuPathDB; PlasmoDB:PfTG01_130059400; -.
DR   OMA; AYTVYLM; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046923; F:ER retention sequence binding; IEA:InterPro.
DR   GO; GO:0006621; P:protein retention in ER lumen; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000133; ER_ret_rcpt.
DR   PANTHER; PTHR10585; PTHR10585; 1.
DR   Pfam; PF00810; ER_lumen_recept; 1.
DR   PRINTS; PR00660; ERLUMENR.
DR   PROSITE; PS00951; ER_LUMEN_RECEPTOR_1; 1.
DR   PROSITE; PS00952; ER_LUMEN_RECEPTOR_2; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; ER-Golgi transport; Membrane; Protein transport;
KW   Receptor; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..221
FT                   /note="ER lumen protein-retaining receptor"
FT                   /id="PRO_0000194166"
FT   TOPO_DOM        1..2
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        3..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        22..35
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        53..61
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        81..99
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        114..120
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        141..152
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        172..183
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        204..221
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   221 AA;  26447 MW;  7F231ED6AAACB368 CRC64;
     MNIFRLIGDI LHLVSMYILI MKLKKSKNCI GISCRMQELY LIVFLCRYID LFFVFVSFYN
     TVMKITFILT IAYTIYLIRL KLPISQTYNR KVDNFKSEKY LIPPCLVLSL LTCKTYNLYN
     ILWSFSIWLE SVAILPQLVL LEKQREVENI TSHYVITMGL YRAFYILNWI YRYFFDDKPY
     INVVGWIGGL IQTLLYIDFF YYFALAKWYG KKLVLPFNGE V