ID   ERD2_SCHPO              Reviewed;         212 AA.
AC   O94270;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 127.
DE   RecName: Full=ER lumen protein-retaining receptor;
GN   Name=erd2; ORFNames=SPBP8B7.22;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Required for the retention of luminal endoplasmic reticulum
CC       proteins. Determines the specificity of the luminal ER protein
CC       retention system. Also required for normal vesicular traffic through
CC       the Golgi (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the ERD2 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAA21807.1; -; Genomic_DNA.
DR   PIR; T40816; T40816.
DR   RefSeq; NP_596529.1; NM_001022450.2.
DR   AlphaFoldDB; O94270; -.
DR   SMR; O94270; -.
DR   STRING; 4896.SPBP8B7.22.1; -.
DR   PaxDb; O94270; -.
DR   EnsemblFungi; SPBP8B7.22.1; SPBP8B7.22.1:pep; SPBP8B7.22.
DR   GeneID; 2540214; -.
DR   KEGG; spo:SPBP8B7.22; -.
DR   PomBase; SPBP8B7.22; erd2.
DR   VEuPathDB; FungiDB:SPBP8B7.22; -.
DR   eggNOG; KOG3106; Eukaryota.
DR   HOGENOM; CLU_057784_0_0_1; -.
DR   InParanoid; O94270; -.
DR   OMA; AYTVYLM; -.
DR   PhylomeDB; O94270; -.
DR   Reactome; R-SPO-6807878; COPI-mediated anterograde transport.
DR   Reactome; R-SPO-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR   PRO; PR:O94270; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005801; C:cis-Golgi network; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR   GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISO:PomBase.
DR   GO; GO:0046923; F:ER retention sequence binding; IBA:GO_Central.
DR   GO; GO:0045015; F:HDEL sequence binding; ISO:PomBase.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISO:PomBase.
DR   GO; GO:0006886; P:intracellular protein transport; IC:PomBase.
DR   GO; GO:0006621; P:protein retention in ER lumen; ISO:PomBase.
DR   InterPro; IPR000133; ER_ret_rcpt.
DR   PANTHER; PTHR10585; PTHR10585; 1.
DR   Pfam; PF00810; ER_lumen_recept; 1.
DR   PRINTS; PR00660; ERLUMENR.
DR   PROSITE; PS00951; ER_LUMEN_RECEPTOR_1; 1.
DR   PROSITE; PS00952; ER_LUMEN_RECEPTOR_2; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; ER-Golgi transport; Membrane; Protein transport;
KW   Receptor; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..212
FT                   /note="ER lumen protein-retaining receptor"
FT                   /id="PRO_0000194170"
FT   TOPO_DOM        1..2
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        3..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        22..35
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        54..61
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        81..96
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        111..117
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        138..149
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        169..178
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        200..212
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   212 AA;  24725 MW;  633F1E598D5DC83D CRC64;
     MTFFSALGDM AHLAAIFLLL HRMKKSKTCS GLSLKSHLLF LLVYVTRYLN LFWRYKSLYY
     FLMRIVFIAS ESYICYLMLM TLRPTYDKRL DTFRTEYILG GCAVLALIYP TSYTISNILW
     TFSIWLESVA ILPQLFMLQR SGETESLTAH YLFAMCLYRG LYIPHWIYRI AVHKKVIGVA
     ILAGIIQTVL YGDFAVVYRR TVLQGKKFRL PA