ERD2_YEAST
ID ERD2_YEAST Reviewed; 219 AA.
AC P18414; D6VPV8;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=ER lumen protein-retaining receptor {ECO:0000305};
DE AltName: Full=Endoplasmic reticulum retention defective protein 2 {ECO:0000303|PubMed:2178921};
DE AltName: Full=HDEL receptor;
GN Name=ERD2 {ECO:0000303|PubMed:2178921, ECO:0000303|PubMed:2194670};
GN OrderedLocusNames=YBL040C {ECO:0000312|SGD:S000000136}; ORFNames=YBL0408;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC STRAIN=SEY2102;
RX PubMed=2194670; DOI=10.1016/0092-8674(90)90698-e;
RA Semenza J.C., Hardwick K.G., Dean N., Pelham H.R.B.;
RT "ERD2, a yeast gene required for the receptor-mediated retrieval of luminal
RT ER proteins from the secretory pathway.";
RL Cell 61:1349-1357(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7871888; DOI=10.1002/yea.320101113;
RA de Wergifosse P., Jacques B., Jonniaux J.-L., Purnelle B., Skala J.,
RA Goffeau A.;
RT "The sequence of a 22.4 kb DNA fragment from the left arm of yeast
RT chromosome II reveals homologues to bacterial proline synthetase and murine
RT alpha-adaptin, as well as a new permease and a DNA-binding protein.";
RL Yeast 10:1489-1496(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA Mewes H.-W., Kleine K.;
RT "Complete DNA sequence of yeast chromosome II.";
RL EMBO J. 13:5795-5809(1994).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP FUNCTION.
RX PubMed=2194671; DOI=10.1016/0092-8674(90)90699-f;
RA Lewis M.J., Sweet D.J., Pelham H.R.B.;
RT "The ERD2 gene determines the specificity of the luminal ER protein
RT retention system.";
RL Cell 61:1359-1363(1990).
RN [6]
RP FUNCTION.
RX PubMed=2178921; DOI=10.1002/j.1460-2075.1990.tb08154.x;
RA Hardwick K., Lewis M., Semenza J., Dean N., Pelham H.;
RT "ERD1, a yeast gene required for the retention of luminal endoplasmic
RT reticulum proteins, affects glycoprotein processing in the Golgi
RT apparatus.";
RL EMBO J. 9:623-630(1990).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=29897761; DOI=10.1021/acs.jproteome.8b00032;
RA He C., Jia C., Zhang Y., Xu P.;
RT "Enrichment-based proteogenomics identifies microproteins, missing
RT proteins, and novel smORFs in Saccharomyces cerevisiae.";
RL J. Proteome Res. 17:2335-2344(2018).
CC -!- FUNCTION: Required for the retention of luminal endoplasmic reticulum
CC proteins. Determines the specificity of the luminal ER protein
CC retention system. Also required for normal vesicular traffic through
CC the Golgi. This receptor strongly recognizes H-D-E-L and weakly
CC recognizes D-D-E-L and K-D-E-L. {ECO:0000269|PubMed:2194670,
CC ECO:0000269|PubMed:2194671, ECO:0000269|PubMed:7871888}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:2194670}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the ERD2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA55054.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M34777; AAA68907.1; -; Genomic_DNA.
DR EMBL; X78214; CAA55054.1; ALT_INIT; Genomic_DNA.
DR EMBL; Z35801; CAA84860.1; -; Genomic_DNA.
DR EMBL; BK006936; DAA07078.1; -; Genomic_DNA.
DR PIR; A35617; A35617.
DR RefSeq; NP_009513.1; NM_001178280.1.
DR AlphaFoldDB; P18414; -.
DR SMR; P18414; -.
DR BioGRID; 32657; 129.
DR DIP; DIP-7718N; -.
DR IntAct; P18414; 40.
DR MINT; P18414; -.
DR STRING; 4932.YBL040C; -.
DR PaxDb; P18414; -.
DR PRIDE; P18414; -.
DR EnsemblFungi; YBL040C_mRNA; YBL040C; YBL040C.
DR GeneID; 852240; -.
DR KEGG; sce:YBL040C; -.
DR SGD; S000000136; ERD2.
DR VEuPathDB; FungiDB:YBL040C; -.
DR eggNOG; KOG3106; Eukaryota.
DR GeneTree; ENSGT00390000004010; -.
DR HOGENOM; CLU_057784_0_0_1; -.
DR InParanoid; P18414; -.
DR OMA; AYTVYLM; -.
DR BioCyc; YEAST:G3O-28941-MON; -.
DR Reactome; R-SCE-6807878; COPI-mediated anterograde transport.
DR Reactome; R-SCE-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR PRO; PR:P18414; -.
DR Proteomes; UP000002311; Chromosome II.
DR RNAct; P18414; protein.
DR GO; GO:0005801; C:cis-Golgi network; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IDA:SGD.
DR GO; GO:0046923; F:ER retention sequence binding; IBA:GO_Central.
DR GO; GO:0045015; F:HDEL sequence binding; IMP:SGD.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IMP:SGD.
DR GO; GO:0006621; P:protein retention in ER lumen; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR000133; ER_ret_rcpt.
DR PANTHER; PTHR10585; PTHR10585; 1.
DR Pfam; PF00810; ER_lumen_recept; 1.
DR PRINTS; PR00660; ERLUMENR.
DR PROSITE; PS00951; ER_LUMEN_RECEPTOR_1; 1.
DR PROSITE; PS00952; ER_LUMEN_RECEPTOR_2; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; ER-Golgi transport; Membrane; Protein transport;
KW Receptor; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..219
FT /note="ER lumen protein-retaining receptor"
FT /id="PRO_0000194171"
FT TOPO_DOM 1..5
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 27..37
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..98
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 99..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 117..118
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..152
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 174..185
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..219
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
SQ SEQUENCE 219 AA; 25763 MW; 9F19C47F81C40182 CRC64;
MNPFRILGDL SHLTSILILI HNIKTTRYIE GISFKTQTLY ALVFITRYLD LLTFHWVSLY
NALMKIFFIV STAYIVVLLQ GSKRTNTIAY NEMLMHDTFK IQHLLIGSAL MSVFFHHKFT
FLELAWSFSV WLESVAILPQ LYMLSKGGKT RSLTVHYIFA MGLYRALYIP NWIWRYSTED
KKLDKIAFFA GLLQTLLYSD FFYIYYTKVI RGKGFKLPK
