ERD6_ARATH
ID ERD6_ARATH Reviewed; 496 AA.
AC O04036; O65799;
DT 14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 3.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Sugar transporter ERD6;
DE AltName: Full=Early-responsive to dehydration protein 6;
DE AltName: Full=Sugar transporter-like protein 1;
GN Name=ERD6; Synonyms=SUGTL1; OrderedLocusNames=At1g08930; ORFNames=F7G19.19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RX PubMed=9545564; DOI=10.1016/s0005-2736(98)00007-8;
RA Kiyosue T., Abe H., Yamaguchi-Shinozaki K., Shinozaki K.;
RT "ERD6, a cDNA clone for an early dehydration-induced gene of Arabidopsis,
RT encodes a putative sugar transporter.";
RL Biochim. Biophys. Acta 1370:187-191(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Gy I., Kreis M., Lecharny A.;
RT "A novel multigene family in Arabidopsis thaliana coding for putative sugar
RT transporters.";
RL Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [6]
RP GENE FAMILY.
RX PubMed=16923188; DOI=10.1186/1471-2148-6-64;
RA Johnson D.A., Hill J.P., Thomas M.A.;
RT "The monosaccharide transporter gene family in land plants is ancient and
RT shows differential subfamily expression and expansion across lineages.";
RL BMC Evol. Biol. 6:64-64(2006).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-256, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
RN [8]
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=19901034; DOI=10.1074/jbc.m109.054288;
RA Yamada K., Osakabe Y., Mizoi J., Nakashima K., Fujita Y., Shinozaki K.,
RA Yamaguchi-Shinozaki K.;
RT "Functional analysis of an Arabidopsis thaliana abiotic stress-inducible
RT facilitated diffusion transporter for monosaccharides.";
RL J. Biol. Chem. 285:1138-1146(2010).
CC -!- FUNCTION: Sugar transporter. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in both shoots and roots. In roots,
CC expressed in epidermal cells and especially strongly in cortex cells.
CC In flowers, expressed in sepals. {ECO:0000269|PubMed:19901034}.
CC -!- INDUCTION: By dehydration and cold treatment (PubMed:9545564). By
CC drought and high salinity conditions, with maximal expression after 1
CC and 2 hours of exposure to these conditions. Expression in leaves
CC decreases after exposure to the high salinity and abscisic acid (ABA)
CC treatment, but expression in roots remain at a constant level
CC (PubMed:19901034). {ECO:0000269|PubMed:19901034,
CC ECO:0000269|PubMed:9545564}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB70420.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; D89051; BAA25989.1; -; mRNA.
DR EMBL; AJ249967; CAB64732.1; -; mRNA.
DR EMBL; AC000106; AAB70420.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28370.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28371.1; -; Genomic_DNA.
DR EMBL; BT008661; AAP40473.1; -; mRNA.
DR PIR; B86221; B86221.
DR PIR; T52132; T52132.
DR RefSeq; NP_001031006.1; NM_001035929.1.
DR RefSeq; NP_563830.1; NM_100765.5.
DR AlphaFoldDB; O04036; -.
DR SMR; O04036; -.
DR BioGRID; 22655; 3.
DR IntAct; O04036; 2.
DR STRING; 3702.AT1G08930.1; -.
DR TCDB; 2.A.1.1.97; the major facilitator superfamily (mfs).
DR iPTMnet; O04036; -.
DR PaxDb; O04036; -.
DR PRIDE; O04036; -.
DR ProteomicsDB; 220669; -.
DR EnsemblPlants; AT1G08930.1; AT1G08930.1; AT1G08930.
DR EnsemblPlants; AT1G08930.2; AT1G08930.2; AT1G08930.
DR GeneID; 837414; -.
DR Gramene; AT1G08930.1; AT1G08930.1; AT1G08930.
DR Gramene; AT1G08930.2; AT1G08930.2; AT1G08930.
DR KEGG; ath:AT1G08930; -.
DR Araport; AT1G08930; -.
DR TAIR; locus:2036084; AT1G08930.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_001265_30_5_1; -.
DR InParanoid; O04036; -.
DR OMA; SSFIWRF; -.
DR OrthoDB; 430696at2759; -.
DR PhylomeDB; O04036; -.
DR PRO; PR:O04036; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; O04036; baseline and differential.
DR Genevisible; O04036; AT.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; ISS:TAIR.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0009737; P:response to abscisic acid; IEP:TAIR.
DR GO; GO:0009409; P:response to cold; IDA:UniProtKB.
DR GO; GO:0009651; P:response to salt stress; IEP:TAIR.
DR GO; GO:0009414; P:response to water deprivation; IDA:UniProtKB.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR CDD; cd17358; MFS_GLUT6_8_Class3_like; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR044775; MFS_ERD6/Tret1-like.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Stress response;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..496
FT /note="Sugar transporter ERD6"
FT /id="PRO_0000259853"
FT TRANSMEM 58..78
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 329..349
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..384
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 394..414
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 430..450
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 456..476
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT MOD_RES 256
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19376835"
SQ SEQUENCE 496 AA; 54355 MW; 25CC9D21ADC155CC CRC64;
MERQKSMEKG LLRKSLSIRE RKFPNEDAFL ESGLSRKSPR EVKKPQNDDG ECRVTASVFL
STFVAVSGSF CTGCGVGFSS GAQAGITKDL SLSVAEYSMF GSILTLGGLI GAVFSGKVAD
VLGRKRTMLF CEFFCITGWL CVALAQNAMW LDCGRLLLGI GVGIFSYVIP VYIAEIAPKH
VRGSFVFANQ LMQNCGISLF FIIGNFIPWR LLTVVGLVPC VFHVFCLFFI PESPRWLAKL
GRDKECRSSL QRLRGSDVDI SREANTIRDT IDMTENGGET KMSELFQRRY AYPLIIGVGL
MFLQQLCGSS GVTYYASSLF NKGGFPSAIG TSVIATIMVP KAMLATVLVD KMGRRTLLMA
SCSAMGLSAL LLSVSYGFQS FGILPELTPI FTCIGVLGHI VSFAMGMGGL PWIIMAEIFP
MNVKVSAGTL VTVTNWLFGW IITYTFNFML EWNASGMFLI FSMVSASSIV FIYFLVPETK
GRSLEEIQAL LNNSVQ
