ERDL2_ARATH
ID ERDL2_ARATH Reviewed; 462 AA.
AC Q4F7G0; O04040; Q94F32; Q9SCW8;
DT 14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Sugar transporter ERD6-like 2;
DE AltName: Full=Sugar transporter-like protein 3;
GN Name=SUGTL3; OrderedLocusNames=At1g08900; ORFNames=F7G19.22;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Reinders A., Ward J.M.;
RT "Functional analysis of sugar transporters in the model plant Arabidopsis
RT thaliana.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 46-298.
RA Gy I., Kreis M., Lecharny A.;
RT "A novel multigene family in Arabidopsis thaliana coding for putative sugar
RT transporters.";
RL Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY.
RX PubMed=16923188; DOI=10.1186/1471-2148-6-64;
RA Johnson D.A., Hill J.P., Thomas M.A.;
RT "The monosaccharide transporter gene family in land plants is ancient and
RT shows differential subfamily expression and expansion across lineages.";
RL BMC Evol. Biol. 6:64-64(2006).
CC -!- FUNCTION: Sugar transporter. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q4F7G0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q4F7G0-2; Sequence=VSP_021543, VSP_021544;
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB70414.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; DQ105587; AAZ15015.1; -; mRNA.
DR EMBL; AC000106; AAB70414.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28363.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28364.1; -; Genomic_DNA.
DR EMBL; AF386931; AAK62376.1; -; mRNA.
DR EMBL; AY072458; AAL66873.1; -; mRNA.
DR EMBL; AJ249969; CAB64734.1; -; mRNA.
DR PIR; G86220; G86220.
DR RefSeq; NP_001077495.1; NM_001084026.2. [Q4F7G0-1]
DR RefSeq; NP_563828.2; NM_100762.2. [Q4F7G0-1]
DR AlphaFoldDB; Q4F7G0; -.
DR SMR; Q4F7G0; -.
DR STRING; 3702.AT1G08900.2; -.
DR PaxDb; Q4F7G0; -.
DR PRIDE; Q4F7G0; -.
DR EnsemblPlants; AT1G08900.1; AT1G08900.1; AT1G08900. [Q4F7G0-1]
DR EnsemblPlants; AT1G08900.2; AT1G08900.2; AT1G08900. [Q4F7G0-1]
DR GeneID; 837411; -.
DR Gramene; AT1G08900.1; AT1G08900.1; AT1G08900. [Q4F7G0-1]
DR Gramene; AT1G08900.2; AT1G08900.2; AT1G08900. [Q4F7G0-1]
DR KEGG; ath:AT1G08900; -.
DR Araport; AT1G08900; -.
DR TAIR; locus:2036009; AT1G08900.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_001265_30_5_1; -.
DR InParanoid; Q4F7G0; -.
DR PhylomeDB; Q4F7G0; -.
DR PRO; PR:Q4F7G0; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q4F7G0; baseline and differential.
DR Genevisible; Q4F7G0; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR CDD; cd17358; MFS_GLUT6_8_Class3_like; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR044775; MFS_ERD6/Tret1-like.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..462
FT /note="Sugar transporter ERD6-like 2"
FT /id="PRO_0000259851"
FT TRANSMEM 23..43
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..377
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 397..417
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 423..443
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT VAR_SEQ 263..264
FT /note="IG -> FR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14593172"
FT /id="VSP_021543"
FT VAR_SEQ 265..462
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14593172"
FT /id="VSP_021544"
SQ SEQUENCE 462 AA; 51053 MW; 1364D2611B760AC2 CRC64;
MESERLESHL LNKQEEEASS FTSGLLLSTS VVVAGSFCYG CAMSYSSPAQ SKIMEELGLS
VADYSFFTSV MTLGGMITAV FSGKISALVG RRQTMWISDV CCIFGWLAVA FAHDIIMLNT
GRLFLGFGVG LISYVVPVYI AEITPKTFRG GFSYSNQLLQ CLGISLMFFT GNFFHWRTLA
LLSAIPSAFQ VICLFFIPES PRWLAMYGQD QELEVSLKKL RGENSDILKE AAEIRETVEI
SRKESQSGIR DLFHIGNAHS LIIGLGLMLL QQFCGSAAIS AYAARIFDKA GFPSDIGTTI
LAVILIPQSI VVMLTVDRWG RRPLLMISSI GMCICSFFIG LSYYLQKNGE FQKLCSVMLI
VGLVGYVSSF GIGLGGLPWV IMSEIFPVNV KITAGSLVTM SNWFFNWIII YSFNFMIQWS
ASGTYFIFSG VSLVTIVFIW TLVPETKGRT LEEIQTSLVR LS
