ERDL5_ARATH
ID ERDL5_ARATH Reviewed; 470 AA.
AC Q3ECP7; Q8H197; Q940K3; Q9ZVM0;
DT 14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Sugar transporter ERD6-like 5;
GN OrderedLocusNames=At1g54730; ORFNames=T22H22.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=16923188; DOI=10.1186/1471-2148-6-64;
RA Johnson D.A., Hill J.P., Thomas M.A.;
RT "The monosaccharide transporter gene family in land plants is ancient and
RT shows differential subfamily expression and expansion across lineages.";
RL BMC Evol. Biol. 6:64-64(2006).
CC -!- FUNCTION: Sugar transporter. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q3ECP7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3ECP7-2; Sequence=VSP_021546, VSP_021549, VSP_021550;
CC Name=3;
CC IsoId=Q3ECP7-3; Sequence=VSP_021546, VSP_021547, VSP_021548;
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC64898.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAN15437.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AC005388; AAC64898.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE33139.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33141.1; -; Genomic_DNA.
DR EMBL; AY054504; AAK96695.1; -; mRNA.
DR EMBL; BT000118; AAN15437.1; ALT_FRAME; mRNA.
DR EMBL; BT025017; ABE02392.1; -; mRNA.
DR PIR; D96589; D96589.
DR RefSeq; NP_564666.1; NM_104349.2. [Q3ECP7-3]
DR RefSeq; NP_850964.1; NM_180633.2. [Q3ECP7-1]
DR AlphaFoldDB; Q3ECP7; -.
DR SMR; Q3ECP7; -.
DR BioGRID; 27139; 7.
DR IntAct; Q3ECP7; 7.
DR STRING; 3702.AT1G54730.2; -.
DR PaxDb; Q3ECP7; -.
DR PRIDE; Q3ECP7; -.
DR ProteomicsDB; 220671; -. [Q3ECP7-1]
DR EnsemblPlants; AT1G54730.1; AT1G54730.1; AT1G54730. [Q3ECP7-3]
DR EnsemblPlants; AT1G54730.2; AT1G54730.2; AT1G54730. [Q3ECP7-1]
DR GeneID; 841914; -.
DR Gramene; AT1G54730.1; AT1G54730.1; AT1G54730. [Q3ECP7-3]
DR Gramene; AT1G54730.2; AT1G54730.2; AT1G54730. [Q3ECP7-1]
DR KEGG; ath:AT1G54730; -.
DR Araport; AT1G54730; -.
DR TAIR; locus:2199539; AT1G54730.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_001265_30_5_1; -.
DR InParanoid; Q3ECP7; -.
DR OMA; MINPLYV; -.
DR OrthoDB; 430696at2759; -.
DR PhylomeDB; Q3ECP7; -.
DR PRO; PR:Q3ECP7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q3ECP7; baseline and differential.
DR Genevisible; Q3ECP7; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR CDD; cd17358; MFS_GLUT6_8_Class3_like; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR044775; MFS_ERD6/Tret1-like.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..470
FT /note="Sugar transporter ERD6-like 5"
FT /id="PRO_0000259855"
FT TRANSMEM 32..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 369..389
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 404..424
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 430..450
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..82
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14593172, ECO:0000303|Ref.4"
FT /id="VSP_021546"
FT VAR_SEQ 144..149
FT /note="PVYIAE -> KSINSS (in isoform 3)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_021547"
FT VAR_SEQ 150..470
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_021548"
FT VAR_SEQ 392..414
FT /note="IFPIDIKGSAGSLVTVVSWVGSW -> VSNIHKNSLVLNILLYLIIRSMS
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14593172"
FT /id="VSP_021549"
FT VAR_SEQ 415..470
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14593172"
FT /id="VSP_021550"
FT CONFLICT 269
FT /note="V -> I (in Ref. 3; AAN15437)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 470 AA; 50740 MW; 73A74F534EF3A0F9 CRC64;
MRGEIDEANL APETSLINKE NQDSSATITT TLLLTTFVAV SGSFVFGSAI GYSSPVQSDL
TKELNLSVAE YSLFGSILTI GAMIGAAMSG RIADMIGRRA TMGFSEMFCI LGWLAIYLSK
VAIWLDVGRF LVGYGMGVFS FVVPVYIAEI TPKGLRGGFT TVHQLLICLG VSVTYLLGSF
IGWRILALIG MIPCVVQMMG LFVIPESPRW LAKVGKWEEF EIALQRLRGE SADISYESNE
IKDYTRRLTD LSEGSIVDLF QPQYAKSLVV GVGLMVLQQF GGVNGIAFYA SSIFESAGVS
SKIGMIAMVV VQIPMTTLGV LLMDKSGRRP LLLISATGTC IGCFLVGLSF SLQFVKQLSG
DASYLALTGV LVYTGSFSLG MGGIPWVIMS EIFPIDIKGS AGSLVTVVSW VGSWIISFTF
NFLMNWNPAG TFYVFATVCG ATVIFVAKLV PETKGRTLEE IQYSIGYVEL
