ID   EREA_ECOLX              Reviewed;         406 AA.
AC   P07684; Q84FW7;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2004, sequence version 2.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Erythromycin esterase type I;
DE            EC=3.1.1.-;
GN   Name=ereA;
OS   Escherichia coli.
OG   Plasmid pIP1100.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BM2195;
RX   PubMed=3899861; DOI=10.1016/0378-1119(85)90005-8;
RA   Ounissi H., Courvalin P.;
RT   "Nucleotide sequence of the gene ereA encoding the erythromycin esterase in
RT   Escherichia coli.";
RL   Gene 35:271-278(1985).
RN   [2]
RP   SEQUENCE REVISION TO N-TERMINUS.
RC   STRAIN=BM2195;
RX   PubMed=14506050; DOI=10.1128/aac.47.10.3326-3331.2003;
RA   Biskri L., Mazel D.;
RT   "Erythromycin esterase gene ere(A) is located in a functional gene cassette
RT   in an unusual class 2 integron.";
RL   Antimicrob. Agents Chemother. 47:3326-3331(2003).
CC   -!- FUNCTION: This enzyme confers resistance to erythromycin through
CC       inactivation by hydrolyzing the lactone ring of the antibiotic.
CC   -!- MISCELLANEOUS: Erythromycin esterase type I and type II share no
CC       significant homology except for the region from AA 270 to 300.
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DR   EMBL; AY183453; AAO38247.1; -; Genomic_DNA.
DR   PIR; A24027; A24027.
DR   RefSeq; WP_032490532.1; NG_047765.1.
DR   AlphaFoldDB; P07684; -.
DR   SMR; P07684; -.
DR   KEGG; ag:AAO38247; -.
DR   GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd14728; Ere-like; 1.
DR   InterPro; IPR007815; Emycin_Estase.
DR   InterPro; IPR016273; Emycin_Estase_proteobac.
DR   Pfam; PF05139; Erythro_esteras; 1.
DR   PIRSF; PIRSF000880; Eryth_est; 1.
PE   4: Predicted;
KW   Antibiotic resistance; Hydrolase; Plasmid; Serine esterase.
FT   CHAIN           1..406
FT                   /note="Erythromycin esterase type I"
FT                   /id="PRO_0000087010"
SQ   SEQUENCE   406 AA;  44783 MW;  F6534E559958FC79 CRC64;
     MTWRTTRTLL QPQKLDFNEF EILTSVIEGA RIVGIGEGAH FVAEFSLARA SLIRYLVERH
     EFNAIGLECG AIQASRLSEW LNSTAGAHEL ERFSDTLTFS VYGSVLIWLK SYLRESGRKL
     QLVGIDLPNT LNPRDDLAQL AEIIQLIDHL MKPHVDMLTH LLASIDGQSA VISSAKWGEL
     ETARQEKAIS GVTRLKLRLA SLAPVLKKHV NSDLFRKASD RIESIEYTLE TLRIMKTFFD
     GTSLEGDTSV RDSYMAGVVD GMVRANPDVK IILLAHNNHL QKTPVSFSGE LTAVPMGQHL
     AERVNYRAIA FTHLGPTVPE MHFPSPKSPL GFSVVTTPAD AIREDSMEQY VIDACGTENS
     CLTLTDAPME AKRMRSQSAS VETKLSEAFD AIVCVTSAGK DSLVAL