ID   EREB_ECOLX              Reviewed;         419 AA.
AC   P05789;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Erythromycin esterase type II;
DE            EC=3.1.1.-;
GN   Name=ereB;
OS   Escherichia coli.
OG   Plasmid pIP1527.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3523438; DOI=10.1093/nar/14.12.4987;
RA   Arthur M., Autissier D., Courvalin P.;
RT   "Analysis of the nucleotide sequence of the ereB gene encoding the
RT   erythromycin esterase type II.";
RL   Nucleic Acids Res. 14:4987-4999(1986).
CC   -!- FUNCTION: This enzyme confers resistance to erythromycin through
CC       inactivation by hydrolyzing the lactone ring of the antibiotic.
CC   -!- MISCELLANEOUS: Erythromycin esterase type I and type II share no
CC       significant homology except for the region from 279 to 309.
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DR   EMBL; X03988; CAA27626.1; -; Genomic_DNA.
DR   PIR; A24381; ESECRM.
DR   RefSeq; WP_032488343.1; NZ_NNXO01000082.1.
DR   AlphaFoldDB; P05789; -.
DR   SMR; P05789; -.
DR   KEGG; ag:CAA27626; -.
DR   GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd14728; Ere-like; 1.
DR   InterPro; IPR007815; Emycin_Estase.
DR   InterPro; IPR016273; Emycin_Estase_proteobac.
DR   Pfam; PF05139; Erythro_esteras; 1.
DR   PIRSF; PIRSF000880; Eryth_est; 1.
PE   4: Predicted;
KW   Antibiotic resistance; Hydrolase; Plasmid; Serine esterase.
FT   CHAIN           1..419
FT                   /note="Erythromycin esterase type II"
FT                   /id="PRO_0000087011"
SQ   SEQUENCE   419 AA;  48173 MW;  BCBD7A565DBC9B4A CRC64;
     MRFEEWVKDK HIPFKLNHPD DNYDDFKPLR KIIGDTRVVA LGENSHFIKE FFLLRHTLLR
     FFIEDLGFTT FAFEFGFAEG QIINNWIHGQ GTDDEIGRFL KHFYYPEELK TTFLWLREYN
     KAAKEKITFL GIDIPRNGGS YLPNMEIVHD FFRTADKEAL HIIDDAFNIA KKIDYFSTSQ
     AALNLHELTD SEKCRLTSQL ARVKVRLEAM APIHIEKYGI DKYETILHYA NGMIYLDYNI
     QAMSGFISGG GMQGDMGAKD KYMADSVLWH LKNPQSEQKV IVVAHNAHIQ KTPILYDGFL
     SCLPMGQRLK NAIGDDYMSL GITSYSGHTA ALYPEVDTKY GFRVDNFQLQ EPNEGSVEKA
     ISGCGVTNSF VFFRNIPEDL QSIPNMIRFD SIYMKAELEK AFDGIFQIEK SSVSEVVYE