AGP7_ARATH
ID AGP7_ARATH Reviewed; 130 AA.
AC Q8LG54; Q9FKQ0;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 2.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Classical arabinogalactan protein 7;
DE Flags: Precursor;
GN Name=AGP7; OrderedLocusNames=At5g65390; ORFNames=MNA5.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 108-130, PROTEIN SEQUENCE OF 22-37,
RP HYDROXYLATION AT PRO-24; PRO-26; PRO-28; PRO-35 AND PRO-36, AND
RP PYROGLUTAMATE FORMATION AT GLN-22.
RC STRAIN=cv. Columbia;
RX PubMed=11006345; DOI=10.2307/3871187;
RA Schultz C.J., Johnson K.L., Currie G., Bacic A.;
RT "The classical arabinogalactan protein gene family of Arabidopsis.";
RL Plant Cell 12:1751-1767(2000).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12177459; DOI=10.1104/pp.003459;
RA Schultz C.J., Rumsewicz M.P., Johnson K.L., Jones B.J., Gaspar Y.M.,
RA Bacic A.;
RT "Using genomic resources to guide research directions. The arabinogalactan
RT protein gene family as a test case.";
RL Plant Physiol. 129:1448-1463(2002).
CC -!- FUNCTION: Proteoglycan that seems to be implicated in diverse
CC developmental roles such as differentiation, cell-cell recognition,
CC embryogenesis and programmed cell death.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}.
CC -!- PTM: O-glycosylated on hydroxyprolines; noncontiguous hydroxylproline
CC residues are glycosylated with arabinogalactan.
CC -!- SIMILARITY: Belongs to the classical AGP family. {ECO:0000305}.
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DR EMBL; AB011479; BAB11561.1; -; Genomic_DNA.
DR EMBL; CP002688; AED98046.1; -; Genomic_DNA.
DR EMBL; AY050361; AAK91378.1; -; mRNA.
DR EMBL; AY094049; AAM16205.1; -; mRNA.
DR EMBL; AY084455; AAM61027.1; -; mRNA.
DR EMBL; AF195888; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_569011.1; NM_125937.3.
DR AlphaFoldDB; Q8LG54; -.
DR STRING; 3702.AT5G65390.1; -.
DR PaxDb; Q8LG54; -.
DR EnsemblPlants; AT5G65390.1; AT5G65390.1; AT5G65390.
DR GeneID; 836664; -.
DR Gramene; AT5G65390.1; AT5G65390.1; AT5G65390.
DR KEGG; ath:AT5G65390; -.
DR Araport; AT5G65390; -.
DR TAIR; locus:2168220; AT5G65390.
DR eggNOG; ENOG502SY2B; Eukaryota.
DR HOGENOM; CLU_149596_0_0_1; -.
DR InParanoid; Q8LG54; -.
DR OMA; SINKPIM; -.
DR PRO; PR:Q8LG54; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8LG54; baseline and differential.
DR Genevisible; Q8LG54; AT.
DR GO; GO:0031225; C:anchored component of membrane; TAS:TAIR.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR044959; AGP.
DR PANTHER; PTHR36321; PTHR36321; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Direct protein sequencing; Glycoprotein; GPI-anchor;
KW Hydroxylation; Lipoprotein; Membrane; Proteoglycan;
KW Pyrrolidone carboxylic acid; Reference proteome; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000269|PubMed:11006345"
FT CHAIN 22..106
FT /note="Classical arabinogalactan protein 7"
FT /id="PRO_0000268997"
FT PROPEP 107..130
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000268998"
FT REGION 22..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..90
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 22
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:11006345"
FT MOD_RES 24
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:11006345"
FT MOD_RES 26
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:11006345"
FT MOD_RES 28
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:11006345"
FT MOD_RES 35
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:11006345"
FT MOD_RES 36
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:11006345"
FT LIPID 106
FT /note="GPI-anchor amidated asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 24
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000255"
FT CARBOHYD 26
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000255"
FT CARBOHYD 28
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000255"
FT CARBOHYD 35
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000255"
FT CARBOHYD 36
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000255"
FT CONFLICT 92
FT /note="E -> D (in Ref. 4; AAM61027)"
FT /evidence="ECO:0000305"
FT CONFLICT 120
FT /note="V -> F (in Ref. 4; AAM61027)"
FT /evidence="ECO:0000305"
FT CONFLICT 123..124
FT /note="II -> VV (in Ref. 4; AAM61027)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 130 AA; 12510 MW; D6EB581F545B82E9 CRC64;
MNSKIIEAFF IVALFTTSCL AQAPAPSPTT TVTPPPVATP PPAATPAPTT TPPPAVSPAP
TSSPPSSAPS PSSDAPTASP PAPEGPGVSP GELAPTPSDA SAPPPNAALT NKAFVVGSLV
AAIIYAVVLA
