ERF12_ARATH
ID ERF12_ARATH Reviewed; 230 AA.
AC Q9SFE4; Q8LDL8;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Ethylene-responsive transcription factor ERF012;
DE AltName: Full=Dehydration response element-binding protein 26 {ECO:0000303|PubMed:21069430};
GN Name=ERF012; Synonyms=DREB26 {ECO:0000303|PubMed:21069430};
GN OrderedLocusNames=At1g21910; ORFNames=T26F17.14;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16407444; DOI=10.1104/pp.105.073783;
RA Nakano T., Suzuki K., Fujimura T., Shinshi H.;
RT "Genome-wide analysis of the ERF gene family in Arabidopsis and rice.";
RL Plant Physiol. 140:411-432(2006).
RN [7]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=21069430; DOI=10.1007/s11103-010-9711-7;
RA Krishnaswamy S., Verma S., Rahman M.H., Kav N.N.;
RT "Functional characterization of four APETALA2-family genes (RAP2.6,
RT RAP2.6L, DREB19 and DREB26) in Arabidopsis.";
RL Plant Mol. Biol. 75:107-127(2011).
RN [8]
RP FUNCTION.
RX PubMed=27137403; DOI=10.3390/plants2040769;
RA Kazama D., Itakura M., Kurusu T., Mitsuda N., Ohme-Takagi M., Tada Y.;
RT "Identification of chimeric repressors that confer salt and osmotic stress
RT tolerance in Arabidopsis.";
RL Plants (Basel) 2:769-785(2013).
CC -!- FUNCTION: Transcriptional activator involved in the regulation of plant
CC development and tolerance to abiotic stresses (PubMed:21069430).
CC Involved in salt and osmotic stress response pathways. May be regulated
CC by the stress-related genes RD29A, RD22, DREB1A or P5CS during stress
CC response (PubMed:27137403). Binds to the GCC-box pathogenesis-related
CC promoter element. May be involved in the regulation of gene expression
CC by stress factors and by components of stress signal transduction
CC pathways (By similarity). {ECO:0000250, ECO:0000269|PubMed:21069430,
CC ECO:0000269|PubMed:27137403}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00366,
CC ECO:0000269|PubMed:21069430}.
CC -!- TISSUE SPECIFICITY: Expressed cotyledons, ovules and seeds of immature
CC siliques. {ECO:0000269|PubMed:21069430}.
CC -!- INDUCTION: Induced by jasmonate (JA) and ethylene. Down-regulated by
CC freezing and heat stresses. {ECO:0000269|PubMed:21069430}.
CC -!- SIMILARITY: Belongs to the AP2/ERF transcription factor family. ERF
CC subfamily. {ECO:0000305}.
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DR EMBL; AC013482; AAF16532.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE30171.1; -; Genomic_DNA.
DR EMBL; AK176679; BAD44442.1; -; mRNA.
DR EMBL; BT024616; ABD43014.1; -; mRNA.
DR EMBL; AY085925; AAM63137.1; -; mRNA.
DR PIR; D86352; D86352.
DR RefSeq; NP_173609.1; NM_102039.3.
DR AlphaFoldDB; Q9SFE4; -.
DR SMR; Q9SFE4; -.
DR BioGRID; 24032; 3.
DR IntAct; Q9SFE4; 3.
DR STRING; 3702.AT1G21910.1; -.
DR PaxDb; Q9SFE4; -.
DR PRIDE; Q9SFE4; -.
DR EnsemblPlants; AT1G21910.1; AT1G21910.1; AT1G21910.
DR GeneID; 838793; -.
DR Gramene; AT1G21910.1; AT1G21910.1; AT1G21910.
DR KEGG; ath:AT1G21910; -.
DR Araport; AT1G21910; -.
DR TAIR; locus:2201103; AT1G21910.
DR eggNOG; ENOG502RMWY; Eukaryota.
DR HOGENOM; CLU_063331_2_0_1; -.
DR InParanoid; Q9SFE4; -.
DR OMA; SSWYDDH; -.
DR OrthoDB; 1414850at2759; -.
DR PhylomeDB; Q9SFE4; -.
DR PRO; PR:Q9SFE4; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SFE4; baseline and differential.
DR Genevisible; Q9SFE4; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0071497; P:cellular response to freezing; IEP:TAIR.
DR GO; GO:0034605; P:cellular response to heat; IEP:TAIR.
DR GO; GO:0009873; P:ethylene-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:TAIR.
DR GO; GO:0009753; P:response to jasmonic acid; IEP:TAIR.
DR GO; GO:0009751; P:response to salicylic acid; IEP:TAIR.
DR CDD; cd00018; AP2; 1.
DR Gene3D; 3.30.730.10; -; 1.
DR InterPro; IPR001471; AP2/ERF_dom.
DR InterPro; IPR036955; AP2/ERF_dom_sf.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR Pfam; PF00847; AP2; 1.
DR PRINTS; PR00367; ETHRSPELEMNT.
DR SMART; SM00380; AP2; 1.
DR SUPFAM; SSF54171; SSF54171; 1.
DR PROSITE; PS51032; AP2_ERF; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Ethylene signaling pathway; Nucleus;
KW Reference proteome; Stress response; Transcription;
KW Transcription regulation.
FT CHAIN 1..230
FT /note="Ethylene-responsive transcription factor ERF012"
FT /id="PRO_0000290374"
FT DNA_BIND 49..106
FT /note="AP2/ERF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00366"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 37
FT /note="S -> SS (in Ref. 5; AAM63137)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 230 AA; 25476 MW; E7F6CF62AEADCBA7 CRC64;
MVKQERKIQT SSTKKEMPLS SSPSSSSSSS SSSSSSSCKN KNKKSKIKKY KGVRMRSWGS
WVSEIRAPNQ KTRIWLGSYS TAEAAARAYD VALLCLKGPQ ANLNFPTSSS SHHLLDNLLD
ENTLLSPKSI QRVAAQAANS FNHFAPTSSA VSSPSDHDHH HDDGMQSLMG SFVDNHVSLM
DSTSSWYDDH NGMFLFDNGA PFNYSPQLNS TTMLDEYFYE DADIPLWSFN
