ID   ERF1_BLEAM              Reviewed;         436 AA.
AC   Q9BMM3;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Eukaryotic peptide chain release factor subunit 1;
DE            Short=Eukaryotic release factor 1;
DE            Short=eRF1;
GN   Name=eRF1;
OS   Blepharisma americanum (Ciliate).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Postciliodesmatophora;
OC   Heterotrichea; Heterotrichida; Blepharismidae; Blepharisma.
OX   NCBI_TaxID=5960;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=CCAP 1607/1;
RX   PubMed=11231122; DOI=10.1016/s0960-9822(01)00028-8;
RA   Lozupone C.A., Knight R.D., Landweber L.F.;
RT   "The molecular basis of nuclear genetic code change in ciliates.";
RL   Curr. Biol. 11:65-74(2001).
CC   -!- FUNCTION: Directs the termination of nascent peptide synthesis
CC       (translation) in response to the termination codons UAA and UAG. In
CC       B.americanum UGA codes for tryptophan.
CC   -!- SUBUNIT: Heterodimer of two subunits, one of which binds GTP.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the eukaryotic release factor 1 family.
CC       {ECO:0000305}.
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DR   EMBL; AF317831; AAK12089.1; -; mRNA.
DR   AlphaFoldDB; Q9BMM3; -.
DR   SMR; Q9BMM3; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003747; F:translation release factor activity; IEA:InterPro.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.30.420.60; -; 1.
DR   Gene3D; 3.30.960.10; -; 1.
DR   InterPro; IPR042226; eFR1_2_sf.
DR   InterPro; IPR005140; eRF1_1_Pelota.
DR   InterPro; IPR024049; eRF1_1_sf.
DR   InterPro; IPR005141; eRF1_2.
DR   InterPro; IPR005142; eRF1_3.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004403; Peptide_chain-rel_eRF1/aRF1.
DR   PANTHER; PTHR10113; PTHR10113; 1.
DR   Pfam; PF03463; eRF1_1; 1.
DR   Pfam; PF03464; eRF1_2; 1.
DR   Pfam; PF03465; eRF1_3; 1.
DR   SMART; SM01194; eRF1_1; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   SUPFAM; SSF55481; SSF55481; 1.
DR   TIGRFAMs; TIGR03676; aRF1/eRF1; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Protein biosynthesis.
FT   CHAIN           1..436
FT                   /note="Eukaryotic peptide chain release factor subunit 1"
FT                   /id="PRO_0000143146"
SQ   SEQUENCE   436 AA;  49564 MW;  EEC2800C24FEA0C7 CRC64;
     MEGDELTQNI EQWKIKRLID NLDKARGNGT SLISLIIPPR EQLPIINKMI TEEYGKSSNI
     KSRIVRQAVQ SALTSTKERL KLYNNRLPAN GLILYCGEVI NEEGVCEKKY TIDFQPYRAI
     NTTLYICDNK FHTQPLKDLL VMDDKFGFII IDGNGTLFGT LQGNTKEVLH KFSVDLPKKH
     RRGGQSALRF ARLRMESRNN YLRKVAEQAV VQFISSDKVN VAGLIIAGSA EFKNVLVQSD
     LFDQRLAAKV LKIVDVAYGG ENGFTQAIEL SADTLSNIKF IREKKVMSKF FEEVAQDTKK
     YCYGVEDTMK SLLMGAVEVI LLFENLNFTR YVLKNPTTGI EKTLYLTPEQ EENHDNFIEN
     GEELEALEKG PLPEWIVDNY MKFGAGLEFI TDRSQEGAQF VRGFGGLGAF LRYQVDMAHL
     NAGEEELDEE WDDDFM