ID   ERF1_DICDI              Reviewed;         441 AA.
AC   Q9BMX0; Q54IP1;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Eukaryotic peptide chain release factor subunit 1;
DE            Short=Eukaryotic release factor 1;
DE            Short=eRF1;
GN   Name=erf1; ORFNames=DDB_G0288613;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11160924; DOI=10.1093/nar/29.4.921;
RA   Inagaki Y., Doolittle W.F.;
RT   "Class I release factors in ciliates with variant genetic codes.";
RL   Nucleic Acids Res. 29:921-927(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Directs the termination of nascent peptide synthesis
CC       (translation) in response to the termination codons UAA, UAG and UGA.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of two subunits, one of which binds GTP.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic release factor 1 family.
CC       {ECO:0000305}.
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DR   EMBL; AF298834; AAK07832.1; -; mRNA.
DR   EMBL; AAFI02000119; EAL63131.1; -; Genomic_DNA.
DR   RefSeq; XP_636638.1; XM_631546.1.
DR   AlphaFoldDB; Q9BMX0; -.
DR   SMR; Q9BMX0; -.
DR   STRING; 44689.DDB0191343; -.
DR   PaxDb; Q9BMX0; -.
DR   PRIDE; Q9BMX0; -.
DR   EnsemblProtists; EAL63131; EAL63131; DDB_G0288613.
DR   GeneID; 8626719; -.
DR   KEGG; ddi:DDB_G0288613; -.
DR   dictyBase; DDB_G0288613; erf1.
DR   eggNOG; KOG0688; Eukaryota.
DR   HOGENOM; CLU_035759_2_1_1; -.
DR   InParanoid; Q9BMX0; -.
DR   OMA; GQEMEVV; -.
DR   PhylomeDB; Q9BMX0; -.
DR   Reactome; R-DDI-72764; Eukaryotic Translation Termination.
DR   Reactome; R-DDI-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-DDI-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   PRO; PR:Q9BMX0; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0018444; C:translation release factor complex; IBA:GO_Central.
DR   GO; GO:1990825; F:sequence-specific mRNA binding; IBA:GO_Central.
DR   GO; GO:0016149; F:translation release factor activity, codon specific; IBA:GO_Central.
DR   GO; GO:0002184; P:cytoplasmic translational termination; IBA:GO_Central.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.30.420.60; -; 1.
DR   Gene3D; 3.30.960.10; -; 1.
DR   InterPro; IPR042226; eFR1_2_sf.
DR   InterPro; IPR005140; eRF1_1_Pelota.
DR   InterPro; IPR024049; eRF1_1_sf.
DR   InterPro; IPR005141; eRF1_2.
DR   InterPro; IPR005142; eRF1_3.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004403; Peptide_chain-rel_eRF1/aRF1.
DR   PANTHER; PTHR10113; PTHR10113; 1.
DR   Pfam; PF03463; eRF1_1; 1.
DR   Pfam; PF03464; eRF1_2; 1.
DR   Pfam; PF03465; eRF1_3; 1.
DR   SMART; SM01194; eRF1_1; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   SUPFAM; SSF55481; SSF55481; 1.
DR   TIGRFAMs; TIGR03676; aRF1/eRF1; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..441
FT                   /note="Eukaryotic peptide chain release factor subunit 1"
FT                   /id="PRO_0000143150"
FT   CONFLICT        334
FT                   /note="L -> F (in Ref. 1; AAK07832)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   441 AA;  49346 MW;  A790AA1F6D2AF974 CRC64;
     MSAVDDQQNA DKQVEQWKIK KLIKNLEAAR GNGTSMISLI IRPGDQIAKV NKMLAEEYGT
     ASNIKSRVNR LSVLGAITSA QQRLKLYTKV PDNGLVIYCG TMVTDEGKEK PVRIDIEPFK
     PINTSLYLCD NKFHTAPLGE LLESDEKFGF IVVDGNGALF GLLCGSTRTV LHKITVDLPK
     KHGRGGQSAL RFARLRMEKR HNYVRKVSEL ATQFYVTNDK PNVSGLILAG SADFKTELGT
     SDMFDQRLRE KIIKIVDVSY GGDNGFNQAI ELSGEVLSSV KFIQEKKLIS QFFEEIAQDT
     GKYCFGIADT LKALDLGAAH TLIVWESLET IRYLLRLPTG EEKVIFLNKD QNKDASVFKD
     KESGLDYEIV EEMPIVEWFA NNYKNFGASL EFVTNKSQEG SQFCKGFGGL GGLLRYQVDF
     AQLNDFDNPD ENEYDDSDSD F