ID   ERF1_GIAIN              Reviewed;         457 AA.
AC   Q9NCP1;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Eukaryotic peptide chain release factor subunit 1;
DE            Short=Eukaryotic release factor 1;
DE            Short=eRF1;
GN   Name=ERF1;
OS   Giardia intestinalis (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=5741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10833194; DOI=10.1093/oxfordjournals.molbev.a026368;
RA   Inagaki Y., Doolittle W.F.;
RT   "Evolution of the eukaryotic translation termination system: origins of
RT   release factors.";
RL   Mol. Biol. Evol. 17:882-889(2000).
CC   -!- FUNCTION: Directs the termination of nascent peptide synthesis
CC       (translation) in response to the termination codons UAA, UAG and UGA.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of two subunits, one of which binds GTP.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic release factor 1 family.
CC       {ECO:0000305}.
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DR   EMBL; AF198107; AAF74402.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9NCP1; -.
DR   SMR; Q9NCP1; -.
DR   PRIDE; Q9NCP1; -.
DR   VEuPathDB; GiardiaDB:DHA2_17190; -.
DR   VEuPathDB; GiardiaDB:GL50581_4071; -.
DR   VEuPathDB; GiardiaDB:GL50803_0017190; -.
DR   eggNOG; KOG0688; Eukaryota.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003747; F:translation release factor activity; IEA:InterPro.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.30.420.60; -; 1.
DR   Gene3D; 3.30.960.10; -; 1.
DR   InterPro; IPR042226; eFR1_2_sf.
DR   InterPro; IPR005140; eRF1_1_Pelota.
DR   InterPro; IPR024049; eRF1_1_sf.
DR   InterPro; IPR005141; eRF1_2.
DR   InterPro; IPR005142; eRF1_3.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004403; Peptide_chain-rel_eRF1/aRF1.
DR   PANTHER; PTHR10113; PTHR10113; 1.
DR   Pfam; PF03463; eRF1_1; 1.
DR   Pfam; PF03464; eRF1_2; 1.
DR   Pfam; PF03465; eRF1_3; 1.
DR   SMART; SM01194; eRF1_1; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   SUPFAM; SSF55481; SSF55481; 1.
DR   TIGRFAMs; TIGR03676; aRF1/eRF1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Protein biosynthesis.
FT   CHAIN           1..457
FT                   /note="Eukaryotic peptide chain release factor subunit 1"
FT                   /id="PRO_0000143154"
SQ   SEQUENCE   457 AA;  51029 MW;  EE185FFFD1F0C943 CRC64;
     MSINPDAPQS NGEQERQIAI WQLKRTIEKL ESYTGSGTSV ISLLIPPGEQ LSSVTGMLTN
     EYGTASNIKS RVNKNAVLSA ITSAMSRLKL YNRLPPNGLA VYCGEIEEDG KNTKVVIDYT
     PYKPISNFIY LCDSKFHTEH LRELLTNDDT FGFIIMDGKE TLMATLSGTV RTILDRSTVD
     LPKKHGRGGQ SSVRFARLRE EARHNYVRKV AERANSLFIS SGPTGTNKPI VSGLILGGSA
     DFKNVLSTSA IFDQRLQSIV MKQIDINYGG EQGFNQAIEM AGDTLKDVKL IQEVKLLTEF
     TENIAKDTKR VCFGITDTIR CLEMSAVEKL IVWDDLPYHR VTLQCVINGE TSAPVIKYLL
     KSQMSNPKYL REVINGEEVQ LDIMGDQLLL EWFVDNYKNY GASLEFITNR SAEGTQFCSG
     FGGIGGLLRW QVDLVEAARF MQESDEDSFM DDLEDFI