ID   ERF1_STYLE              Reviewed;         445 AA.
AC   Q9BMM0;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Eukaryotic peptide chain release factor subunit 1;
DE            Short=Eukaryotic release factor 1;
DE            Short=eRF1;
GN   Name=ERF1;
OS   Stylonychia lemnae (Ciliate).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC   Stichotrichia; Sporadotrichida; Oxytrichidae; Stylonychinae; Stylonychia.
OX   NCBI_TaxID=5949;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11231122; DOI=10.1016/s0960-9822(01)00028-8;
RA   Lozupone C.A., Knight R.D., Landweber L.F.;
RT   "The molecular basis of nuclear genetic code change in ciliates.";
RL   Curr. Biol. 11:65-74(2001).
CC   -!- FUNCTION: Directs the termination of nascent peptide synthesis
CC       (translation) in response to the termination codon UGA. In Stylonchia
CC       UAA and UAG codes for glutamine.
CC   -!- SUBUNIT: Heterodimer of two subunits, one of which binds GTP.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the eukaryotic release factor 1 family.
CC       {ECO:0000305}.
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DR   EMBL; AF317834; AAK12092.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9BMM0; -.
DR   SMR; Q9BMM0; -.
DR   OMA; GQEMEVV; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003747; F:translation release factor activity; IEA:InterPro.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.30.420.60; -; 1.
DR   Gene3D; 3.30.960.10; -; 1.
DR   InterPro; IPR042226; eFR1_2_sf.
DR   InterPro; IPR005140; eRF1_1_Pelota.
DR   InterPro; IPR024049; eRF1_1_sf.
DR   InterPro; IPR005141; eRF1_2.
DR   InterPro; IPR005142; eRF1_3.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004403; Peptide_chain-rel_eRF1/aRF1.
DR   PANTHER; PTHR10113; PTHR10113; 1.
DR   Pfam; PF03463; eRF1_1; 1.
DR   Pfam; PF03464; eRF1_2; 1.
DR   Pfam; PF03465; eRF1_3; 1.
DR   SMART; SM01194; eRF1_1; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   SUPFAM; SSF55481; SSF55481; 1.
DR   TIGRFAMs; TIGR03676; aRF1/eRF1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Protein biosynthesis.
FT   CHAIN           1..445
FT                   /note="Eukaryotic peptide chain release factor subunit 1"
FT                   /id="PRO_0000143158"
SQ   SEQUENCE   445 AA;  49559 MW;  CCE0D191E15D74EC CRC64;
     MVESIAAGQV GDNKHIEMWK IKRLINKLEN CKGNGTSMVS LIIPPKEDIN KSGKLLVGEL
     SAAQNIKSRI TRQSVITAIT STKEKLKLYR QTPTNGLCIY CGVILMEDGK TEKKINFDFE
     PFRPINQFMY FCGGKFQTEP LTTLLADDDK FGFIIVDGNG ALYATLQGNS REILQKITVE
     LPKKHRKGGQ SSVRFARLRE EKRHNYLRKV AELAGSNFIT NDKPNVTGLV LAGNAGFKNE
     LSETDMLDKR LLPIIVSIVD VSYGGENGLN EAITLSADAL TNVKFVAEKK LVSTFFEQIS
     LDTGMIVFGV QDTMKALELG AVETILLFEE LEITRYVIKN PVKGDTRTLF LNPTQQKDSK
     YFKDQASGLD MDVIAEDQLA EWLCHNYQNY GAQVEFITDK SQEGYQFVKG FGGIGGFLRY
     KVDMEDALGD VGDGGDDFDP DTDFI