ERF1_TOBAC
ID ERF1_TOBAC Reviewed; 236 AA.
AC Q40476;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Ethylene-responsive transcription factor 1;
DE Short=NtERF1;
DE AltName: Full=Ethylene-responsive element-binding factor 1;
DE Short=EREBP-1;
GN Name=ERF1; Synonyms=ERF-1;
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Bright Yellow 4; TISSUE=Leaf;
RX PubMed=7756828; DOI=10.2307/3869993;
RA Ohme-Takagi M., Shinshi H.;
RT "Ethylene-inducible DNA binding proteins that interact with an ethylene
RT responsive element.";
RL Plant Cell 7:173-182(1995).
RN [2]
RP FUNCTION, AND INDUCTION.
RX DOI=10.1046/j.1365-313x.1998.00243.x;
RA Suzuki K., Suzuki N., Ohme-Takagi M., Shinshi H.;
RT "Immediate early induction of mRNAs for ethylene-responsive transcription
RT factors in tobacco leaf strips after cutting.";
RL Plant J. 15:657-665(1998).
RN [3]
RP INDUCTION.
RX PubMed=9725022; DOI=10.1094/mpmi.1998.11.9.895;
RA Horvath D.M., Huang D.J., Chua N.-H.;
RT "Four classes of salicylate-induced tobacco genes.";
RL Mol. Plant Microbe Interact. 11:895-905(1998).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=11440157; DOI=10.1271/bbb.65.1270;
RA Koyama T., Kitajima S., Sato F.;
RT "Expression of PR-5d and ERF genes in cultured tobacco cells and their NaCl
RT stress-response.";
RL Biosci. Biotechnol. Biochem. 65:1270-1273(2001).
CC -!- FUNCTION: Probably acts as a transcriptional activator and may be
CC involved in disease resistance pathways (By similarity). Binds to the
CC GCC-box pathogenesis-related promoter element. Involved in the
CC regulation of gene expression by stress factors and by components of
CC stress signal transduction pathways mediated by ethylene, that seems to
CC depend on a protein kinase cascade and to be influenced by methyl-
CC jasmonate. {ECO:0000250, ECO:0000269|PubMed:7756828,
CC ECO:0000269|Ref.2}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in roots and at low levels in buds and
CC leaves. Highly expressed in cell culture, especially during the
CC exponential phase. {ECO:0000269|PubMed:11440157,
CC ECO:0000269|PubMed:7756828}.
CC -!- INDUCTION: Highly and transiently expressed in tobacco mosaic virus
CC (TMV) infected leaves. Induced by methyl-jasmonate (MeJA), and by
CC ethephon (ethylene-releasing compound) in buds and to lower extent in
CC leaves. Quickly and transiently induced by salicylic acid (SA).
CC Strongly induced by wounding, independently of ethylene, and through a
CC de-novo-protein-synthesis-independent regulation. Wound induction is
CC reduced by MeJA. Also induced by acetyl salicylic acid (ASA),
CC cycloheximide, auxin (2,4-D), and benzoic acid (BA) but seems to not be
CC influenced by 4-hydroxybenzoic acid (4HBA), thiamine, H(2)O(2) or
CC abscisic acid (ABA). {ECO:0000269|PubMed:7756828,
CC ECO:0000269|PubMed:9725022, ECO:0000269|Ref.2}.
CC -!- DOMAIN: The AP2/ERF domain binds specifically to the 5'-GCCGCC-3'
CC motif. The affinity of this binding is higher if the seventh amino-acid
CC of this domain is basic (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ethylene-response factor family. Class 1
CC subfamily. {ECO:0000305}.
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DR EMBL; D38123; BAA07321.1; -; mRNA.
DR PIR; T02432; T02432.
DR RefSeq; NP_001313071.1; NM_001326142.1.
DR AlphaFoldDB; Q40476; -.
DR STRING; 4097.Q40476; -.
DR GeneID; 107825044; -.
DR KEGG; nta:107825044; -.
DR OMA; FPVYRRN; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0009873; P:ethylene-activated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00018; AP2; 1.
DR Gene3D; 3.30.730.10; -; 1.
DR InterPro; IPR001471; AP2/ERF_dom.
DR InterPro; IPR036955; AP2/ERF_dom_sf.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR044808; ERF_plant.
DR PANTHER; PTHR31190; PTHR31190; 1.
DR Pfam; PF00847; AP2; 1.
DR PRINTS; PR00367; ETHRSPELEMNT.
DR SMART; SM00380; AP2; 1.
DR SUPFAM; SSF54171; SSF54171; 1.
DR PROSITE; PS51032; AP2_ERF; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Ethylene signaling pathway; Nucleus; Plant defense;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..236
FT /note="Ethylene-responsive transcription factor 1"
FT /id="PRO_0000112545"
FT DNA_BIND 104..162
FT /note="AP2/ERF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00366"
FT REGION 163..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 236 AA; 26520 MW; 6B030DEB9BFDE2D5 CRC64;
MNQPIYTELP PANFPGEFPV YRRNSSFSRL IPCLTETWGD LPLKVDDSED MVIYTLLKDA
LNVGWSPFNF SAGEVKSEQR EEEIVVSPAE TTAAPAAELP RGRHYRGVRR RPWGKFAAEI
RDPAKNGARV WLGTYETDEE AAIAYDKAAY RMRGSKAHLN FPHRIGLNEP EPVRVTAKRR
ASPEPASSSE NSSPKRRRKA VATEKSEAVE VESKSNVLQT GCQVELLTRR HQLLVS
