ID   ERF1_TRYBB              Reviewed;         452 AA.
AC   Q9NAX8;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Eukaryotic peptide chain release factor subunit 1;
DE            Short=Eukaryotic release factor 1;
DE            Short=eRF1;
GN   Name=ERF1;
OS   Trypanosoma brucei brucei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Jean-Jean O., Kervestin S., Salhi S.;
RT   "Eukaryotic release factor 1 from Trypanosoma brucei.";
RL   Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Directs the termination of nascent peptide synthesis
CC       (translation) in response to the termination codons UAA, UAG and UGA.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of two subunits, one of which binds GTP.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic release factor 1 family.
CC       {ECO:0000305}.
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DR   EMBL; AF278718; AAF86346.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9NAX8; -.
DR   SMR; Q9NAX8; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003729; F:mRNA binding; IDA:GeneDB.
DR   GO; GO:0003747; F:translation release factor activity; IEA:InterPro.
DR   GO; GO:0010608; P:post-transcriptional regulation of gene expression; IDA:GeneDB.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.30.420.60; -; 1.
DR   Gene3D; 3.30.960.10; -; 1.
DR   InterPro; IPR042226; eFR1_2_sf.
DR   InterPro; IPR005140; eRF1_1_Pelota.
DR   InterPro; IPR024049; eRF1_1_sf.
DR   InterPro; IPR005141; eRF1_2.
DR   InterPro; IPR005142; eRF1_3.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004403; Peptide_chain-rel_eRF1/aRF1.
DR   PANTHER; PTHR10113; PTHR10113; 1.
DR   Pfam; PF03463; eRF1_1; 1.
DR   Pfam; PF03464; eRF1_2; 1.
DR   Pfam; PF03465; eRF1_3; 1.
DR   SMART; SM01194; eRF1_1; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   SUPFAM; SSF55481; SSF55481; 1.
DR   TIGRFAMs; TIGR03676; aRF1/eRF1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Protein biosynthesis.
FT   CHAIN           1..452
FT                   /note="Eukaryotic peptide chain release factor subunit 1"
FT                   /id="PRO_0000143161"
SQ   SEQUENCE   452 AA;  51007 MW;  B9A3BB75B7960E9E CRC64;
     MTDHELSESE KAIERYKVKK LIQMLESARG MGTSVISIYM TPKEQISGMV TKLNNEYGTA
     SNIKSHTNKL SVQSAITASL GRLKQYNRLP PNGLLLYCGT VLTAENKEKK LTLDIEPFKP
     VSRSLYLCDN KFHTEELHRM LESDEKFGFI VVDGSGTTYA TLCGSVKEKL SSFTVELPKK
     HGRGGQSKNR FARIRMERRH NYLRKVAEGA TQLFITNDRP NIVGLVLAGS AEFKEVLYQS
     DLFDPRLKAI VVKVVDVAHP GDVGLNQAID LAADALSGVK LVQEKKLLQG FFDQIACDTQ
     LYCFGVQDTL KCLEAGAVET LIVYEDLNIY RYTVVKNRGA DDEETFVHVM SEEEAKRSNI
     HMQESGKTRN EIEQEDFVDW LATNYRKFGC ALELITNRSQ EGTQFVRGFG GIGGVLRYKL
     DIIALRDVEK KEDDEERIAA NNEEFDFDDD FM