ERF2_NICSY
ID ERF2_NICSY Reviewed; 237 AA.
AC Q9LW50;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Ethylene-responsive transcription factor 2;
DE Short=NsERF2;
DE AltName: Full=Ethylene-responsive element-binding factor 2;
DE Short=EREBP-2;
GN Name=ERF2; Synonyms=ERF-2;
OS Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4096;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION, AND TISSUE SPECIFICITY.
RX PubMed=10945353; DOI=10.1093/pcp/41.6.817;
RA Kitajima S., Koyama T., Ohme-Takagi M., Shinshi H., Sato F.;
RT "Characterization of gene expression of NsERFs, transcription factors of
RT basic PR genes from Nicotiana sylvestris.";
RL Plant Cell Physiol. 41:817-824(2000).
CC -!- FUNCTION: Transcription factor that binds to the GCC-box pathogenesis-
CC related promoter element. Involved in the regulation of gene expression
CC by stress factors and by components of stress signal transduction
CC pathways. Probably acts as a transcriptional activator (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Weakly expressed in roots.
CC {ECO:0000269|PubMed:10945353}.
CC -!- INDUCTION: Induced by ethylene. {ECO:0000269|PubMed:10945353}.
CC -!- DOMAIN: The AP2/ERF domain binds specifically to the 5'-GCCGCC-3'
CC motif. The affinity of this binding is higher if the seventh amino-acid
CC of this domain is basic (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ethylene-response factor family. Class 1
CC subfamily. {ECO:0000305}.
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DR EMBL; AB016264; BAA97122.1; -; Genomic_DNA.
DR RefSeq; XP_009765938.1; XM_009767636.1.
DR AlphaFoldDB; Q9LW50; -.
DR STRING; 4096.XP_009765938.1; -.
DR GeneID; 104217398; -.
DR KEGG; nsy:104217398; -.
DR eggNOG; ENOG502QRIC; Eukaryota.
DR Proteomes; UP000189701; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0009873; P:ethylene-activated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00018; AP2; 1.
DR Gene3D; 3.30.730.10; -; 1.
DR InterPro; IPR001471; AP2/ERF_dom.
DR InterPro; IPR036955; AP2/ERF_dom_sf.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR044808; ERF_plant.
DR PANTHER; PTHR31190; PTHR31190; 1.
DR Pfam; PF00847; AP2; 1.
DR PRINTS; PR00367; ETHRSPELEMNT.
DR SMART; SM00380; AP2; 1.
DR SUPFAM; SSF54171; SSF54171; 1.
DR PROSITE; PS51032; AP2_ERF; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Ethylene signaling pathway; Nucleus; Plant defense;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..237
FT /note="Ethylene-responsive transcription factor 2"
FT /id="PRO_0000112547"
FT DNA_BIND 102..160
FT /note="AP2/ERF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00366"
FT REGION 175..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 237 AA; 26243 MW; 01BC3EEB51E46298 CRC64;
MYQPISTEFP VYHRTSSFSS LMPCLTDTWG DLPLKVDDSE DMVIYGLLSD ALTTGWTPFN
LTSTEIKAEP REEIEPATSP VPSVAPPAET TTAQAVVPKG RHYRGVRQRP WGKFAAEIRD
PAKNGARVWL GTYETAEEAA LAYDKAAYRM RGSKALLNFP HRIGLNEPEP VRLTVKRRSP
EPASSSISPA SENSLPKRRR KAVAAKQAEL EVQSRSNVMQ VGCQMEQFPV GEQLLVS
