ID   ERF5_NICSY              Reviewed;         282 AA.
AC   Q9LW48;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Ethylene-responsive transcription factor 5;
DE   AltName: Full=Ethylene-responsive element-binding factor 4;
DE            Short=EREBP-4;
DE   AltName: Full=Ethylene-responsive element-binding factor 5 homolog;
DE   AltName: Full=NsERF4;
GN   Name=ERF5; Synonyms=ERF-4, ERF4;
OS   Nicotiana sylvestris (Wood tobacco) (South American tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4096;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION, AND TISSUE SPECIFICITY.
RX   PubMed=10945353; DOI=10.1093/pcp/41.6.817;
RA   Kitajima S., Koyama T., Ohme-Takagi M., Shinshi H., Sato F.;
RT   "Characterization of gene expression of NsERFs, transcription factors of
RT   basic PR genes from Nicotiana sylvestris.";
RL   Plant Cell Physiol. 41:817-824(2000).
CC   -!- FUNCTION: Transcription factor that binds to the GCC-box pathogenesis-
CC       related promoter element. Involved in the regulation of gene expression
CC       by stress factors and by components of stress signal transduction
CC       pathways. Probably acts as a transcriptional activator (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots, mostly in root tip and lateral
CC       root tips. {ECO:0000269|PubMed:10945353}.
CC   -!- INDUCTION: Induced by ethylene. {ECO:0000269|PubMed:10945353}.
CC   -!- DOMAIN: The AP2/ERF domain binds specifically to the 5'-GCCGCC-3'
CC       motif. The affinity of this binding is higher if the seventh amino-acid
CC       of this domain is basic (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ethylene-response factor family. Class 3
CC       subfamily. {ECO:0000305}.
CC   -!- CAUTION: Was named ERF4 but it corresponds to Arabidopsis ERF5.
CC       {ECO:0000305}.
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DR   EMBL; AB016266; BAA97124.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9LW48; -.
DR   SMR; Q9LW48; -.
DR   STRING; 4096.XP_009804351.1; -.
DR   PRIDE; Q9LW48; -.
DR   eggNOG; ENOG502RXE3; Eukaryota.
DR   Proteomes; UP000189701; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0009873; P:ethylene-activated signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd00018; AP2; 1.
DR   Gene3D; 3.30.730.10; -; 1.
DR   InterPro; IPR001471; AP2/ERF_dom.
DR   InterPro; IPR036955; AP2/ERF_dom_sf.
DR   InterPro; IPR016177; DNA-bd_dom_sf.
DR   Pfam; PF00847; AP2; 1.
DR   PRINTS; PR00367; ETHRSPELEMNT.
DR   SMART; SM00380; AP2; 1.
DR   SUPFAM; SSF54171; SSF54171; 1.
DR   PROSITE; PS51032; AP2_ERF; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Ethylene signaling pathway; Nucleus; Plant defense;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..282
FT                   /note="Ethylene-responsive transcription factor 5"
FT                   /id="PRO_0000112564"
FT   DNA_BIND        137..195
FT                   /note="AP2/ERF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00366"
SQ   SEQUENCE   282 AA;  31832 MW;  8C6C62E72660D1C9 CRC64;
     MASPQENSTT LDLIRQHLLD DNVFLEHYCS ETETTTLIYS QSSSSSESLD QSFSFEPTLN
     YATTAQSSNL EVSTFFNNSK TEFDSFEFGT IPNVSAARSS SLKQTSFKER KPSLNIAIPV
     KQEVVQKVEL APTEKKHYRG VRQRPWGKFA AEIRDPNRKG TRVWLGTFDT AIEAAKAYDR
     AAYKLRGSKA IVNFPLEVAN FKQEFNNEIR PLVNSSRKRV RETVNEEQLV INKEMKIEEE
     RVPTAPLTPS SWSAIWDSGD GKGIFEVPPL SPFGAYSQLV MI