ERF71_ARATH
ID ERF71_ARATH Reviewed; 171 AA.
AC O22259;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Ethylene-responsive transcription factor ERF071 {ECO:0000305};
DE Short=AtERF71 {ECO:0000303|PubMed:25344007};
DE AltName: Full=Protein HYPOXIA RESPONSIVE ERF 2 {ECO:0000303|PubMed:20113439};
GN Name=ERF071 {ECO:0000303|PubMed:16407444};
GN Synonyms=ERF71 {ECO:0000303|PubMed:21615413},
GN HRE2 {ECO:0000303|PubMed:20113439};
GN OrderedLocusNames=At2g47520 {ECO:0000312|Araport:AT2G47520};
GN ORFNames=T30B22.18 {ECO:0000312|EMBL:AAC62858.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16407444; DOI=10.1104/pp.105.073783;
RA Nakano T., Suzuki K., Fujimura T., Shinshi H.;
RT "Genome-wide analysis of the ERF gene family in Arabidopsis and rice.";
RL Plant Physiol. 140:411-432(2006).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION BY HYPOXIA.
RX PubMed=20113439; DOI=10.1111/j.1365-313x.2010.04149.x;
RA Licausi F., van Dongen J.T., Giuntoli B., Novi G., Santaniello A.,
RA Geigenberger P., Perata P.;
RT "HRE1 and HRE2, two hypoxia-inducible ethylene response factors, affect
RT anaerobic responses in Arabidopsis thaliana.";
RL Plant J. 62:302-315(2010).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION.
RX PubMed=21946064; DOI=10.1016/j.bbrc.2011.09.039;
RA Park H.Y., Seok H.Y., Woo D.H., Lee S.Y., Tarte V.N., Lee E.H., Lee C.H.,
RA Moon Y.H.;
RT "AtERF71/HRE2 transcription factor mediates osmotic stress response as well
RT as hypoxia response in Arabidopsis.";
RL Biochem. Biophys. Res. Commun. 414:135-141(2011).
RN [7]
RP FUNCTION, AND OXIDATION AT CYS-2.
RX PubMed=22020279; DOI=10.1038/nature10534;
RA Gibbs D.J., Lee S.C., Isa N.M., Gramuglia S., Fukao T., Bassel G.W.,
RA Correia C.S., Corbineau F., Theodoulou F.L., Bailey-Serres J.,
RA Holdsworth M.J.;
RT "Homeostatic response to hypoxia is regulated by the N-end rule pathway in
RT plants.";
RL Nature 479:415-418(2011).
RN [8]
RP FUNCTION, AND INDUCTION BY HYPOXIA.
RX PubMed=21615413; DOI=10.1111/j.1399-3054.2011.01486.x;
RA Hess N., Klode M., Anders M., Sauter M.;
RT "The hypoxia responsive transcription factor genes ERF71/HRE2 and
RT ERF73/HRE1 of Arabidopsis are differentially regulated by ethylene.";
RL Physiol. Plantarum 143:41-49(2011).
RN [9]
RP FUNCTION.
RX PubMed=25344007; DOI=10.1007/s00299-014-1701-9;
RA Lee S.Y., Hwang E.Y., Seok H.Y., Tarte V.N., Jeong M.S., Jang S.B.,
RA Moon Y.H.;
RT "Arabidopsis AtERF71/HRE2 functions as transcriptional activator via cis-
RT acting GCC box or DRE/CRT element and is involved in root development
RT through regulation of root cell expansion.";
RL Plant Cell Rep. 34:223-231(2015).
RN [10]
RP FUNCTION, AND INDUCTION BY HYPOXIA.
RX PubMed=28698356; DOI=10.1104/pp.17.00555;
RA Eysholdt-Derzso E., Sauter M.;
RT "Root bending is antagonistically affected by hypoxia and ERF-mediated
RT transcription via auxin signaling.";
RL Plant Physiol. 175:412-423(2017).
RN [11]
RP FUNCTION, AND INDUCTION BY FUSARIUM GRAMINEARUM.
RX PubMed=31819723; DOI=10.5511/plantbiotechnology.18.0501b;
RA Yelli F., Kato T., Nishiuchi T.;
RT "The possible roles of AtERF71 in the defense response against the Fusarium
RT graminearum.";
RL Plant Biotechnol. 35:187-192(2018).
RN [12]
RP FUNCTION, AND INDUCTION BY HYPOXIA.
RX PubMed=30535180; DOI=10.1093/aob/mcy202;
RA Wany A., Gupta A.K., Kumari A., Mishra S., Singh N., Pandey S., Vanvari R.,
RA Igamberdiev A.U., Fernie A.R., Gupta K.J.;
RT "Nitrate nutrition influences multiple factors in order to increase energy
RT efficiency under hypoxia in Arabidopsis.";
RL Ann. Bot. 123:691-705(2019).
RN [13]
RP FUNCTION.
RX PubMed=29996004; DOI=10.1111/plb.12873;
RA Eysholdt-Derzso E., Sauter M.;
RT "Hypoxia and the group VII ethylene response transcription factor HRE2
RT promote adventitious root elongation in Arabidopsis.";
RL Plant Biol. 21:103-108(2019).
CC -!- FUNCTION: Transcriptional activator that binds specifically to the cis-
CC acting element GCC box 5'-AGCCGCC-3', or to the CRT/DRE element 5'-
CC [AG]CCGAC-3' (PubMed:25344007). Plays an important role in root
CC development via root cell expansion regulation (PubMed:25344007).
CC Transcriptional activator involved in the hypoxic stress response
CC (PubMed:20113439, PubMed:21615413, PubMed:21946064). Plays a role in
CC low oxygen signaling and contributes to tolerance to anoxia stress by
CC enhancing anaerobic gene expression and ethanolic fermentation
CC (PubMed:20113439, PubMed:22020279). Plays a role in the regulation of
CC hypoxia-induced root slanting (PubMed:28698356). Contributes to the
CC promotion of adventitious root elongation under hypoxia, an adaptation
CC response that strengthens the root system in upper soil layers where
CC oxygen shortage may last for shorter time periods (PubMed:29996004).
CC Transcriptional activator involved in the osmotic stress response
CC (PubMed:21946064). May play a role in defense response against the
CC fungal pathogen Fusarium graminearum downstream of ethylene signaling
CC (PubMed:31819723). {ECO:0000269|PubMed:20113439,
CC ECO:0000269|PubMed:21615413, ECO:0000269|PubMed:21946064,
CC ECO:0000269|PubMed:22020279, ECO:0000269|PubMed:25344007,
CC ECO:0000269|PubMed:28698356, ECO:0000269|PubMed:29996004,
CC ECO:0000269|PubMed:31819723}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00366,
CC ECO:0000269|PubMed:20113439, ECO:0000269|PubMed:21946064}.
CC -!- INDUCTION: Induced under hypoxic conditions in roots (PubMed:20113439,
CC PubMed:21946064, PubMed:21615413, PubMed:28698356). Induced during
CC hypoxia under nitrate nutrition (PubMed:30535180). Induced by osmotic
CC stress (PubMed:21946064). Induced by infection with the fungal pathogen
CC Fusarium graminearum (PubMed:31819723). {ECO:0000269|PubMed:20113439,
CC ECO:0000269|PubMed:21615413, ECO:0000269|PubMed:21946064,
CC ECO:0000269|PubMed:28698356, ECO:0000269|PubMed:30535180,
CC ECO:0000269|PubMed:31819723}.
CC -!- PTM: In presence of oxygen, the N-terminal cysteine residue (Cys-2) of
CC ERF71 can be oxidized by cysteine oxidases, thus preparing the protein
CC for N-end rule pathway-mediated proteasomal degradation (Probable).
CC Under low oxygen levels, Cys oxidation is prevented, ERF71 is
CC stabilized and confers tolerance to hypoxia (Probable).
CC {ECO:0000305|PubMed:22020279}.
CC -!- SIMILARITY: Belongs to the AP2/ERF transcription factor family. ERF
CC subfamily. {ECO:0000305}.
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DR EMBL; AC002535; AAC62858.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10854.1; -; Genomic_DNA.
DR EMBL; AY074645; AAL69461.1; -; mRNA.
DR PIR; T00432; T00432.
DR RefSeq; NP_182274.1; NM_130320.4.
DR AlphaFoldDB; O22259; -.
DR SMR; O22259; -.
DR ELM; O22259; -.
DR STRING; 3702.AT2G47520.1; -.
DR PaxDb; O22259; -.
DR PRIDE; O22259; -.
DR ProteomicsDB; 220565; -.
DR EnsemblPlants; AT2G47520.1; AT2G47520.1; AT2G47520.
DR GeneID; 819365; -.
DR Gramene; AT2G47520.1; AT2G47520.1; AT2G47520.
DR KEGG; ath:AT2G47520; -.
DR Araport; AT2G47520; -.
DR TAIR; locus:2061956; AT2G47520.
DR eggNOG; ENOG502QW91; Eukaryota.
DR HOGENOM; CLU_054468_2_0_1; -.
DR InParanoid; O22259; -.
DR OMA; IISDFIW; -.
DR OrthoDB; 1505709at2759; -.
DR PhylomeDB; O22259; -.
DR PRO; PR:O22259; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O22259; baseline and differential.
DR Genevisible; O22259; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:UniProtKB.
DR GO; GO:0071456; P:cellular response to hypoxia; HEP:TAIR.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0009873; P:ethylene-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:2000280; P:regulation of root development; IMP:TAIR.
DR GO; GO:0034059; P:response to anoxia; IGI:TAIR.
DR GO; GO:0009414; P:response to water deprivation; IDA:UniProtKB.
DR CDD; cd00018; AP2; 1.
DR Gene3D; 3.30.730.10; -; 1.
DR InterPro; IPR001471; AP2/ERF_dom.
DR InterPro; IPR036955; AP2/ERF_dom_sf.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR044808; ERF_plant.
DR PANTHER; PTHR31190; PTHR31190; 1.
DR Pfam; PF00847; AP2; 1.
DR PRINTS; PR00367; ETHRSPELEMNT.
DR SMART; SM00380; AP2; 1.
DR SUPFAM; SSF54171; SSF54171; 1.
DR PROSITE; PS51032; AP2_ERF; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Ethylene signaling pathway; Nucleus; Oxidation;
KW Plant defense; Reference proteome; Stress response; Transcription;
KW Transcription regulation.
FT CHAIN 1..171
FT /note="Ethylene-responsive transcription factor ERF071"
FT /id="PRO_0000290406"
FT DNA_BIND 49..106
FT /note="AP2/ERF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00366"
FT REGION 16..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="Cysteine sulfinic acid (-SO2H)"
FT /evidence="ECO:0000305|PubMed:22020279"
SQ SEQUENCE 171 AA; 19347 MW; 6F6B221790C39F72 CRC64;
MCGGAIISDF IWSKSESEPS QLGSVSSRKK RKPVSVSEER DGKRERKNLY RGIRQRPWGK
WAAEIRDPSK GVRVWLGTFK TADEAARAYD VAAIKIRGRK AKLNFPNTQV EEEADTKPGG
NQNELISENQ VESLSEDLMA LEDYMRFYQI PVADDQSATD IGNLWSYQDS N
