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ERF73_ARATH
ID   ERF73_ARATH             Reviewed;         262 AA.
AC   Q8H0T5; F4IDA7; Q9C9D5;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-JUN-2021, sequence version 2.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Ethylene-responsive transcription factor ERF073 {ECO:0000305};
DE            Short=AtERF73 {ECO:0000303|PubMed:21398256};
DE   AltName: Full=Protein HYPOXIA RESPONSIVE ERF 1 {ECO:0000303|PubMed:20113439};
GN   Name=ERF073 {ECO:0000303|PubMed:16407444};
GN   Synonyms=ERF73 {ECO:0000303|PubMed:21615413},
GN   HRE1 {ECO:0000303|PubMed:20113439};
GN   OrderedLocusNames=At1g72360 {ECO:0000312|Araport:AT1G72360};
GN   ORFNames=T10D10.17 {ECO:0000312|EMBL:AAG52589.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=16407444; DOI=10.1104/pp.105.073783;
RA   Nakano T., Suzuki K., Fujimura T., Shinshi H.;
RT   "Genome-wide analysis of the ERF gene family in Arabidopsis and rice.";
RL   Plant Physiol. 140:411-432(2006).
RN   [5]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION BY HYPOXIA.
RX   PubMed=20113439; DOI=10.1111/j.1365-313x.2010.04149.x;
RA   Licausi F., van Dongen J.T., Giuntoli B., Novi G., Santaniello A.,
RA   Geigenberger P., Perata P.;
RT   "HRE1 and HRE2, two hypoxia-inducible ethylene response factors, affect
RT   anaerobic responses in Arabidopsis thaliana.";
RL   Plant J. 62:302-315(2010).
RN   [6]
RP   OXIDATION AT CYS-2.
RX   PubMed=22020279; DOI=10.1038/nature10534;
RA   Gibbs D.J., Lee S.C., Isa N.M., Gramuglia S., Fukao T., Bassel G.W.,
RA   Correia C.S., Corbineau F., Theodoulou F.L., Bailey-Serres J.,
RA   Holdsworth M.J.;
RT   "Homeostatic response to hypoxia is regulated by the N-end rule pathway in
RT   plants.";
RL   Nature 479:415-418(2011).
RN   [7]
RP   FUNCTION, AND INDUCTION BY HYPOXIA.
RX   PubMed=21615413; DOI=10.1111/j.1399-3054.2011.01486.x;
RA   Hess N., Klode M., Anders M., Sauter M.;
RT   "The hypoxia responsive transcription factor genes ERF71/HRE2 and
RT   ERF73/HRE1 of Arabidopsis are differentially regulated by ethylene.";
RL   Physiol. Plantarum 143:41-49(2011).
RN   [8]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=21398256; DOI=10.1104/pp.111.172486;
RA   Yang C.Y., Hsu F.C., Li J.P., Wang N.N., Shih M.C.;
RT   "The AP2/ERF transcription factor AtERF73/HRE1 modulates ethylene responses
RT   during hypoxia in Arabidopsis.";
RL   Plant Physiol. 156:202-212(2011).
RN   [9]
RP   INDUCTION.
RX   PubMed=24395201; DOI=10.1007/s00425-013-2020-z;
RA   Yang C.-Y.;
RT   "Hydrogen peroxide controls transcriptional responses of ERF73/HRE1 and
RT   ADH1 via modulation of ethylene signaling during hypoxic stress.";
RL   Planta 239:877-885(2014).
RN   [10]
RP   FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=24728113; DOI=10.1007/s00299-014-1613-8;
RA   Seok H.Y., Tarte V.N., Lee S.Y., Park H.Y., Moon Y.H.;
RT   "Arabidopsis HRE1alpha, a splicing variant of AtERF73/HRE1, functions as a
RT   nuclear transcription activator in hypoxia response and root development.";
RL   Plant Cell Rep. 33:1255-1262(2014).
RN   [11]
RP   INDUCTION BY ETHYLENE.
RX   PubMed=28698356; DOI=10.1104/pp.17.00555;
RA   Eysholdt-Derzso E., Sauter M.;
RT   "Root bending is antagonistically affected by hypoxia and ERF-mediated
RT   transcription via auxin signaling.";
RL   Plant Physiol. 175:412-423(2017).
RN   [12]
RP   INDUCTION BY HYPOXIA.
RX   PubMed=30535180; DOI=10.1093/aob/mcy202;
RA   Wany A., Gupta A.K., Kumari A., Mishra S., Singh N., Pandey S., Vanvari R.,
RA   Igamberdiev A.U., Fernie A.R., Gupta K.J.;
RT   "Nitrate nutrition influences multiple factors in order to increase energy
RT   efficiency under hypoxia in Arabidopsis.";
RL   Ann. Bot. 123:691-705(2019).
RN   [13]
RP   FUNCTION, ALTERNATIVE SPLICING, AND INDUCTION BY HYPOXIA.
RX   PubMed=32977426; DOI=10.3390/ijms21196984;
RA   Seok H.Y., Ha J., Lee S.Y., Bae H., Moon Y.H.;
RT   "Two alternative splicing variants of AtERF73/HRE1, HRE1alpha and HRE1beta,
RT   have differential transactivation activities in Arabidopsis.";
RL   Int. J. Mol. Sci. 21:0-0(2020).
CC   -!- FUNCTION: Transcriptional activator involved in the hypoxic stress
CC       response (PubMed:20113439, PubMed:21615413, PubMed:21398256,
CC       PubMed:24728113, PubMed:32977426). Acts as a transcriptional activator
CC       via the cis-acting element GCC box (PubMed:24728113, PubMed:32977426).
CC       Plays a role in low oxygen signaling and contributes to tolerance to
CC       anoxia stress by enhancing anaerobic gene expression and ethanolic
CC       fermentation (PubMed:20113439, PubMed:21398256). Invovlved in the
CC       modulation of ethylene responses under both normoxia and hypoxia
CC       (PubMed:21398256). {ECO:0000269|PubMed:20113439,
CC       ECO:0000269|PubMed:21398256, ECO:0000269|PubMed:21615413,
CC       ECO:0000269|PubMed:24728113, ECO:0000269|PubMed:32977426}.
CC   -!- FUNCTION: [Isoform 1]: Is mostly responsible for transactivation of
CC       hypoxia-responsive genes. {ECO:0000269|PubMed:32977426}.
CC   -!- FUNCTION: [Isoform 2]: Involved in root development through the
CC       regulation of root meristem cell division (PubMed:24728113). Does not
CC       act as a transcriptional activator via the cis-acting CRT/DRE element
CC       (PubMed:24728113). {ECO:0000269|PubMed:24728113}.
CC   -!- INTERACTION:
CC       Q8H0T5; O80902: CIPK22; NbExp=4; IntAct=EBI-4475239, EBI-4453230;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00366,
CC       ECO:0000269|PubMed:20113439}.
CC   -!- SUBCELLULAR LOCATION: [Isoform 2]: Nucleus
CC       {ECO:0000269|PubMed:24728113}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=HRE1-beta {ECO:0000303|PubMed:24728113};
CC         IsoId=Q8H0T5-1; Sequence=Displayed;
CC       Name=2; Synonyms=HRE1-alpha {ECO:0000303|PubMed:24728113};
CC         IsoId=Q8H0T5-2; Sequence=VSP_061101;
CC   -!- TISSUE SPECIFICITY: Expressed in roots and at lower levels in shoots.
CC       {ECO:0000269|PubMed:32977426}.
CC   -!- TISSUE SPECIFICITY: [Isoform 2]: Highly expressed in roots and leaf
CC       trichomes (PubMed:24728113). Expressed in rosette leaves, stems,
CC       cauline leaves and flowers (PubMed:24728113).
CC       {ECO:0000269|PubMed:24728113}.
CC   -!- INDUCTION: Induced under hypoxic conditions in roots (PubMed:20113439,
CC       PubMed:21615413, PubMed:21398256, PubMed:24395201, PubMed:24728113,
CC       PubMed:32977426). Induced during hypoxia under nitrate nutrition
CC       (PubMed:30535180). Induced by ethylene (PubMed:21398256,
CC       PubMed:28698356). Induced by hydrogen peroxide (PubMed:24395201).
CC       {ECO:0000269|PubMed:20113439, ECO:0000269|PubMed:21398256,
CC       ECO:0000269|PubMed:21615413, ECO:0000269|PubMed:24395201,
CC       ECO:0000269|PubMed:24728113, ECO:0000269|PubMed:28698356,
CC       ECO:0000269|PubMed:30535180, ECO:0000269|PubMed:32977426}.
CC   -!- PTM: In presence of oxygen, the N-terminal cysteine residue (Cys-2) of
CC       ERF73 can be oxidized by cysteine oxidases, thus preparing the protein
CC       for N-end rule pathway-mediated proteasomal degradation (Probable).
CC       Under low oxygen levels, Cys oxidation is prevented, ERF73 is
CC       stabilized and confers tolerance to hypoxia (Probable).
CC       {ECO:0000305|PubMed:22020279}.
CC   -!- MISCELLANEOUS: Seedlings silencing ERF73 exhibit reduced elongation of
CC       the primary root (PubMed:21398256). Seedlings overexpressing ERF73
CC       exhibit increased elongation of the primary root (PubMed:32977426).
CC       Plants overexpressing ERF73 exhibit increased tolerance to hypoxia
CC       treatment (PubMed:32977426). {ECO:0000269|PubMed:21398256,
CC       ECO:0000269|PubMed:32977426}.
CC   -!- MISCELLANEOUS: [Isoform 2]: Plants overexpressing ERF73 exhibit
CC       increase tolerance to submergence. {ECO:0000269|PubMed:24728113}.
CC   -!- SIMILARITY: Belongs to the AP2/ERF transcription factor family. ERF
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AC016529; AAG52589.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE35310.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE35311.1; -; Genomic_DNA.
DR   EMBL; BT002063; AAN72074.1; -; mRNA.
DR   EMBL; BT006259; AAP13367.1; -; mRNA.
DR   PIR; E96747; E96747.
DR   RefSeq; NP_001077812.1; NM_001084343.2. [Q8H0T5-1]
DR   RefSeq; NP_177380.2; NM_105895.2. [Q8H0T5-1]
DR   AlphaFoldDB; Q8H0T5; -.
DR   SMR; Q8H0T5; -.
DR   BioGRID; 28788; 1.
DR   IntAct; Q8H0T5; 1.
DR   STRING; 3702.AT1G72360.2; -.
DR   PaxDb; Q8H0T5; -.
DR   PRIDE; Q8H0T5; -.
DR   EnsemblPlants; AT1G72360.1; AT1G72360.1; AT1G72360. [Q8H0T5-2]
DR   EnsemblPlants; AT1G72360.2; AT1G72360.2; AT1G72360. [Q8H0T5-1]
DR   GeneID; 843568; -.
DR   Gramene; AT1G72360.1; AT1G72360.1; AT1G72360. [Q8H0T5-2]
DR   Gramene; AT1G72360.2; AT1G72360.2; AT1G72360. [Q8H0T5-1]
DR   KEGG; ath:AT1G72360; -.
DR   Araport; AT1G72360; -.
DR   TAIR; locus:2194007; AT1G72360.
DR   eggNOG; ENOG502QV26; Eukaryota.
DR   HOGENOM; CLU_054468_2_1_1; -.
DR   InParanoid; Q8H0T5; -.
DR   OrthoDB; 1348447at2759; -.
DR   PhylomeDB; Q8H0T5; -.
DR   PRO; PR:Q8H0T5; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q8H0T5; baseline and differential.
DR   Genevisible; Q8H0T5; AT.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR   GO; GO:0071454; P:cellular response to anoxia; IMP:UniProtKB.
DR   GO; GO:0071369; P:cellular response to ethylene stimulus; IMP:UniProtKB.
DR   GO; GO:0071456; P:cellular response to hypoxia; IMP:UniProtKB.
DR   GO; GO:0009873; P:ethylene-activated signaling pathway; IMP:TAIR.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:TAIR.
DR   GO; GO:0034059; P:response to anoxia; IGI:TAIR.
DR   GO; GO:0009723; P:response to ethylene; IEP:TAIR.
DR   GO; GO:0001666; P:response to hypoxia; IEP:TAIR.
DR   CDD; cd00018; AP2; 1.
DR   Gene3D; 3.30.730.10; -; 1.
DR   InterPro; IPR001471; AP2/ERF_dom.
DR   InterPro; IPR036955; AP2/ERF_dom_sf.
DR   InterPro; IPR016177; DNA-bd_dom_sf.
DR   InterPro; IPR044808; ERF_plant.
DR   PANTHER; PTHR31190; PTHR31190; 1.
DR   Pfam; PF00847; AP2; 1.
DR   PRINTS; PR00367; ETHRSPELEMNT.
DR   SMART; SM00380; AP2; 1.
DR   SUPFAM; SSF54171; SSF54171; 1.
DR   PROSITE; PS51032; AP2_ERF; 1.
PE   1: Evidence at protein level;
KW   Activator; Alternative splicing; DNA-binding; Ethylene signaling pathway;
KW   Nucleus; Oxidation; Reference proteome; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..262
FT                   /note="Ethylene-responsive transcription factor ERF073"
FT                   /id="PRO_0000290407"
FT   DNA_BIND        75..132
FT                   /note="AP2/ERF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00366"
FT   REGION          56..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="Cysteine sulfinic acid (-SO2H)"
FT                   /evidence="ECO:0000305|PubMed:22020279"
FT   VAR_SEQ         1..62
FT                   /note="MCGGAVISDYIAPEKIARSSGKSSWRSNGVFDCSIYDFDGNFDELESDEPFV
FT                   FSSTHKHHAS -> MSQSFELYPWL (in isoform 2)"
FT                   /id="VSP_061101"
SQ   SEQUENCE   262 AA;  29094 MW;  458A9FDA23C2FC54 CRC64;
     MCGGAVISDY IAPEKIARSS GKSSWRSNGV FDCSIYDFDG NFDELESDEP FVFSSTHKHH
     ASGSASDGKK KQSSRYKGIR RRPWGRWAAE IRDPIKGVRV WLGTFNTAEE AARAYDLEAK
     RIRGAKAKLN FPNESSGKRK AKAKTVQQVE ENHEADLDVA VVSSAPSSSC LDFLWEENNP
     DTLLIDTQWL EDIIMGDANK KHEPNDSEEA NNVDASLLSE ELLAFENQTE YFSQMPFTEG
     NCDSSTSLSS LFDGGNDMGL WS
 
 
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