ERF99_ARATH
ID ERF99_ARATH Reviewed; 226 AA.
AC Q8L9K1; O22167;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Ethylene-responsive transcription factor 13;
DE Short=AtERF13;
DE AltName: Full=Ethylene-responsive element-binding factor 13;
DE Short=EREBP-13;
GN Name=ERF13; Synonyms=ERF-13, ERF099; OrderedLocusNames=At2g44840;
GN ORFNames=T13E15.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=11950980; DOI=10.1104/pp.010862;
RA Onate-Sanchez L., Singh K.B.;
RT "Identification of Arabidopsis ethylene-responsive element binding factors
RT with distinct induction kinetics after pathogen infection.";
RL Plant Physiol. 128:1313-1322(2002).
RN [6]
RP INDUCTION.
RX PubMed=12068110; DOI=10.1104/pp.002857;
RA Cheong Y.H., Chang H.-S., Gupta R., Wang X., Zhu T., Luan S.;
RT "Transcriptional profiling reveals novel interactions between wounding,
RT pathogen, abiotic stress, and hormonal responses in Arabidopsis.";
RL Plant Physiol. 129:661-677(2002).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16407444; DOI=10.1104/pp.105.073783;
RA Nakano T., Suzuki K., Fujimura T., Shinshi H.;
RT "Genome-wide analysis of the ERF gene family in Arabidopsis and rice.";
RL Plant Physiol. 140:411-432(2006).
CC -!- FUNCTION: Acts as a transcriptional activator. Binds to the GCC-box
CC pathogenesis-related promoter element. Involved in the regulation of
CC gene expression by stress factors and by components of stress signal
CC transduction pathways. {ECO:0000269|PubMed:11950980}.
CC -!- INTERACTION:
CC Q8L9K1; A0A178WAA1: At1g10650; NbExp=3; IntAct=EBI-15204728, EBI-25517084;
CC Q8L9K1; Q9CAW4: At3g05000; NbExp=3; IntAct=EBI-15204728, EBI-25516228;
CC Q8L9K1; F4JL11: IMPA2; NbExp=3; IntAct=EBI-15204728, EBI-1253508;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed after ethylene treatment.
CC {ECO:0000269|PubMed:11950980}.
CC -!- INDUCTION: Strongly induced by wounding. Induced by Pseudomonas
CC syringae tomato (both virulent and avirulent avrRpt2 strains),
CC independently of PAD4. Also induced by methyl jasmonate (MeJA)
CC independently of JAR1, but seems to not be affected by ethylene.
CC Induction by salicylic acid (SA) is controlled by growth and/or
CC developmental conditions, and seems to be more efficient and
CC independent of PAD4 in older plants. {ECO:0000269|PubMed:11950980,
CC ECO:0000269|PubMed:12068110}.
CC -!- SIMILARITY: Belongs to the AP2/ERF transcription factor family. ERF
CC subfamily. {ECO:0000305}.
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DR EMBL; AC002388; AAC31840.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10473.1; -; Genomic_DNA.
DR EMBL; AF325089; AAK17157.1; -; mRNA.
DR EMBL; AF370540; AAK48967.1; -; mRNA.
DR EMBL; AY072471; AAL66886.1; -; mRNA.
DR EMBL; AY088387; AAM65925.1; -; mRNA.
DR PIR; T00409; T00409.
DR RefSeq; NP_182011.1; NM_130048.3.
DR AlphaFoldDB; Q8L9K1; -.
DR SMR; Q8L9K1; -.
DR BioGRID; 4429; 7.
DR IntAct; Q8L9K1; 4.
DR STRING; 3702.AT2G44840.1; -.
DR iPTMnet; Q8L9K1; -.
DR PaxDb; Q8L9K1; -.
DR PRIDE; Q8L9K1; -.
DR ProteomicsDB; 220690; -.
DR EnsemblPlants; AT2G44840.1; AT2G44840.1; AT2G44840.
DR GeneID; 819093; -.
DR Gramene; AT2G44840.1; AT2G44840.1; AT2G44840.
DR KEGG; ath:AT2G44840; -.
DR Araport; AT2G44840; -.
DR TAIR; locus:2055002; AT2G44840.
DR eggNOG; ENOG502SNQ8; Eukaryota.
DR HOGENOM; CLU_058713_3_0_1; -.
DR InParanoid; Q8L9K1; -.
DR OMA; QKRESHV; -.
DR OrthoDB; 1470222at2759; -.
DR PhylomeDB; Q8L9K1; -.
DR PRO; PR:Q8L9K1; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8L9K1; baseline and differential.
DR Genevisible; Q8L9K1; AT.
DR GO; GO:0005634; C:nucleus; HDA:TAIR.
DR GO; GO:0003677; F:DNA binding; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0009873; P:ethylene-activated signaling pathway; TAS:TAIR.
DR CDD; cd00018; AP2; 1.
DR Gene3D; 3.30.730.10; -; 1.
DR InterPro; IPR001471; AP2/ERF_dom.
DR InterPro; IPR036955; AP2/ERF_dom_sf.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR044808; ERF_plant.
DR PANTHER; PTHR31190; PTHR31190; 1.
DR Pfam; PF00847; AP2; 1.
DR PRINTS; PR00367; ETHRSPELEMNT.
DR SMART; SM00380; AP2; 1.
DR SUPFAM; SSF54171; SSF54171; 1.
DR PROSITE; PS51032; AP2_ERF; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Ethylene signaling pathway; Nucleus; Plant defense;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..226
FT /note="Ethylene-responsive transcription factor 13"
FT /id="PRO_0000112549"
FT DNA_BIND 91..149
FT /note="AP2/ERF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00366"
FT REGION 57..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 96..112
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 177..191
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 57
FT /note="G -> A (in Ref. 4; AAM65925)"
FT /evidence="ECO:0000305"
FT CONFLICT 72
FT /note="N -> D (in Ref. 4; AAM65925)"
FT /evidence="ECO:0000305"
FT CONFLICT 191
FT /note="E -> K (in Ref. 4; AAM65925)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 226 AA; 25353 MW; 4B2EF81CDD856987 CRC64;
MSSSDSVNNG VNSRMYFRNP SFSNVILNDN WSDLPLSVDD SQDMAIYNTL RDAVSSGWTP
SVPPVTSPAE ENKPPATKAS GSHAPRQKGM QYRGVRRRPW GKFAAEIRDP KKNGARVWLG
TYETPEDAAV AYDRAAFQLR GSKAKLNFPH LIGSCKYEPV RIRPRRRSPE PSVSDQLTSE
QKRESHVDDG ESSLVVPELD FTVDQFYFDG SLLMDQSECS YSDNRI
