位置:首页 > 蛋白库 > ERFB_DEBHA
ERFB_DEBHA
ID   ERFB_DEBHA              Reviewed;         371 AA.
AC   Q6BHT4;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Palmitoyltransferase ERF2;
DE            EC=2.3.1.225 {ECO:0000250|UniProtKB:Q8VDZ4};
DE   AltName: Full=DHHC cysteine-rich domain-containing protein ERF2;
DE   AltName: Full=Ras protein acyltransferase;
GN   Name=ERF2; OrderedLocusNames=DEHA2G15972g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: The ERF2-ERF4 complex is a palmitoyltransferase specific for
CC       Ras proteins. {ECO:0000250|UniProtKB:Q06551}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC         hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC         COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC         EC=2.3.1.225; Evidence={ECO:0000250|UniProtKB:Q8VDZ4};
CC   -!- SUBUNIT: Interacts with ERF4. {ECO:0000250|UniProtKB:Q06551}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q06551}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q06551}.
CC   -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC       {ECO:0000250|UniProtKB:Q06551}.
CC   -!- PTM: Autopalmitoylated. {ECO:0000250|UniProtKB:Q9UIJ5}.
CC   -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC       ERF2/ZDHHC9 subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382139; CAG90733.2; -; Genomic_DNA.
DR   RefSeq; XP_462237.2; XM_462237.1.
DR   AlphaFoldDB; Q6BHT4; -.
DR   SMR; Q6BHT4; -.
DR   STRING; 4959.XP_462237.2; -.
DR   EnsemblFungi; CAG90733; CAG90733; DEHA2G15972g.
DR   GeneID; 2905161; -.
DR   KEGG; dha:DEHA2G15972g; -.
DR   VEuPathDB; FungiDB:DEHA2G15972g; -.
DR   eggNOG; KOG1311; Eukaryota.
DR   HOGENOM; CLU_047581_1_0_1; -.
DR   InParanoid; Q6BHT4; -.
DR   OMA; KNLYINW; -.
DR   OrthoDB; 1264614at2759; -.
DR   Proteomes; UP000000599; Chromosome G.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR   Pfam; PF01529; DHHC; 1.
DR   PROSITE; PS50216; DHHC; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Endoplasmic reticulum; Lipoprotein; Membrane; Palmitate;
KW   Reference proteome; Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..371
FT                   /note="Palmitoyltransferase ERF2"
FT                   /id="PRO_0000212941"
FT   TOPO_DOM        1..79
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        101..106
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        128..225
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        247..274
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        296..371
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          181..231
FT                   /note="DHHC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00067"
FT   ACT_SITE        211
FT                   /note="S-palmitoyl cysteine intermediate"
FT                   /evidence="ECO:0000250|UniProtKB:Q8VDZ4"
SQ   SEQUENCE   371 AA;  43141 MW;  1DF571158B778855 CRC64;
     MSRRERYSVE PIPNDANEFQ DNVSFIHKFI TNWLITDPSL RNPGSEKNVK AKNYQVQKHE
     NVQFIYLCGG RLRSVKQKPI NVVTGISILI PGILFWIFEA KWIWFHVNPS IVILFSYFWL
     ITVSFFIKAS MSDPGMLPRN IHVPYSISNA NTSPKASPPD EYFNIISLPY NAEDHTGVGL
     KYCATCHIWR SPRASHCSVC NSCIISHDHH CVFLNNCIGY RNYKYFLWFL LFAVLGCILM
     SVISFIHVFY YRLGMETSVS TFRSSISKYP VSFLLCIYSL LALVYPFPLL IFHIFLTSYN
     LTTREYFNNV RGVKNSQNHF TNHFDTHSIF KNLYINWLGR ARGFSLVRQT DSYQIGDLRF
     EKLDPLQSFS S
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2025