AGR2A_XENLA
ID AGR2A_XENLA Reviewed; 159 AA.
AC Q90Y05;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Anterior gradient protein 2-A;
DE Short=XAgr2 {ECO:0000303|PubMed:12711553};
DE AltName: Full=Cement gland-specific protein CGS {ECO:0000312|EMBL:AAL26844.1};
DE Flags: Precursor;
GN Name=agr2-a; Synonyms=agr2 {ECO:0000303|PubMed:12711553};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAL26844.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Embryo {ECO:0000269|PubMed:12711553};
RX PubMed=12711553; DOI=10.1016/s1567-133x(02)00077-7;
RA Novoselov V.V., Alexandrova E.M., Ermakova G.V., Zaraisky A.G.;
RT "Expression zones of three novel genes abut the developing anterior neural
RT plate of Xenopus embryo.";
RL Gene Expr. Patterns 3:225-230(2003).
RN [2] {ECO:0000312|EMBL:AAI28957.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin {ECO:0000312|EMBL:AAI28957.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Monomer and homodimer. {ECO:0000250|UniProtKB:O95994}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255, ECO:0000305}. Endoplasmic
CC reticulum {ECO:0000250|UniProtKB:O88312}.
CC -!- TISSUE SPECIFICITY: Expression begins at the end of gastrulation within
CC the anterior ectoderm and by the end of neurulation is located within
CC the cement gland placode. At stage 32 (tailbud), expressed in the cells
CC surrounding the cement gland and in the otic vesicle. In addition, at
CC the end of neurulation and afterwards, expressed within the notochord.
CC {ECO:0000269|PubMed:12711553}.
CC -!- SIMILARITY: Belongs to the AGR family. {ECO:0000255}.
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DR EMBL; AF314056; AAL26844.1; -; mRNA.
DR EMBL; BC128956; AAI28957.1; -; mRNA.
DR RefSeq; NP_001082165.1; NM_001088696.1.
DR AlphaFoldDB; Q90Y05; -.
DR SMR; Q90Y05; -.
DR DNASU; 398260; -.
DR GeneID; 398260; -.
DR KEGG; xla:398260; -.
DR CTD; 398260; -.
DR Xenbase; XB-GENE-17332659; agr2.S.
DR OMA; PTFMITR; -.
DR OrthoDB; 1382017at2759; -.
DR Proteomes; UP000186698; Chromosome 6S.
DR Bgee; 398260; Expressed in internal ear and 16 other tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR GO; GO:0010811; P:positive regulation of cell-substrate adhesion; ISS:UniProtKB.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000250|UniProtKB:O95994"
FT CHAIN 21..159
FT /note="Anterior gradient protein 2-A"
FT /evidence="ECO:0000255"
FT /id="PRO_0000392578"
FT MOTIF 29..38
FT /note="Homodimer stabilization; interchain"
FT /evidence="ECO:0000250|UniProtKB:O95994"
FT MOTIF 44..51
FT /note="Homodimer stabilization; interchain"
FT /evidence="ECO:0000250|UniProtKB:O95994"
SQ SEQUENCE 159 AA; 18275 MW; 738D62284838B8EB CRC64;
METVLKSLFF LLVATSFTLA KERKPQTLSR GWGDNLEWVQ TYEEGLFKAK SENKPLLLIN
HRNDCPHSQA LKKAFAEHQG IQKLAEEFIL LNVVYDPTDK NLQLDGQYVP KVVFVDPSLV
VRADLPGKYS NHQYTYEPAD IDHLFENMKK ALVLLKTEL
