ID   ERFD_ASHGO              Reviewed;         237 AA.
AC   Q758G1;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Ras modification protein ERF4;
GN   Name=ERF4; OrderedLocusNames=AEL199W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO C-TERMINUS.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: The ERF2-ERF4 complex is a palmitoyltransferase specific for
CC       Ras proteins. Palmitoylates RAS2, which is required for its proper
CC       plasma membrane localization (By similarity).
CC       {ECO:0000250|UniProtKB:P41912}.
CC   -!- SUBUNIT: Interacts with ERF2. {ECO:0000250|UniProtKB:P41912}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:P41912}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P41912}.
CC   -!- SIMILARITY: Belongs to the ERF4 family. {ECO:0000305}.
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DR   EMBL; AE016818; AAS52486.2; -; Genomic_DNA.
DR   RefSeq; NP_984662.2; NM_210015.2.
DR   AlphaFoldDB; Q758G1; -.
DR   STRING; 33169.AAS52486; -.
DR   EnsemblFungi; AAS52486; AAS52486; AGOS_AEL199W.
DR   GeneID; 4620844; -.
DR   KEGG; ago:AGOS_AEL199W; -.
DR   eggNOG; ENOG502S30T; Eukaryota.
DR   HOGENOM; CLU_087349_0_0_1; -.
DR   InParanoid; Q758G1; -.
DR   OMA; CITHFPN; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0031211; C:endoplasmic reticulum palmitoyltransferase complex; IBA:GO_Central.
DR   GO; GO:0042406; C:extrinsic component of endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0002178; C:palmitoyltransferase complex; IBA:GO_Central.
DR   GO; GO:0016409; F:palmitoyltransferase activity; IEA:EnsemblFungi.
DR   GO; GO:0018230; P:peptidyl-L-cysteine S-palmitoylation; IBA:GO_Central.
DR   GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR   InterPro; IPR019383; Golgin_A_7/ERF4.
DR   Pfam; PF10256; Erf4; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome.
FT   CHAIN           1..237
FT                   /note="Ras modification protein ERF4"
FT                   /id="PRO_0000213981"
SQ   SEQUENCE   237 AA;  27248 MW;  18D5B87176FBCDA3 CRC64;
     MPKSEATEAT GSKSGPDLLE GGNNPLFFNC HEFLVTKYRE LGEEVVREHT EDEALCITHF
     PNIYCPQGSV EFDRTRIVRL PRRFEESMHY PSFSTELPGH EPAALQREDE ARFTPAGFHD
     GHVFGRSSLS PLSNYVSPEE CRDVVRAING YLKEAYRVQG TQNILFNALD VLTFYTVSLL
     LSYFRRRTQL EQLEDYVEEV NERFFEKRGI RIISPRRSAY LSLDIQIPRP VPPAARS