ERFD_CANAL
ID ERFD_CANAL Reviewed; 218 AA.
AC Q5A1U8; A0A1D8PN33; Q5A1P1;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 3.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Ras modification protein ERF4;
GN Name=ERF4; Synonyms=SHR5; OrderedLocusNames=CAALFM_C501170WA;
GN ORFNames=CaO19.1955, CaO19.9510;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: The ERF2-ERF4 complex is a palmitoyltransferase specific for
CC Ras proteins. Palmitoylates RAS2, which is required for its proper
CC plasma membrane localization (By similarity).
CC {ECO:0000250|UniProtKB:P41912}.
CC -!- SUBUNIT: Interacts with ERF2. {ECO:0000250|UniProtKB:P41912}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:P41912}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P41912}.
CC -!- SIMILARITY: Belongs to the ERF4 family. {ECO:0000305}.
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DR EMBL; CP017627; AOW29552.1; -; Genomic_DNA.
DR RefSeq; XP_019330955.1; XM_019475410.1.
DR AlphaFoldDB; Q5A1U8; -.
DR STRING; 237561.Q5A1U8; -.
DR GeneID; 3642662; -.
DR KEGG; cal:CAALFM_C501170WA; -.
DR CGD; CAL0000178317; orf19.9510.
DR VEuPathDB; FungiDB:C5_01170W_A; -.
DR eggNOG; ENOG502S30T; Eukaryota.
DR HOGENOM; CLU_087349_0_0_1; -.
DR InParanoid; Q5A1U8; -.
DR OMA; CITHFPN; -.
DR OrthoDB; 1305531at2759; -.
DR PRO; PR:Q5A1U8; -.
DR Proteomes; UP000000559; Chromosome 5.
DR GO; GO:0031211; C:endoplasmic reticulum palmitoyltransferase complex; IBA:GO_Central.
DR GO; GO:0042406; C:extrinsic component of endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0002178; C:palmitoyltransferase complex; IBA:GO_Central.
DR GO; GO:0018230; P:peptidyl-L-cysteine S-palmitoylation; IBA:GO_Central.
DR GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR InterPro; IPR019383; Golgin_A_7/ERF4.
DR Pfam; PF10256; Erf4; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Membrane; Reference proteome.
FT CHAIN 1..218
FT /note="Ras modification protein ERF4"
FT /id="PRO_0000213982"
SQ SEQUENCE 218 AA; 24666 MW; 3AD6A1566D1DD8F8 CRC64;
MNETKTDSTV NPDQSSQELV FFNYHEYLVP GSDDTSLVIN HFPNIHTDLS SSTFKETRII
RIPRVYHTVQ FPDLIPQFSC YYPGSEPGAI TSTQLMSGSF DDNSFNESSS IPSLENIISR
SEFENIVSLV NESLAVAFNP MSKRMLLENL LDLLSGGLFL SLLNFLGIYS FTKRKLMELE
SQIDSINQIN EKKGVDFKII SPRVTGYLSL DFQITKPR