ID   ERFD_CANGA              Reviewed;         265 AA.
AC   Q6FVF9;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Ras modification protein ERF4;
GN   Name=ERF4; OrderedLocusNames=CAGL0E02189g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: The ERF2-ERF4 complex is a palmitoyltransferase specific for
CC       Ras proteins. Palmitoylates RAS2, which is required for its proper
CC       plasma membrane localization (By similarity).
CC       {ECO:0000250|UniProtKB:P41912}.
CC   -!- SUBUNIT: Interacts with ERF2. {ECO:0000250|UniProtKB:P41912}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:P41912}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P41912}.
CC   -!- SIMILARITY: Belongs to the ERF4 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR380951; CAG58704.2; -; Genomic_DNA.
DR   RefSeq; XP_445785.2; XM_445785.2.
DR   AlphaFoldDB; Q6FVF9; -.
DR   STRING; 5478.XP_445785.2; -.
DR   EnsemblFungi; CAG58704; CAG58704; CAGL0E02189g.
DR   GeneID; 2887281; -.
DR   KEGG; cgr:CAGL0E02189g; -.
DR   eggNOG; ENOG502S30T; Eukaryota.
DR   HOGENOM; CLU_087349_0_0_1; -.
DR   InParanoid; Q6FVF9; -.
DR   OMA; CITHFPN; -.
DR   Proteomes; UP000002428; Chromosome E.
DR   GO; GO:0031211; C:endoplasmic reticulum palmitoyltransferase complex; IEA:EnsemblFungi.
DR   GO; GO:0042406; C:extrinsic component of endoplasmic reticulum membrane; IEA:EnsemblFungi.
DR   GO; GO:0016409; F:palmitoyltransferase activity; IEA:EnsemblFungi.
DR   GO; GO:0018230; P:peptidyl-L-cysteine S-palmitoylation; IEA:EnsemblFungi.
DR   GO; GO:0006612; P:protein targeting to membrane; IEA:EnsemblFungi.
DR   InterPro; IPR019383; Golgin_A_7/ERF4.
DR   Pfam; PF10256; Erf4; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome.
FT   CHAIN           1..265
FT                   /note="Ras modification protein ERF4"
FT                   /id="PRO_0000213983"
SQ   SEQUENCE   265 AA;  30455 MW;  3E1C3F20DBF03C8E CRC64;
     MYTDLEDNEN RFYTNSDVIL EEGTLGSSLG RSSRRTHEKG EDVQDPVFFN VHEVTESYFA
     DITNPTVFRD HDEDHSLCVT HFMNVYASQD SRLFEETRVV RIPRRFDMGN RWYPMFSDLL
     PGSEPGAILH DTDGLQFVPR GITQDGNVYG YSSVSPLSLY LTQQHFQEIV TTINDILLAT
     YSTYGFYNIL NIILEVFTLG LWSYVCKRIN YALSIDPMKR LDVYVRELNA SPAFVEAQIK
     LINPRDSGFL SLDFQIPKPK SISTQ