ID   AGR2B_XENLA             Reviewed;         164 AA.
AC   Q7ZZH4;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Anterior gradient protein 2-B;
DE   Flags: Precursor;
GN   Name=agr2-b; Synonyms=agr2 {ECO:0000312|EMBL:AAH52102.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH52102.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tail bud {ECO:0000312|EMBL:AAH52102.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Monomer and homodimer. {ECO:0000250|UniProtKB:O95994}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255, ECO:0000305}. Endoplasmic
CC       reticulum {ECO:0000250|UniProtKB:O88312}.
CC   -!- SIMILARITY: Belongs to the AGR family. {ECO:0000255}.
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DR   EMBL; BC052102; AAH52102.1; -; mRNA.
DR   RefSeq; NP_001079720.1; NM_001086251.1.
DR   AlphaFoldDB; Q7ZZH4; -.
DR   SMR; Q7ZZH4; -.
DR   GeneID; 379407; -.
DR   KEGG; xla:379407; -.
DR   CTD; 379407; -.
DR   Xenbase; XB-GENE-971554; agr2.L.
DR   OMA; CAMEEIS; -.
DR   OrthoDB; 1382017at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 379407; Expressed in neurula embryo and 12 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR   GO; GO:0010811; P:positive regulation of cell-substrate adhesion; ISS:UniProtKB.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250|UniProtKB:O95994"
FT   CHAIN           21..164
FT                   /note="Anterior gradient protein 2-B"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000392579"
FT   MOTIF           34..43
FT                   /note="Homodimer stabilization; interchain"
FT                   /evidence="ECO:0000250|UniProtKB:O95994"
FT   MOTIF           49..56
FT                   /note="Homodimer stabilization; interchain"
FT                   /evidence="ECO:0000250|UniProtKB:O95994"
SQ   SEQUENCE   164 AA;  18684 MW;  8C626DDA5A31D46C CRC64;
     MESVLKSLFV LLVATSFTLA KEIPAKVSKP QTLSRGWGDN LEWVQTYEEG LYKAKAENKP
     LMLINHRNDC PHSLALKKAF AEHQGIQKLA EEFILLNVVY DPTDKNLQLD GQYVPKIIFV
     DPSLVVRADL PGKYSNHQYT YEPADIDHLF ENMKKALVLL KTEL