ID   ERFD_DEBHA              Reviewed;         253 AA.
AC   Q6BPN7;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Ras modification protein ERF4;
GN   Name=ERF4; OrderedLocusNames=DEHA2E12122g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: The ERF2-ERF4 complex is a palmitoyltransferase specific for
CC       Ras proteins. Palmitoylates RAS2, which is required for its proper
CC       plasma membrane localization (By similarity).
CC       {ECO:0000250|UniProtKB:P41912}.
CC   -!- SUBUNIT: Interacts with ERF2. {ECO:0000250|UniProtKB:P41912}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:P41912}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P41912}.
CC   -!- SIMILARITY: Belongs to the ERF4 family. {ECO:0000305}.
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DR   EMBL; CR382137; CAG88072.2; -; Genomic_DNA.
DR   RefSeq; XP_459833.2; XM_459833.1.
DR   AlphaFoldDB; Q6BPN7; -.
DR   STRING; 4959.XP_459833.2; -.
DR   EnsemblFungi; CAG88072; CAG88072; DEHA2E12122g.
DR   GeneID; 2901905; -.
DR   KEGG; dha:DEHA2E12122g; -.
DR   VEuPathDB; FungiDB:DEHA2E12122g; -.
DR   eggNOG; ENOG502S30T; Eukaryota.
DR   HOGENOM; CLU_087349_0_0_1; -.
DR   InParanoid; Q6BPN7; -.
DR   OMA; CITHFPN; -.
DR   OrthoDB; 1305531at2759; -.
DR   Proteomes; UP000000599; Chromosome E.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019383; Golgin_A_7/ERF4.
DR   Pfam; PF10256; Erf4; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome.
FT   CHAIN           1..253
FT                   /note="Ras modification protein ERF4"
FT                   /id="PRO_0000213984"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   253 AA;  29168 MW;  E62AE68DB8ED5CE3 CRC64;
     MQESSTKHVV KEDNITNNGE NENNGITEPL LFFNYHEFLT ENYNVHPSCR HNSKARSIVV
     NHFPNNHVPI DSSMYSDTRI VRIPRIFNTI QLSDIIPQFS NYTPGTEPAA INDQQGFTFK
     PVGIYDNNSF GETSVTPLVP GYMTEEEFHT IIDNINKYLH EAFSPYNVWN LFDSILDLLS
     ANFYNKIVNN FLVDTYSKRK LLELEMYIEN DINLGMFASR PGLKILSPRK SGYLSVCIDY
     YNSHQNHCTN YLA