ID   ERFD_SCHPO              Reviewed;         172 AA.
AC   Q10182;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Ras modification protein erf4;
DE   AltName: Full=Meiotically up-regulated gene 91 protein;
GN   Name=erf4; Synonyms=mug91; ORFNames=SPAC3F10.07c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   FUNCTION IN MEIOSIS.
RX   PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA   Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA   Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA   Smith G.R., Moreno S.;
RT   "A large-scale screen in S. pombe identifies seven novel genes required for
RT   critical meiotic events.";
RL   Curr. Biol. 15:2056-2062(2005).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
RN   [4]
RP   FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX   PubMed=23843742; DOI=10.1371/journal.pbio.1001597;
RA   Zhang M.M., Wu P.Y., Kelly F.D., Nurse P., Hang H.C.;
RT   "Quantitative control of protein S-palmitoylation regulates meiotic entry
RT   in fission yeast.";
RL   PLoS Biol. 11:e1001597-e1001597(2013).
CC   -!- FUNCTION: The erf2-erf4 complex is a palmitoyltransferase with a major
CC       role in driving sexual development (PubMed:23843742, PubMed:16303567).
CC       Palmitoylates ras1 (PubMed:23843742). Palmitoylates isp3
CC       (PubMed:23843742). Palmitoylates rho3 (PubMed:23843742).
CC       {ECO:0000269|PubMed:16303567, ECO:0000269|PubMed:23843742}.
CC   -!- SUBUNIT: Interacts with erf2. {ECO:0000250|UniProtKB:P41912}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:16823372}; Peripheral membrane protein
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- DEVELOPMENTAL STAGE: Expressed during meiosis.
CC       {ECO:0000269|PubMed:23843742}.
CC   -!- DISRUPTION PHENOTYPE: Abolishes palmitoylation of ras1 during
CC       vegetative growth. {ECO:0000269|PubMed:23843742}.
CC   -!- SIMILARITY: Belongs to the ERF4 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAA93305.1; -; Genomic_DNA.
DR   PIR; T38708; T38708.
DR   RefSeq; NP_593939.1; NM_001019367.1.
DR   AlphaFoldDB; Q10182; -.
DR   BioGRID; 279545; 42.
DR   STRING; 4896.SPAC3F10.07c.1; -.
DR   PaxDb; Q10182; -.
DR   EnsemblFungi; SPAC3F10.07c.1; SPAC3F10.07c.1:pep; SPAC3F10.07c.
DR   GeneID; 2543113; -.
DR   KEGG; spo:SPAC3F10.07c; -.
DR   PomBase; SPAC3F10.07c; erf4.
DR   VEuPathDB; FungiDB:SPAC3F10.07c; -.
DR   HOGENOM; CLU_1556154_0_0_1; -.
DR   InParanoid; Q10182; -.
DR   OMA; YASEFVF; -.
DR   PhylomeDB; Q10182; -.
DR   Reactome; R-SPO-6798695; Neutrophil degranulation.
DR   PRO; PR:Q10182; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR   GO; GO:0031211; C:endoplasmic reticulum palmitoyltransferase complex; ISO:PomBase.
DR   GO; GO:0042406; C:extrinsic component of endoplasmic reticulum membrane; ISO:PomBase.
DR   GO; GO:0002178; C:palmitoyltransferase complex; IBA:GO_Central.
DR   GO; GO:0061951; P:establishment of protein localization to plasma membrane; IC:PomBase.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0018230; P:peptidyl-L-cysteine S-palmitoylation; IBA:GO_Central.
DR   GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR   InterPro; IPR019383; Golgin_A_7/ERF4.
DR   Pfam; PF10256; Erf4; 1.
PE   1: Evidence at protein level;
KW   Endoplasmic reticulum; Meiosis; Membrane; Reference proteome.
FT   CHAIN           1..172
FT                   /note="Ras modification protein erf4"
FT                   /id="PRO_0000213986"
FT   REGION          152..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   172 AA;  19595 MW;  BB3F18D554F6EF96 CRC64;
     MLVRIERDYS VSGDKYPQFP TDYPVPLRAY VNLEDWDVFI HTLNEKLREA FCPWSIGNLL
     DGILSVLTIY ISEFVFGSIH RKRIGAIDLY ILDFATQHNL YVASLRNMGF LSLVFHTKET
     NSKSSTLHSN PYCPEHHSIR TLPSAVTATT SNISTSSSHR SDLPNEWTNS TL