ID   ERFD_YARLI              Reviewed;         180 AA.
AC   P0C0R1; B5FVH0;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Ras modification protein ERF4;
GN   Name=ERF4; OrderedLocusNames=YALI0E02827g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: The ERF2-ERF4 complex is a palmitoyltransferase specific for
CC       Ras proteins. Palmitoylates RAS2, which is required for its proper
CC       plasma membrane localization (By similarity).
CC       {ECO:0000250|UniProtKB:P41912}.
CC   -!- SUBUNIT: Interacts with ERF2. {ECO:0000250|UniProtKB:P41912}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:P41912}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P41912}.
CC   -!- SIMILARITY: Belongs to the ERF4 family. {ECO:0000305}.
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DR   EMBL; CR382131; CAR64324.1; -; Genomic_DNA.
DR   RefSeq; XP_002143061.1; XM_002143025.1.
DR   AlphaFoldDB; P0C0R1; -.
DR   STRING; 4952.CAR64324; -.
DR   EnsemblFungi; CAR64324; CAR64324; YALI0_E02827g.
DR   GeneID; 7009536; -.
DR   KEGG; yli:YALI0E02827g; -.
DR   VEuPathDB; FungiDB:YALI0_E02827g; -.
DR   HOGENOM; CLU_087349_0_0_1; -.
DR   InParanoid; P0C0R1; -.
DR   OMA; YASEFVF; -.
DR   Proteomes; UP000001300; Chromosome E.
DR   GO; GO:0031211; C:endoplasmic reticulum palmitoyltransferase complex; IBA:GO_Central.
DR   GO; GO:0042406; C:extrinsic component of endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0002178; C:palmitoyltransferase complex; IBA:GO_Central.
DR   GO; GO:0018230; P:peptidyl-L-cysteine S-palmitoylation; IBA:GO_Central.
DR   GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR   InterPro; IPR019383; Golgin_A_7/ERF4.
DR   Pfam; PF10256; Erf4; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome.
FT   CHAIN           1..180
FT                   /note="Ras modification protein ERF4"
FT                   /id="PRO_0000213987"
SQ   SEQUENCE   180 AA;  21070 MW;  9460F81A99FD9F20 CRC64;
     MTSFFNYHEY ISSNDRAQTH HPNIYVEYGQ SDTKLRRCVR VPRDYSVVGD EYPYFSTHFV
     GEEPGAYPSE EGPTYDSRSP LKDIISYQEY NDIVGTINGY MKRAFSPWQK CQFIETVLSF
     LTLWIFERLF ASNNERVLAQ LDEYIDQLNS KNADRFILIN PRKNGFLSLD FLVMVGEPNI