ID   ERFL_HUMAN              Reviewed;         354 AA.
AC   A0A1W2PQ73;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2017, sequence version 1.
DT   03-AUG-2022, entry version 27.
DE   RecName: Full=ETS domain-containing transcription factor ERF-like {ECO:0000305};
DE   AltName: Full=ETS repressor factor-like {ECO:0000312|HGNC:HGNC:53894};
GN   Name=ERFL {ECO:0000312|HGNC:HGNC:53894};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR   EMBL; AC010616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC243967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A1W2PQ73; -.
DR   SMR; A0A1W2PQ73; -.
DR   BioMuta; ENSG00000268041; -.
DR   MassIVE; A0A1W2PQ73; -.
DR   PeptideAtlas; A0A1W2PQ73; -.
DR   Ensembl; ENST00000597630.3; ENSP00000491574.1; ENSG00000268041.3.
DR   MANE-Select; ENST00000597630.3; ENSP00000491574.1; NM_001365103.2; NP_001352032.1.
DR   GeneCards; ERFL; -.
DR   HGNC; HGNC:53894; ERFL.
DR   HPA; ENSG00000268041; Tissue enhanced (intestine, lymphoid tissue).
DR   neXtProt; NX_A0A1W2PQ73; -.
DR   VEuPathDB; HostDB:ENSG00000268041; -.
DR   GeneTree; ENSGT00940000163212; -.
DR   OMA; YSRAFPE; -.
DR   ChiTaRS; LOC390937; human.
DR   PRO; PR:A0A1W2PQ73; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; A0A1W2PQ73; protein.
DR   Bgee; ENSG00000268041; Expressed in granulocyte and 78 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; PTHR11849; 1.
DR   Pfam; PF00178; Ets; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..354
FT                   /note="ETS domain-containing transcription factor ERF-like"
FT                   /id="PRO_0000448269"
FT   DNA_BIND        42..122
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT   REGION          263..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   354 AA;  37790 MW;  34B068BD98AFC471 CRC64;
     MDCSCVSDLL FAPPALPALW TPGFAFPDWA YKPESSPGSR QIQLWHFILE LLQKEEYQGV
     IAWQGDYGEF VIKDPDEVAR LWGIRKCKPH MNYDKLSRAL RYYYNKRILH KTKGKRFTYK
     FNFSKVVLVN YPLLDMAAAA TGSPLLLTPS PFGGAPGPDA PPLTPETLQT LFSAPRLGEP
     GARTPLFTSE TDKLRLDSPF PFLGSGATSY SKPPGLLGPY GRAFPEYPWN FNPYLTGPFP
     KLPPSLYPPH FYPNPLASSL GHLPSSGAGG GPTATPLLAS TGEGLGPERP SGLAAAPRLA
     LPGAGGPEAA LGGKEDSDSE LEITDVSGCS SDSEGDEGLP APPKAKAGKG GTGS