AGR2_DANRE
ID AGR2_DANRE Reviewed; 171 AA.
AC Q5RZ65; A7MCE1;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Anterior gradient protein 2 homolog;
DE Short=Zagr2;
DE Flags: Precursor;
GN Name=agr2 {ECO:0000312|ZFIN:ZDB-GENE-050417-214};
GN ORFNames=si:ch211-201m19.5, wu:fj29g05, zgc:112187;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAV65516.1}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=17175205; DOI=10.1016/j.modgep.2006.11.003;
RA Shih L.-J., Lu Y.-F., Chen Y.-H., Lin C.-C., Chen J.-A., Hwang S.-P.L.;
RT "Characterization of the agr2 gene, a homologue of X. laevis anterior
RT gradient 2, from the zebrafish, Danio rerio.";
RL Gene Expr. Patterns 7:452-460(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000312|EMBL:CAM56358.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye {ECO:0000312|EMBL:AAI52145.1}, and
RC Larva {ECO:0000312|EMBL:AAH93250.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Monomer and homodimer. {ECO:0000250|UniProtKB:O95994}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255, ECO:0000305}. Endoplasmic
CC reticulum {ECO:0000250|UniProtKB:O88312}.
CC -!- TISSUE SPECIFICITY: Expressed in most developing organs which contain
CC mucus-secreting cells, including the epidermis, olfactory bulbs, otic
CC vesicles, pharynx, esophagus, pneumatic duct, swim bladder, and
CC intestine. Expressed in the gill, pharynx/esophagus, swim
CC bladder/pneumatic duct, and intestine in the adult.
CC {ECO:0000269|PubMed:17175205}.
CC -!- DEVELOPMENTAL STAGE: Expressed after the segmentation stage.
CC {ECO:0000269|PubMed:17175205}.
CC -!- SIMILARITY: Belongs to the AGR family. {ECO:0000255}.
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DR EMBL; AY796218; AAV65516.1; -; mRNA.
DR EMBL; BX547939; CAM56358.1; -; Genomic_DNA.
DR EMBL; BC093250; AAH93250.1; -; mRNA.
DR EMBL; BC152144; AAI52145.1; -; mRNA.
DR RefSeq; NP_001012499.1; NM_001012481.2.
DR AlphaFoldDB; Q5RZ65; -.
DR SMR; Q5RZ65; -.
DR STRING; 7955.ENSDARP00000094251; -.
DR PaxDb; Q5RZ65; -.
DR Ensembl; ENSDART00000103475; ENSDARP00000094251; ENSDARG00000070480.
DR Ensembl; ENSDART00000181841; ENSDARP00000157253; ENSDARG00000070480.
DR GeneID; 335616; -.
DR KEGG; dre:335616; -.
DR CTD; 10551; -.
DR ZFIN; ZDB-GENE-050417-214; agr2.
DR eggNOG; ENOG502RYQ8; Eukaryota.
DR GeneTree; ENSGT00530000063273; -.
DR InParanoid; Q5RZ65; -.
DR OMA; VFAEHKD; -.
DR OrthoDB; 1382017at2759; -.
DR PhylomeDB; Q5RZ65; -.
DR TreeFam; TF321449; -.
DR PRO; PR:Q5RZ65; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 19.
DR Bgee; ENSDARG00000070480; Expressed in mucus secreting cell and 42 other tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR GO; GO:0060575; P:intestinal epithelial cell differentiation; IMP:ZFIN.
DR GO; GO:0060548; P:negative regulation of cell death; IBA:GO_Central.
DR GO; GO:0010811; P:positive regulation of cell-substrate adhesion; ISS:UniProtKB.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000250|UniProtKB:O95994"
FT CHAIN 21..171
FT /note="Anterior gradient protein 2 homolog"
FT /evidence="ECO:0000255"
FT /id="PRO_0000392577"
FT MOTIF 40..49
FT /note="Homodimer stabilization; interchain"
FT /evidence="ECO:0000250|UniProtKB:O95994"
FT MOTIF 55..62
FT /note="Homodimer stabilization; interchain"
FT /evidence="ECO:0000250|UniProtKB:O95994"
FT CONFLICT 12
FT /note="M -> V (in Ref. 3; AAI52145)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 171 AA; 19677 MW; 7D34810E38C0FC1A CRC64;
MLKGLLSVLL VMVALSSALG KPEKTTPKKE KEKRVPQTLS RGWGDQLIWA QTYEEALFWS
RSKNKPLMVI FHLEDCPHSQ ALKKAFAEDK EIQKLADEDF VILNLVYETT DKHLSPDGQY
VPRIIFVDPS MTVRADITGR YSNRMYAYEP ADMKLLLSNM QRALKFLKTE L
