ID   AGR2_PONAB              Reviewed;         175 AA.
AC   Q5R7P1;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Anterior gradient protein 2 homolog;
DE   Flags: Precursor;
GN   Name=AGR2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for MUC2 post-transcriptional synthesis and
CC       secretion. May play a role in the production of mucus by intestinal
CC       cells. Proto-oncogene that may play a role in cell migration, cell
CC       differentiation and cell growth (By similarity). Promotes cell adhesion
CC       (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:O95994}.
CC   -!- SUBUNIT: Monomer and homodimer. Interacts with LYPD3 and DAG1
CC       (alphaDAG1). Interacts with MUC2; disulfide-linked.
CC       {ECO:0000250|UniProtKB:O95994}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O95994}.
CC       Endoplasmic reticulum {ECO:0000250|UniProtKB:O88312}.
CC   -!- SIMILARITY: Belongs to the AGR family. {ECO:0000305}.
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DR   EMBL; CR860071; CAH92219.1; -; mRNA.
DR   RefSeq; NP_001127525.1; NM_001134053.1.
DR   AlphaFoldDB; Q5R7P1; -.
DR   BMRB; Q5R7P1; -.
DR   SMR; Q5R7P1; -.
DR   STRING; 9601.ENSPPYP00000019909; -.
DR   Ensembl; ENSPPYT00000020695; ENSPPYP00000019909; ENSPPYG00000017761.
DR   GeneID; 100174601; -.
DR   KEGG; pon:100174601; -.
DR   CTD; 10551; -.
DR   eggNOG; ENOG502RYQ8; Eukaryota.
DR   GeneTree; ENSGT00530000063273; -.
DR   HOGENOM; CLU_088048_1_1_1; -.
DR   InParanoid; Q5R7P1; -.
DR   OrthoDB; 1382017at2759; -.
DR   Proteomes; UP000001595; Chromosome 7.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR   GO; GO:0070254; P:mucus secretion; ISS:UniProtKB.
DR   GO; GO:0010811; P:positive regulation of cell-substrate adhesion; ISS:UniProtKB.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Endoplasmic reticulum; Proto-oncogene; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250|UniProtKB:O95994"
FT   CHAIN           21..175
FT                   /note="Anterior gradient protein 2 homolog"
FT                   /id="PRO_0000001039"
FT   REGION          21..40
FT                   /note="Required to promote cell adhesion"
FT                   /evidence="ECO:0000250|UniProtKB:O95994"
FT   MOTIF           45..54
FT                   /note="Homodimer stabilization; interchain"
FT                   /evidence="ECO:0000250|UniProtKB:O95994"
FT   MOTIF           60..67
FT                   /note="Homodimer stabilization; interchain"
FT                   /evidence="ECO:0000250|UniProtKB:O95994"
SQ   SEQUENCE   175 AA;  20013 MW;  F03CBDD5A640DA0E CRC64;
     MEKISVSAFL LLVALSYTLA RDTTVKPAAK KDTKDSRPKL PQTLSRGWGD QLIWTQTYEE
     ALYKSKTSNK PLMIIHHLDE CPHSQALKKV FAENKEIQKL AEQFVLLNLV YETTDKHLSP
     DGQYVPRIMF VDPSLTVRAD ITGRYSNRLY AYEPTDTALL LDNMKKALKL LKTEL