ID   AGR2_XENTR              Reviewed;         164 AA.
AC   Q28ID5;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Anterior gradient protein 2 {ECO:0000312|EMBL:CAJ82848.1};
DE   Flags: Precursor;
GN   Name=agr2 {ECO:0000312|EMBL:CAJ82848.1}; ORFNames=TNeu048m19.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:CAJ82848.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula {ECO:0000312|EMBL:CAJ82848.1};
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Monomer and homodimer. {ECO:0000250|UniProtKB:O95994}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255, ECO:0000305}. Endoplasmic
CC       reticulum {ECO:0000250|UniProtKB:O88312}.
CC   -!- SIMILARITY: Belongs to the AGR family. {ECO:0000255}.
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DR   EMBL; CR760462; CAJ82848.1; -; mRNA.
DR   RefSeq; NP_001016627.1; NM_001016627.3.
DR   RefSeq; XP_012820168.1; XM_012964714.2.
DR   AlphaFoldDB; Q28ID5; -.
DR   SMR; Q28ID5; -.
DR   STRING; 8364.ENSXETP00000049323; -.
DR   PaxDb; Q28ID5; -.
DR   GeneID; 549381; -.
DR   KEGG; xtr:549381; -.
DR   CTD; 10551; -.
DR   Xenbase; XB-GENE-971548; agr2.
DR   eggNOG; ENOG502RYQ8; Eukaryota.
DR   HOGENOM; CLU_088048_1_0_1; -.
DR   InParanoid; Q28ID5; -.
DR   OrthoDB; 1382017at2759; -.
DR   PhylomeDB; Q28ID5; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000025625; Expressed in neurula embryo and 6 other tissues.
DR   ExpressionAtlas; Q28ID5; differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0002162; F:dystroglycan binding; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR   GO; GO:0060548; P:negative regulation of cell death; IBA:GO_Central.
DR   GO; GO:0010811; P:positive regulation of cell-substrate adhesion; ISS:UniProtKB.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250|UniProtKB:O95994"
FT   CHAIN           21..164
FT                   /note="Anterior gradient protein 2"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000392580"
FT   MOTIF           34..43
FT                   /note="Homodimer stabilization; interchain"
FT                   /evidence="ECO:0000250|UniProtKB:O95994"
FT   MOTIF           49..56
FT                   /note="Homodimer stabilization; interchain"
FT                   /evidence="ECO:0000250|UniProtKB:O95994"
SQ   SEQUENCE   164 AA;  18682 MW;  562A9306A41963FE CRC64;
     METVLKTLFV LLVATSLTLA KDLPQATRVL QTLSRGWGDN LEWVQTYEEG LYKAKTENKP
     LILINHRNDC PHSLALKKAF AEHQGIQKLA EEFVLLNVVY DPTDKNLQLD GQYVPKVVFV
     DPSLVVRADL PGKYSNHQYT YEPADIDLLF ENMKKALILL KTEL