ID   AGR3_XENTR              Reviewed;         164 AA.
AC   Q6DJ58;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-MAR-2010, sequence version 2.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Anterior gradient protein 3 {ECO:0000312|EMBL:AAH75325.1};
DE   Flags: Precursor;
GN   Name=agr3 {ECO:0000312|EMBL:AAH75325.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAH75325.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=F6 {ECO:0000312|EMBL:AAH75325.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for calcium-mediated regulation of ciliary beat
CC       frequency in the airway. {ECO:0000250|UniProtKB:Q8R3W7}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q8TD06}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8TD06}.
CC   -!- SIMILARITY: Belongs to the AGR family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH75325.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC075325; AAH75325.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001006909.1; NM_001006908.1.
DR   RefSeq; XP_012820000.1; XM_012964546.2.
DR   AlphaFoldDB; Q6DJ58; -.
DR   SMR; Q6DJ58; -.
DR   STRING; 8364.ENSXETP00000049321; -.
DR   PaxDb; Q6DJ58; -.
DR   GeneID; 448756; -.
DR   KEGG; xtr:448756; -.
DR   CTD; 155465; -.
DR   Xenbase; XB-GENE-950741; agr3.
DR   eggNOG; ENOG502R72A; Eukaryota.
DR   HOGENOM; CLU_088048_1_0_1; -.
DR   InParanoid; Q6DJ58; -.
DR   OrthoDB; 1382017at2759; -.
DR   PhylomeDB; Q6DJ58; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000022793; Expressed in liver and 8 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0002162; F:dystroglycan binding; IBA:GO_Central.
DR   GO; GO:0060548; P:negative regulation of cell death; IBA:GO_Central.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endoplasmic reticulum; Reference proteome; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..164
FT                   /note="Anterior gradient protein 3"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000392581"
FT   MOTIF           161..164
FT                   /note="Prevents secretion from ER"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   164 AA;  19083 MW;  472CD32F57CE1792 CRC64;
     MYFPMIELTL VLLASSNLAM SVRKEIRAPQ TLSRGWGDDI SWVQTYEEGL YNAKKRNKPL
     MVIHHLEDCQ YCQALKKVFA ESDEAQTLAQ EQFIMLNLMH ETTDKNLSPD GQYVPRIMFI
     DPTLTVRADI TGRYSNRRYT YEPQDLPLLI ENMNKAIHLL QTEL