ID   ERG2_DICDI              Reviewed;         233 AA.
AC   Q55BU8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Protein erg2 homolog;
GN   Name=erg2; ORFNames=DDB_G0270356;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May function in lipid transport from the endoplasmic
CC       reticulum and be involved in a wide array of cellular functions
CC       probably through regulation of the biogenesis of lipid microdomains at
CC       the plasma membrane. May regulate calcium efflux at the endoplasmic
CC       reticulum (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}.
CC       Cell membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ERG2 family. {ECO:0000305}.
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DR   EMBL; AAFI02000005; EAL72528.1; -; Genomic_DNA.
DR   RefSeq; XP_646733.1; XM_641641.1.
DR   AlphaFoldDB; Q55BU8; -.
DR   SMR; Q55BU8; -.
DR   STRING; 44689.DDB0267016; -.
DR   PaxDb; Q55BU8; -.
DR   EnsemblProtists; EAL72528; EAL72528; DDB_G0270356.
DR   GeneID; 8617705; -.
DR   KEGG; ddi:DDB_G0270356; -.
DR   dictyBase; DDB_G0270356; erg2.
DR   eggNOG; KOG4143; Eukaryota.
DR   HOGENOM; CLU_085469_0_0_1; -.
DR   InParanoid; Q55BU8; -.
DR   OMA; LWATTRI; -.
DR   PhylomeDB; Q55BU8; -.
DR   PRO; PR:Q55BU8; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:dictyBase.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000247; F:C-8 sterol isomerase activity; ISS:dictyBase.
DR   GO; GO:0006696; P:ergosterol biosynthetic process; ISS:dictyBase.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR006716; ERG2_sigma1_rcpt-like.
DR   PANTHER; PTHR10868; PTHR10868; 1.
DR   Pfam; PF04622; ERG2_Sigma1R; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Endoplasmic reticulum; Lipid transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..233
FT                   /note="Protein erg2 homolog"
FT                   /id="PRO_0000328403"
FT   TOPO_DOM        1..23
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        45..93
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        115..233
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   233 AA;  26715 MW;  6FEE059D10DCA1D6 CRC64;
     MDYFKTLEIN NFNDYLNHLI QGNKVVIGTS ILGLVIAIFI FIKIKLMRCI ELDTKILHEC
     TKKGVGLPID EAFEAIHKEL IKHYPQFITA KRNWLLFNGG GAMGQMCVLH ASLSEYLIFY
     GTPLYSQGHS GRYLMDVYDF MIQGTTKQFF PGKFQSIDFP AGKFSYLPMM VAKGYCCEPN
     SWMLEYGRGV IPLALPYFLF SSIFVTLDIV PWISAVFYVG REVTKNLLIR RKI