ID   ERG6_MAGO7              Reviewed;         390 AA.
AC   P0CT10; A4R5U1; G4NGD4; Q5EN22;
DT   18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2013, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Sterol 24-C-methyltransferase;
DE            EC=2.1.1.41;
DE   AltName: Full=Delta(24)-sterol C-methyltransferase;
GN   Name=ERG6; ORFNames=MGG_04346;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
CC   -!- FUNCTION: Catalyzes the methyl transfer from S-adenosyl-methionine to
CC       the C-24 of zymosterol to form fecosterol. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-adenosyl-L-methionine + zymosterol = fecosterol + H(+) + S-
CC         adenosyl-L-homocysteine; Xref=Rhea:RHEA:21128, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17038, ChEBI:CHEBI:18252, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789; EC=2.1.1.41;
CC   -!- PATHWAY: Steroid metabolism; ergosterol biosynthesis; ergosterol from
CC       zymosterol: step 1/5.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. Erg6/SMT family. {ECO:0000255|PROSITE-ProRule:PRU01022}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CM001236; EHA47091.1; -; Genomic_DNA.
DR   RefSeq; XP_003719458.1; XM_003719410.1.
DR   AlphaFoldDB; P0CT10; -.
DR   SMR; P0CT10; -.
DR   STRING; 318829.MGG_04346T0; -.
DR   EnsemblFungi; MGG_04346T0; MGG_04346T0; MGG_04346.
DR   GeneID; 2677539; -.
DR   KEGG; mgr:MGG_04346; -.
DR   VEuPathDB; FungiDB:MGG_04346; -.
DR   eggNOG; KOG1269; Eukaryota.
DR   HOGENOM; CLU_039068_5_3_1; -.
DR   OMA; NTFDKVY; -.
DR   OrthoDB; 661953at2759; -.
DR   UniPathway; UPA00768; UER00760.
DR   Proteomes; UP000009058; Chromosome 6.
DR   GO; GO:0003838; F:sterol 24-C-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR041698; Methyltransf_25.
DR   InterPro; IPR030384; MeTrfase_SMT.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR013705; Sterol_MeTrfase_C.
DR   Pfam; PF13649; Methyltransf_25; 1.
DR   Pfam; PF08498; Sterol_MT_C; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS51685; SAM_MT_ERG6_SMT; 1.
PE   3: Inferred from homology;
KW   Lipid biosynthesis; Lipid metabolism; Methyltransferase;
KW   Reference proteome; S-adenosyl-L-methionine; Steroid biosynthesis;
KW   Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transferase.
FT   CHAIN           1..390
FT                   /note="Sterol 24-C-methyltransferase"
FT                   /id="PRO_0000124794"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   390 AA;  43036 MW;  4442B9609B8DA9D5 CRC64;
     MSKQQHPSSK TQITRRRDTA DMTFEQVLHK GSSANMGGLS SMLGKDREAS KTAVDQYFRH
     WDGKTAKTET TKVREERKAD YATLTRQYYN LVTDFYEYGW GQSFHFCTFA PGETFASAIT
     RYEHTLAHRI GIKKGMKVLD IGCGVGGPAR QIAKFTGANI TGITINEYQV ERARRYAEME
     GYGAGEQLKF VQGDFMALPF EKETFDAVYS IEATVHAPKL EDVYKQIFNV LKPGGIFGLY
     EWVMTDAYDE NDPHHKEIRF GIEHGGGIAN LQTAQTAIAA IKAAGFELLE SEDLADNSDR
     APWYWPLGGN AWQYASTFGD ILSTFTMTPA GRAIAHTVLG VVESIGLVPP GTKKTADSLS
     TTAAALVAGG KEGLFTPMFL MVARKPVAKE