ID   ERG6_YARLI              Reviewed;         381 AA.
AC   Q6C2D9;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Sterol 24-C-methyltransferase;
DE            EC=2.1.1.41;
DE   AltName: Full=Delta(24)-sterol C-methyltransferase;
GN   Name=ERG6; OrderedLocusNames=YALI0F08701g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Catalyzes the methyl transfer from S-adenosyl-methionine to
CC       the C-24 of zymosterol to form fecosterol. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-adenosyl-L-methionine + zymosterol = fecosterol + H(+) + S-
CC         adenosyl-L-homocysteine; Xref=Rhea:RHEA:21128, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17038, ChEBI:CHEBI:18252, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789; EC=2.1.1.41;
CC   -!- PATHWAY: Steroid metabolism; ergosterol biosynthesis; ergosterol from
CC       zymosterol: step 1/5.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. Erg6/SMT family. {ECO:0000255|PROSITE-ProRule:PRU01022}.
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DR   EMBL; CR382132; CAG77980.1; -; Genomic_DNA.
DR   RefSeq; XP_505173.1; XM_505173.1.
DR   AlphaFoldDB; Q6C2D9; -.
DR   SMR; Q6C2D9; -.
DR   STRING; 4952.CAG77980; -.
DR   ChEMBL; CHEMBL3308968; -.
DR   PRIDE; Q6C2D9; -.
DR   EnsemblFungi; CAG77980; CAG77980; YALI0_F08701g.
DR   GeneID; 2908368; -.
DR   KEGG; yli:YALI0F08701g; -.
DR   VEuPathDB; FungiDB:YALI0_F08701g; -.
DR   HOGENOM; CLU_039068_5_3_1; -.
DR   InParanoid; Q6C2D9; -.
DR   OMA; ISNMCKV; -.
DR   UniPathway; UPA00768; UER00760.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005811; C:lipid droplet; IEA:EnsemblFungi.
DR   GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR   GO; GO:0003838; F:sterol 24-C-methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0006696; P:ergosterol biosynthetic process; IBA:GO_Central.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0016126; P:sterol biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR013216; Methyltransf_11.
DR   InterPro; IPR030384; MeTrfase_SMT.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR013705; Sterol_MeTrfase_C.
DR   Pfam; PF08241; Methyltransf_11; 1.
DR   Pfam; PF08498; Sterol_MT_C; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS51685; SAM_MT_ERG6_SMT; 1.
PE   3: Inferred from homology;
KW   Lipid biosynthesis; Lipid metabolism; Methyltransferase;
KW   Reference proteome; S-adenosyl-L-methionine; Steroid biosynthesis;
KW   Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transferase.
FT   CHAIN           1..381
FT                   /note="Sterol 24-C-methyltransferase"
FT                   /id="PRO_0000124798"
SQ   SEQUENCE   381 AA;  42703 MW;  0EE23241B436B147 CRC64;
     MSSNIKLAQK DYKGDKEFAA ALHGKEGHKK HGLGAVMSKN KDAQAAAVEG FFRNWGDKDR
     SKIEDADEQG RIEDYAGLTK HYYNLVTDFY EYGWGSSFHF SRYYKGEAFR QATARHEHYL
     AYKMGIQPGM KVLDVGCGVG GPAREIARFT GANIVGLNNN DYQVERGTHY SEVQGFGDQV
     TYVKGDFMQM DFPDNSFDAV YAIEATVHAP VLEGVYSEIF RVLKPGGVFG VYEWVMTDEY
     DESNPEHRDI CYGIEKGDGI PKMYKREVAV KALENVGFDI EYQEDLAADD AEVPWYYPLA
     GEWKYVQSLN DIVTIGRTSR LGRMVTMNVI GALEKIGLAP QGSRQVTEAL EDAAVNLVAG
     GKKKLFTPMM LFVSRKPEDK N