AGRA1_HUMAN
ID AGRA1_HUMAN Reviewed; 560 AA.
AC Q86SQ6; A5HL16; A6NG50; Q5T234; Q86SN7; Q96JJ9;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 3.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Adhesion G protein-coupled receptor A1 {ECO:0000303|PubMed:25713288};
DE AltName: Full=G-protein coupled receptor 123;
GN Name=ADGRA1 {ECO:0000312|HGNC:HGNC:13838}; Synonyms=GPR123, KIAA1828;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=12565841; DOI=10.1016/s0006-291x(03)00026-3;
RA Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C.,
RA Schioeth H.B.;
RT "There exist at least 30 human G-protein-coupled receptors with long
RT Ser/Thr-rich N-termini.";
RL Biochem. Biophys. Res. Commun. 301:725-734(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RC TISSUE=Brain;
RA Bonner T.I., Kauffman D., Nagle J.W., Sloger M.;
RT "Complete coding sequence of human GPR123.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=11347906; DOI=10.1093/dnares/8.2.85;
RA Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 8:85-95(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 94-465.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
RN [6]
RP NOMENCLATURE.
RX PubMed=25713288; DOI=10.1124/pr.114.009647;
RA Hamann J., Aust G., Arac D., Engel F.B., Formstone C., Fredriksson R.,
RA Hall R.A., Harty B.L., Kirchhoff C., Knapp B., Krishnan A., Liebscher I.,
RA Lin H.H., Martinelli D.C., Monk K.R., Peeters M.C., Piao X., Promel S.,
RA Schoneberg T., Schwartz T.W., Singer K., Stacey M., Ushkaryov Y.A.,
RA Vallon M., Wolfrum U., Wright M.W., Xu L., Langenhan T., Schioth H.B.;
RT "International union of basic and clinical pharmacology. XCIV. Adhesion G
RT protein-coupled receptors.";
RL Pharmacol. Rev. 67:338-367(2015).
RN [7]
RP VARIANT [LARGE SCALE ANALYSIS] ILE-38 (ISOFORM 1).
RX PubMed=18987736; DOI=10.1038/nature07485;
RA Ley T.J., Mardis E.R., Ding L., Fulton B., McLellan M.D., Chen K.,
RA Dooling D., Dunford-Shore B.H., McGrath S., Hickenbotham M., Cook L.,
RA Abbott R., Larson D.E., Koboldt D.C., Pohl C., Smith S., Hawkins A.,
RA Abbott S., Locke D., Hillier L.W., Miner T., Fulton L., Magrini V.,
RA Wylie T., Glasscock J., Conyers J., Sander N., Shi X., Osborne J.R.,
RA Minx P., Gordon D., Chinwalla A., Zhao Y., Ries R.E., Payton J.E.,
RA Westervelt P., Tomasson M.H., Watson M., Baty J., Ivanovich J., Heath S.,
RA Shannon W.D., Nagarajan R., Walter M.J., Link D.C., Graubert T.A.,
RA DiPersio J.F., Wilson R.K.;
RT "DNA sequencing of a cytogenetically normal acute myeloid leukaemia
RT genome.";
RL Nature 456:66-72(2008).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=3;
CC IsoId=Q86SQ6-3; Sequence=Displayed;
CC Name=1;
CC IsoId=Q86SQ6-1; Sequence=VSP_040208, VSP_040209;
CC Name=2;
CC IsoId=Q86SQ6-2; Sequence=VSP_040207;
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB47457.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY181241; AAO27353.1; -; mRNA.
DR EMBL; EF536972; ABQ08572.1; -; mRNA.
DR EMBL; AB058731; BAB47457.1; ALT_INIT; mRNA.
DR EMBL; AL445199; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY255564; AAO85076.1; -; mRNA.
DR CCDS; CCDS41580.1; -. [Q86SQ6-3]
DR CCDS; CCDS76362.1; -. [Q86SQ6-2]
DR RefSeq; NP_001077378.1; NM_001083909.2. [Q86SQ6-3]
DR RefSeq; NP_001278014.1; NM_001291085.1. [Q86SQ6-2]
DR RefSeq; XP_005252752.1; XM_005252695.1.
DR AlphaFoldDB; Q86SQ6; -.
DR BioGRID; 124075; 3.
DR IntAct; Q86SQ6; 1.
DR MINT; Q86SQ6; -.
DR STRING; 9606.ENSP00000376384; -.
DR ChEMBL; CHEMBL4523885; -.
DR GlyGen; Q86SQ6; 1 site.
DR iPTMnet; Q86SQ6; -.
DR PhosphoSitePlus; Q86SQ6; -.
DR BioMuta; ADGRA1; -.
DR DMDM; 313104230; -.
DR MassIVE; Q86SQ6; -.
DR PaxDb; Q86SQ6; -.
DR PeptideAtlas; Q86SQ6; -.
DR PRIDE; Q86SQ6; -.
DR ProteomicsDB; 69613; -. [Q86SQ6-3]
DR ProteomicsDB; 69614; -. [Q86SQ6-1]
DR ProteomicsDB; 69615; -. [Q86SQ6-2]
DR Antibodypedia; 48655; 70 antibodies from 21 providers.
DR DNASU; 84435; -.
DR Ensembl; ENST00000392606.2; ENSP00000376383.2; ENSG00000197177.16. [Q86SQ6-2]
DR Ensembl; ENST00000392607.8; ENSP00000376384.3; ENSG00000197177.16. [Q86SQ6-3]
DR GeneID; 84435; -.
DR KEGG; hsa:84435; -.
DR MANE-Select; ENST00000392607.8; ENSP00000376384.3; NM_001083909.3; NP_001077378.1.
DR UCSC; uc001llw.3; human. [Q86SQ6-3]
DR CTD; 84435; -.
DR DisGeNET; 84435; -.
DR GeneCards; ADGRA1; -.
DR HGNC; HGNC:13838; ADGRA1.
DR HPA; ENSG00000197177; Tissue enriched (brain).
DR MIM; 612302; gene.
DR neXtProt; NX_Q86SQ6; -.
DR OpenTargets; ENSG00000197177; -.
DR PharmGKB; PA134910893; -.
DR VEuPathDB; HostDB:ENSG00000197177; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000160175; -.
DR HOGENOM; CLU_008933_0_0_1; -.
DR InParanoid; Q86SQ6; -.
DR OMA; MHEEDAF; -.
DR OrthoDB; 31536at2759; -.
DR PhylomeDB; Q86SQ6; -.
DR TreeFam; TF331206; -.
DR PathwayCommons; Q86SQ6; -.
DR SignaLink; Q86SQ6; -.
DR BioGRID-ORCS; 84435; 7 hits in 1071 CRISPR screens.
DR ChiTaRS; ADGRA1; human.
DR GeneWiki; GPR123; -.
DR GenomeRNAi; 84435; -.
DR Pharos; Q86SQ6; Tbio.
DR PRO; PR:Q86SQ6; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q86SQ6; protein.
DR Bgee; ENSG00000197177; Expressed in right frontal lobe and 64 other tissues.
DR Genevisible; Q86SQ6; HS.
DR GO; GO:0098978; C:glutamatergic synapse; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; TAS:GDB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0014069; C:postsynaptic density; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; TAS:GDB.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:GDB.
DR GO; GO:0007165; P:signal transduction; NAS:UniProtKB.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR Pfam; PF00002; 7tm_2; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..560
FT /note="Adhesion G protein-coupled receptor A1"
FT /id="PRO_0000070337"
FT TOPO_DOM 1..19
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 20..40
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..53
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 54..74
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..84
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 85..105
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 135..155
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..175
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 176..196
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..257
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 258..278
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..284
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 285..305
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 306..560
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT REGION 210..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..224
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..97
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11347906"
FT /id="VSP_040207"
FT VAR_SEQ 1
FT /note="M -> MRGHGNHSRLKSRCASLGNVHHHQAQMAHGAHCRGGRTPQSPDSRGP
FT TAGGHTRGRWTYRPIEALINVSFPGAKGGRTAEGEPSWAWVFRSGYLQRQALPGLPVST
FT RVAACWWQHHPGRDSGFLGPGFIDLLREEPSGRADGKAAAQKTGRLYLFPTFLGNKLPE
FT AADSFGEIASGNSVIFTSVLQSSHPPGTPPPSARKPSPGAAMLVCEETLELGAQGCWGS
FT TSPRGQAVSLVGGPTAGGSRLGGAGCTMGLLMALQARRPRDGTWADPRRCSRAVEGSGL
FT TRAALVSPGPSGVEEDTRREGCVLVGSWRSSTHRSRVLIINTPSGRTPWSQGSLGSTGR
FT YNQTRAPGSQQQGLCSDAALHEDFVPEPTPAFFQYPPQAFSKTKVRDLGRGGLYAFSKE
FT EKVSEAQRVEAYETHGLGLSTGRQNPVPSPCKPGCVCQGLALDAEAWPRHPGRRPCAAK
FT EACLGPPGCSGELSLPEEEGIAPGAATAAPAWVPHGRVSRFLTVKLFTYVTMYQCKQER
FT ILRLCISGESGRYVRRSRFRNFAALMVSTGVPGVLQLGARPLRGGGHPYGDSQAGKVVE
FT WRAGDRASGLSAGERRFLSQSELQTWPRTPHCVGKKVPQPVGAADLAPDTSLCRKEGSS
FT ASRSCRPGPGHLTRREEDSFRQLAFPRFEEVTFPPLTAAERAPSVHGGHSLASQGLVLA
FT GRTRSVASGGKQELSGPLAACIPTQ (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:12565841"
FT /id="VSP_040208"
FT VAR_SEQ 167
FT /note="Missing (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:12565841"
FT /id="VSP_040209"
FT VARIANT 183
FT /note="A -> S (in dbSNP:rs34915504)"
FT /id="VAR_055931"
FT VARIANT 214
FT /note="Q -> L (in dbSNP:rs34679676)"
FT /id="VAR_055932"
FT CONFLICT 560
FT /note="V -> VW (in Ref. 1; AAO27353)"
FT /evidence="ECO:0000305"
FT VARIANT Q86SQ6-1:38
FT /note="T -> I (in an acute myeloid leukemia, somatic
FT mutation; dbSNP:rs181856403)"
FT /evidence="ECO:0000305"
FT /id="VAR_082826"
SQ SEQUENCE 560 AA; 60885 MW; 1529EA836A679C5C CRC64;
MDLKTVLSLP RYPGEFLHPV VYACTAVMLL CLLASFVTYI VHQSAIRISR KGRHTLLNFC
FHAALTFTVF AGGINRTKYP ILCQAVGIVL HYSTLSTMLW IGVTARNIYK QVTKKAPLCL
DTDQPPYPRQ PLLRFYLVSG GVPFIICGVT AATNIRNYGT EDEDTAYCWM AWEPSLGAFY
GPAAIITLVT CVYFLGTYVQ LRRHPGRRYE LRTQPEEQRR LATPEGGRGI RPGTPPAHDA
PGASVLQNEH SFQAQLRAAA FTLFLFTATW AFGALAVSQG HFLDMVFSCL YGAFCVTLGL
FVLIHHCAKR EDVWQCWWAC CPPRKDAHPA LDANGAALGR AACLHSPGLG QPRGFAHPPG
PCKMTNLQAA QGHASCLSPA TPCCAKMHCE PLTADEAHVH LQEEGAFGHD PHLHGCLQGR
TKPPYFSRHP AEEPEYAYHI PSSLDGSPRS SRTDSPPSSL DGPAGTHTLA CCTQGDPFPM
VTQPEGSDGS PALYSCPTQP GREAALGPGH LEMLRRTQSL PFGGPSQNGL PKGKLLEGLP
FGTDGTGNIR TGPWKNETTV
