ID   ERGI1_DANRE             Reviewed;         290 AA.
AC   Q4V8Y6;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Endoplasmic reticulum-Golgi intermediate compartment protein 1;
DE   AltName: Full=ER-Golgi intermediate compartment 32 kDa protein;
DE            Short=ERGIC-32;
GN   Name=ergic1; Synonyms=ergic32; ORFNames=zgc:114085;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possible role in transport between endoplasmic reticulum and
CC       Golgi. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum-Golgi
CC       intermediate compartment membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ERGIC family. {ECO:0000305}.
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DR   EMBL; BC097146; AAH97146.1; -; mRNA.
DR   RefSeq; NP_001025133.1; NM_001029962.1.
DR   AlphaFoldDB; Q4V8Y6; -.
DR   SMR; Q4V8Y6; -.
DR   STRING; 7955.ENSDARP00000105911; -.
DR   PaxDb; Q4V8Y6; -.
DR   GeneID; 567774; -.
DR   KEGG; dre:567774; -.
DR   CTD; 57222; -.
DR   ZFIN; ZDB-GENE-050913-75; ergic1.
DR   eggNOG; KOG2667; Eukaryota.
DR   InParanoid; Q4V8Y6; -.
DR   PhylomeDB; Q4V8Y6; -.
DR   PRO; PR:Q4V8Y6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR   InterPro; IPR045888; Erv.
DR   InterPro; IPR012936; Erv_C.
DR   InterPro; IPR039542; Erv_N.
DR   PANTHER; PTHR10984; PTHR10984; 1.
DR   Pfam; PF07970; COPIIcoated_ERV; 1.
DR   Pfam; PF13850; ERGIC_N; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; ER-Golgi transport; Glycoprotein; Golgi apparatus;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..290
FT                   /note="Endoplasmic reticulum-Golgi intermediate compartment
FT                   protein 1"
FT                   /id="PRO_0000087022"
FT   TOPO_DOM        1..27
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..254
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        276..290
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        74
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   290 AA;  32529 MW;  D33AFE3679F5D976 CRC64;
     MSFDVRRFDI YRKVPKDLTQ PTYTGAFISI CCCVFMLFLF LSELTGFIAT EIVNELYVDD
     PDKDSGGKID VSLNISLPNL HCDLVGLDIQ DEMGRHEVGH IENSMKVPLN NGHGCRFEGE
     FSINKVPGNF HVSTHSATAQ PQSPDMTHII HKLAFGAKLQ VQHVQGAFNA LGGADRLQSN
     ALASHDYILK IVPTVYEELG GKQRFSYQYT VANKEYVAYS HTGRIIPAIW FRYDLSPITV
     KYTERRRPFY RFITTICAII GGTFTVAGII DSCIFTASEA WKKIQIGKMS