ID   ERGI1_XENLA             Reviewed;         290 AA.
AC   Q6NS19;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Endoplasmic reticulum-Golgi intermediate compartment protein 1;
DE   AltName: Full=ER-Golgi intermediate compartment 32 kDa protein;
DE            Short=ERGIC-32;
GN   Name=ergic1; Synonyms=ergic32;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possible role in transport between endoplasmic reticulum and
CC       Golgi. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum-Golgi
CC       intermediate compartment membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ERGIC family. {ECO:0000305}.
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DR   EMBL; BC070532; AAH70532.1; -; mRNA.
DR   RefSeq; NP_001084786.1; NM_001091317.1.
DR   AlphaFoldDB; Q6NS19; -.
DR   SMR; Q6NS19; -.
DR   DNASU; 431823; -.
DR   GeneID; 431823; -.
DR   KEGG; xla:431823; -.
DR   CTD; 431823; -.
DR   Xenbase; XB-GENE-947916; ergic1.S.
DR   OMA; SYQYTYA; -.
DR   OrthoDB; 1318747at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 431823; Expressed in egg cell and 18 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR   InterPro; IPR045888; Erv.
DR   InterPro; IPR012936; Erv_C.
DR   InterPro; IPR039542; Erv_N.
DR   PANTHER; PTHR10984; PTHR10984; 1.
DR   Pfam; PF07970; COPIIcoated_ERV; 1.
DR   Pfam; PF13850; ERGIC_N; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; ER-Golgi transport; Glycoprotein; Golgi apparatus;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..290
FT                   /note="Endoplasmic reticulum-Golgi intermediate compartment
FT                   protein 1"
FT                   /id="PRO_0000087025"
FT   TOPO_DOM        1..26
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..254
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        276..290
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        74
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   290 AA;  32533 MW;  E721A30A03F0D0A6 CRC64;
     MPFDFRRFDI YRKVPKDLTQ PTYTGAIISI CCCLFITFLF LSELTGFIAN EIVNELYVDD
     PDKDSGGKID VTLNVTLPNL PCEVVGLDIQ DEMGRHEVGH IDNSMKIPIN NAYGCRFEGL
     FSINKVPGNF HVSTHSAIAQ PANPDMRHII HKLSFGNTLQ VDNIHGAFNA LGGADKLASK
     ALESHDYVLK IVPTVYEDLN GKQQFSYQYT VANKAYVAYS HTGRVVPAIW FRYDLSPITV
     KYTERRQPMY RFITTVCAII GGTFTVAGIL DSFIFTASEA WKKIQLGKMQ