ID   ERGI2_DANRE             Reviewed;         376 AA.
AC   Q7T2D4;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Endoplasmic reticulum-Golgi intermediate compartment protein 2;
GN   Name=ergic2; ORFNames=zgc:64005;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possible role in transport between endoplasmic reticulum and
CC       Golgi. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate
CC       compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Golgi apparatus, cis-Golgi network membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic
CC       reticulum membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ERGIC family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC054593; AAH54593.1; -; mRNA.
DR   RefSeq; NP_956701.1; NM_200407.1.
DR   AlphaFoldDB; Q7T2D4; -.
DR   STRING; 7955.ENSDARP00000068141; -.
DR   PaxDb; Q7T2D4; -.
DR   Ensembl; ENSDART00000073651; ENSDARP00000068141; ENSDARG00000051936.
DR   Ensembl; ENSDART00000180223; ENSDARP00000156218; ENSDARG00000051936.
DR   GeneID; 393378; -.
DR   KEGG; dre:393378; -.
DR   CTD; 51290; -.
DR   ZFIN; ZDB-GENE-040426-1331; ergic2.
DR   eggNOG; KOG2667; Eukaryota.
DR   GeneTree; ENSGT00530000063113; -.
DR   HOGENOM; CLU_034705_4_1_1; -.
DR   InParanoid; Q7T2D4; -.
DR   OMA; TYQYSVK; -.
DR   OrthoDB; 1318747at2759; -.
DR   PhylomeDB; Q7T2D4; -.
DR   TreeFam; TF317192; -.
DR   PRO; PR:Q7T2D4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 25.
DR   Bgee; ENSDARG00000051936; Expressed in muscle tissue and 21 other tissues.
DR   ExpressionAtlas; Q7T2D4; baseline and differential.
DR   GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR   InterPro; IPR045888; Erv.
DR   InterPro; IPR012936; Erv_C.
DR   InterPro; IPR039542; Erv_N.
DR   PANTHER; PTHR10984; PTHR10984; 1.
DR   Pfam; PF07970; COPIIcoated_ERV; 1.
DR   Pfam; PF13850; ERGIC_N; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..376
FT                   /note="Endoplasmic reticulum-Golgi intermediate compartment
FT                   protein 2"
FT                   /id="PRO_0000239386"
FT   TOPO_DOM        1..33
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        55..318
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        319..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        340..376
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   376 AA;  42590 MW;  7737119DBE2D0D7F CRC64;
     MRRLNKKKAL NFVRELDAFP KVPESYVETT ASGGTVSLLA FTAMALLAFF EFFVYRDTWM
     KYEYEVDKDF TSKLRINIDI TVAMRCQFVG ADVLDLAETM VASDGLVYEP VVFDLSPQQR
     LWHRTLLLIQ GRLREEHSLQ DVLFKNVMKG SPTALPPRED DPNQPLNACR IHGHLYVNKV
     AGNFHITVGK AIPHPRGHAH LAALVSHETY NFSHRIDHLS FGEEIPGILN PLDGTEKVSA
     DHNQMFQYFI TIVPTKLQTY KVYADTHQYS VTERERVINH AAGSHGVSGI FMKYDISSLM
     VKVTEQHMPF WQFLVRLCGI IGGIFSTTGM LHNLVGFCVD VVCCRFKLGV YKPKSMSDFD
     GQINSLTPLL SENAEQ