AGRA1_MOUSE
ID AGRA1_MOUSE Reviewed; 578 AA.
AC Q8C4G9; Q8CC05;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Adhesion G protein-coupled receptor A1;
DE AltName: Full=G-protein coupled receptor 123;
GN Name=Adgra1 {ECO:0000312|MGI:MGI:1277167}; Synonyms=Gpr123;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=17212699; DOI=10.1111/j.1471-4159.2006.04281.x;
RA Lagerstrom M.C., Rabe N., Haitina T., Kalnina I., Hellstrom A.R.,
RA Klovins J., Kullander K., Schioth H.B.;
RT "The evolutionary history and tissue mapping of GPR123: specific CNS
RT expression pattern predominantly in thalamic nuclei and regions containing
RT large pyramidal cells.";
RL J. Neurochem. 100:1129-1142(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in CNS.
CC {ECO:0000269|PubMed:17212699}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily. {ECO:0000305}.
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DR EMBL; AK082207; BAC38439.1; -; mRNA.
DR EMBL; AK034188; BAC28624.1; -; mRNA.
DR EMBL; AC107822; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466531; EDL17867.1; -; Genomic_DNA.
DR CCDS; CCDS40171.1; -.
DR RefSeq; NP_803420.2; NM_177469.3.
DR AlphaFoldDB; Q8C4G9; -.
DR IntAct; Q8C4G9; 1.
DR STRING; 10090.ENSMUSP00000026548; -.
DR iPTMnet; Q8C4G9; -.
DR PhosphoSitePlus; Q8C4G9; -.
DR SwissPalm; Q8C4G9; -.
DR PaxDb; Q8C4G9; -.
DR PRIDE; Q8C4G9; -.
DR ProteomicsDB; 281956; -.
DR Antibodypedia; 48655; 70 antibodies from 21 providers.
DR DNASU; 52389; -.
DR Ensembl; ENSMUST00000026548; ENSMUSP00000026548; ENSMUSG00000025475.
DR GeneID; 52389; -.
DR KEGG; mmu:52389; -.
DR UCSC; uc009kgb.1; mouse.
DR CTD; 84435; -.
DR MGI; MGI:1277167; Adgra1.
DR VEuPathDB; HostDB:ENSMUSG00000025475; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000160175; -.
DR HOGENOM; CLU_020720_1_0_1; -.
DR InParanoid; Q8C4G9; -.
DR OMA; RCWWACC; -.
DR OrthoDB; 31536at2759; -.
DR PhylomeDB; Q8C4G9; -.
DR TreeFam; TF331206; -.
DR BioGRID-ORCS; 52389; 3 hits in 74 CRISPR screens.
DR PRO; PR:Q8C4G9; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8C4G9; protein.
DR Bgee; ENSMUSG00000025475; Expressed in facial nucleus and 87 other tissues.
DR Genevisible; Q8C4G9; MM.
DR GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0014069; C:postsynaptic density; IDA:SynGO.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR Pfam; PF00002; 7tm_2; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 2: Evidence at transcript level;
KW Membrane; Receptor; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..578
FT /note="Adhesion G protein-coupled receptor A1"
FT /id="PRO_0000433253"
FT TOPO_DOM 1..22
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 23..43
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..87
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 88..108
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..178
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 179..199
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 200..262
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 263..283
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..289
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 290..310
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT REGION 216..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 446
FT /note="F -> C (in Ref. 1; BAC28624)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 578 AA; 63497 MW; 75101095C2CB4787 CRC64;
MTQWDLKTVL SLPQYPGEFL HPVVYACTAV MLLCLLASVI TYILHQSAIR ISRKGRHALL
NFCFHAALTF TVFAGGINRT QHPILCQAVG IALHYSTLST MLWIGVTARN IYKQVTKKAL
PCPGADQPPY PKQPLLRFYL ISGGVPFIIC GVTAATNIRN YGTEDEDVAY CWMAWEPSLG
AFYGPAAFIA LVTCVYFLCT YVQLRRHPER RYELRERTEE QQRLAVPESG HRHGVRPGTP
PTCDALAASQ LQNEHSFKAQ LRAAAFTLFL FTATWTFGAL AVSQGHFLDM IFSCLYGAFC
VTLGLFVLIH HCAKREDVWQ CWWSCCPSRG DTSTTKPGAH PTLDANGDAL GHTACLQDSP
CPGKLRGFGH PPASHCKMTN LQAAQGHVSC LSPATPCCAK MHCEQLMEEE AAHIHMAEED
VYPHDPHLHD PHLHRCLKGR TKSHYFSRHQ AAAAEREYAY HIPSSLDGSP HSSRSESPTS
SLEGPMGMHT LACCAQADPF PMVSQPEGGD TSPGLYGCPP HLSPGPAHLE MLRRTQSLPF
GGPSQNGLLQ GDVREGLPFG TDGTGNIRTG PWKNETTV
