ID   ERGI2_MACFA             Reviewed;         377 AA.
AC   Q4R5C3;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Endoplasmic reticulum-Golgi intermediate compartment protein 2;
GN   Name=ERGIC2; ORFNames=QtrA-11873;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Temporal cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possible role in transport between endoplasmic reticulum and
CC       Golgi. {ECO:0000250}.
CC   -!- SUBUNIT: May form a heteromeric complex composed of ERGIC1, ERGIC2 and
CC       ERGIC3 (By similarity). Interacts with ERGIC3, the interaction is
CC       required for the stable expression of both proteins (By similarity).
CC       May interact with EEF1A1 (By similarity).
CC       {ECO:0000250|UniProtKB:Q96RQ1}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate
CC       compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Golgi apparatus, cis-Golgi network membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic
CC       reticulum membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Cycles between the endoplasmic reticulum and the Golgi.
CC   -!- SIMILARITY: Belongs to the ERGIC family. {ECO:0000305}.
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DR   EMBL; AB169621; BAE01702.1; -; mRNA.
DR   RefSeq; NP_001272299.1; NM_001285370.1.
DR   AlphaFoldDB; Q4R5C3; -.
DR   SMR; Q4R5C3; -.
DR   STRING; 9541.XP_005570525.1; -.
DR   GeneID; 101867003; -.
DR   CTD; 51290; -.
DR   eggNOG; KOG2667; Eukaryota.
DR   OrthoDB; 1318747at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR   InterPro; IPR045888; Erv.
DR   InterPro; IPR012936; Erv_C.
DR   InterPro; IPR039542; Erv_N.
DR   PANTHER; PTHR10984; PTHR10984; 1.
DR   Pfam; PF07970; COPIIcoated_ERV; 1.
DR   Pfam; PF13850; ERGIC_N; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW   Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..377
FT                   /note="Endoplasmic reticulum-Golgi intermediate compartment
FT                   protein 2"
FT                   /id="PRO_0000239383"
FT   TOPO_DOM        1..33
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        55..319
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        341..377
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   377 AA;  42478 MW;  DB2E6B9C1B979483 CRC64;
     MRRLNRKKTL SLVKELDAFP KVPESYVETS ASGGTVSLIA FTTMALLTIM EFSVYQDTWM
     KYEYEVDKDF SSKLRINIDI TVAMKCQYVG ADVLDLAETM VASADGLVYE PAVFDLSPQQ
     KEWQRMLQLT QSRLQEEHSL QDVIFKSAFK SASTALPPRE DDSSQSPDAC RIHGHLYVNK
     VAGNFHITVG KAIPHPRGHA HLAALVNHES YNFSHRIDHL SFGELVPAII NPLDGTEKIA
     IDHNQMFQYF ITVVPTKLHT YKISADTHQF SVTERERIIN HAAGSHGVSG IFMKYDLSSL
     MVTVTEEHMP FWQFFVRLCG IVGGIFSTTG MLHGIGKFIV EIICCRFRLG SYKPVNSVPF
     EDGHTDNHLP LLENNTH