ID   ERGI3_DANRE             Reviewed;         383 AA.
AC   Q803I2; Q498P7;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Endoplasmic reticulum-Golgi intermediate compartment protein 3;
GN   Name=ergic3; ORFNames=zgc:113959, zgc:55762;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=AB, and SJD;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possible role in transport between endoplasmic reticulum and
CC       Golgi. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate
CC       compartment membrane; Multi-pass membrane protein. Golgi apparatus,
CC       cis-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q803I2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q803I2-2; Sequence=VSP_019217;
CC   -!- SIMILARITY: Belongs to the ERGIC family. {ECO:0000305}.
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DR   EMBL; BC044474; AAH44474.1; -; mRNA.
DR   EMBL; BC100125; AAI00126.1; -; mRNA.
DR   RefSeq; NP_001028277.1; NM_001033105.1. [Q803I2-2]
DR   RefSeq; NP_957309.1; NM_201015.1. [Q803I2-1]
DR   AlphaFoldDB; Q803I2; -.
DR   SMR; Q803I2; -.
DR   STRING; 7955.ENSDARP00000055510; -.
DR   PaxDb; Q803I2; -.
DR   PRIDE; Q803I2; -.
DR   Ensembl; ENSDART00000055502; ENSDARP00000055501; ENSDARG00000038074. [Q803I2-1]
DR   Ensembl; ENSDART00000055511; ENSDARP00000055510; ENSDARG00000038074. [Q803I2-2]
DR   GeneID; 393990; -.
DR   KEGG; dre:393990; -.
DR   CTD; 51614; -.
DR   ZFIN; ZDB-GENE-040426-795; ergic3.
DR   eggNOG; KOG2667; Eukaryota.
DR   GeneTree; ENSGT00530000063113; -.
DR   HOGENOM; CLU_034705_1_0_1; -.
DR   InParanoid; Q803I2; -.
DR   OMA; IGNFHIA; -.
DR   OrthoDB; 1318747at2759; -.
DR   PhylomeDB; Q803I2; -.
DR   TreeFam; TF300739; -.
DR   PRO; PR:Q803I2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 6.
DR   Bgee; ENSDARG00000038074; Expressed in mature ovarian follicle and 27 other tissues.
DR   ExpressionAtlas; Q803I2; baseline and differential.
DR   GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR   InterPro; IPR045888; Erv.
DR   InterPro; IPR012936; Erv_C.
DR   InterPro; IPR039542; Erv_N.
DR   PANTHER; PTHR10984; PTHR10984; 1.
DR   Pfam; PF07970; COPIIcoated_ERV; 1.
DR   Pfam; PF13850; ERGIC_N; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Endoplasmic reticulum; ER-Golgi transport;
KW   Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..383
FT                   /note="Endoplasmic reticulum-Golgi intermediate compartment
FT                   protein 3"
FT                   /id="PRO_0000239390"
FT   TOPO_DOM        1..25
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..341
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        342..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        363..383
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          110..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         229
FT                   /note="V -> VHAVEI (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_019217"
SQ   SEQUENCE   383 AA;  43139 MW;  D087BD241244C0BB CRC64;
     MDALNKLKQF DAYPKTLEDF RIKTCGGATV TIISGLIMLI LFFSELQYYL TKEVHPELFV
     DTSRGDKLRI NIDVIFPHMP CAYLSIDAMD VAGEQQLDVE HNLFKQRLDK DGQPVTTEAE
     KHDLGKEEEG VFDPSTLDPD RCESCYGAET DDLKCCNTCD DVREAYRRRG WAFKTPDTIE
     QCKREGFSQK MQEQKNEGCQ VYGFLEVNKV AGNFHFAPGK SFQQSHVHVH DLQSFGLDNI
     NMTHFIKHLS FGKDYPGIVN PLDDTNVAAP QASMMYQYFV KIVPTIYVKG DGEVVKTNQF
     SVTRHEKIAN GLIGDQGLPG VFVLYELSPM MVKFTEKQRS FTHFLTGVCA IIGGVFTVAG
     LIDSLIYHSA RAIQKKIELG KAS