ID   ERGI3_DICDI             Reviewed;         383 AA.
AC   Q54DW2;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Probable endoplasmic reticulum-Golgi intermediate compartment protein 3;
GN   Name=ergic3; ORFNames=DDB_G0292002;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Possible role in transport between endoplasmic reticulum and
CC       Golgi. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate
CC       compartment membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Golgi apparatus, cis-Golgi network membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic
CC       reticulum membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Note=Cycles between the endoplasmic reticulum and the
CC       Golgi. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ERGIC family. {ECO:0000305}.
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DR   EMBL; AAFI02000187; EAL61357.1; -; Genomic_DNA.
DR   RefSeq; XP_629760.1; XM_629758.1.
DR   AlphaFoldDB; Q54DW2; -.
DR   SMR; Q54DW2; -.
DR   STRING; 44689.DDB0266379; -.
DR   PaxDb; Q54DW2; -.
DR   EnsemblProtists; EAL61357; EAL61357; DDB_G0292002.
DR   GeneID; 8628435; -.
DR   KEGG; ddi:DDB_G0292002; -.
DR   dictyBase; DDB_G0292002; ergic3.
DR   eggNOG; KOG2667; Eukaryota.
DR   HOGENOM; CLU_034705_1_0_1; -.
DR   InParanoid; Q54DW2; -.
DR   OMA; IGNFHIA; -.
DR   PhylomeDB; Q54DW2; -.
DR   PRO; PR:Q54DW2; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR   InterPro; IPR045888; Erv.
DR   InterPro; IPR012936; Erv_C.
DR   InterPro; IPR039542; Erv_N.
DR   PANTHER; PTHR10984; PTHR10984; 1.
DR   Pfam; PF07970; COPIIcoated_ERV; 1.
DR   Pfam; PF13850; ERGIC_N; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..383
FT                   /note="Probable endoplasmic reticulum-Golgi intermediate
FT                   compartment protein 3"
FT                   /id="PRO_0000327512"
FT   TOPO_DOM        1..26
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..347
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        348..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        369..383
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   383 AA;  42921 MW;  4F9560EBAD149A7C CRC64;
     MLISQLKKFD AYPKTVDDFR VKTYTGAIVS IIGGVFILWL FFSQVTLYFS TDIHHELFVD
     TTRGEKLKIN MDITFHHLPC AYLSLDAMDV SGEHQFDVAH NIFKKRLSPT GQPIIEAPPI
     REEEINKKES VKDNNDVVGC GSCYGAEDPS KGIGCCNTCE EVRVAYSKKG WGLDPSGIPQ
     CIREGFTKNL VEQNGEGCQV YGFILVNKVA GNFHFAPGKS FQQHHMHVHD LQPFKDGSFN
     VSHTINRLSF GNDFPGIKNP LDDVTKTEMV GVGMFQYFVK VVPTIYEGLN GNRIATNQYS
     VTEHYRLLAK KGEEPSGLPG LFFMYDLSPI MMKVSERGKS FASFLTNVCA IIGGVFTVFG
     IFDSFIYYST KNLQKKIDLG KTF