ID   ERGI3_XENLA             Reviewed;         389 AA.
AC   Q66KH2;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Endoplasmic reticulum-Golgi intermediate compartment protein 3;
GN   Name=ergic3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possible role in transport between endoplasmic reticulum and
CC       Golgi. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate
CC       compartment membrane; Multi-pass membrane protein. Golgi apparatus,
CC       cis-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ERGIC family. {ECO:0000305}.
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DR   EMBL; BC080394; AAH80394.1; -; mRNA.
DR   RefSeq; NP_001087591.1; NM_001094122.1.
DR   AlphaFoldDB; Q66KH2; -.
DR   SMR; Q66KH2; -.
DR   MaxQB; Q66KH2; -.
DR   DNASU; 447415; -.
DR   GeneID; 447415; -.
DR   KEGG; xla:447415; -.
DR   CTD; 447415; -.
DR   Xenbase; XB-GENE-17339049; ergic3.L.
DR   OMA; IGNFHIA; -.
DR   OrthoDB; 1318747at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 447415; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR   InterPro; IPR045888; Erv.
DR   InterPro; IPR012936; Erv_C.
DR   InterPro; IPR039542; Erv_N.
DR   PANTHER; PTHR10984; PTHR10984; 1.
DR   Pfam; PF07970; COPIIcoated_ERV; 1.
DR   Pfam; PF13850; ERGIC_N; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..389
FT                   /note="Endoplasmic reticulum-Golgi intermediate compartment
FT                   protein 3"
FT                   /id="PRO_0000239391"
FT   TOPO_DOM        1..25
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..347
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        348..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        369..389
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   389 AA;  44153 MW;  7AD9F38027801829 CRC64;
     METLHRLRQF DAYPKTLEDF RVKTCGGAVV TVISGLIMLI LFFSELQYYL TKEVYPELFV
     DKSRGDKLKI NIDVIFPHMP CAYLSIDAMD VAGEQQLDVE HNLFKQRLDL DKKPVTSEAD
     RHELGKSEEQ VVFDPKTLDP NRCESCYGAE TDDFSCCNSC DDVREAYRRK GWAFKTPDSI
     EQCKREGFSQ KMQEQKNEGC QVYGFLEVNK VAGNFHFAPG KSFQQSHVHV HAVEIHDLQS
     FGLDNINMTH EIKHLSFGKD YPGLVNPLDG TSIVAMQSSM MFQYFVKIVP TVYVKVDGEV
     LRTNQFSVTR HEKMTNGLIG DQGLPGVFVL YELSPMMVKF TEKHRSFTHF LTGVCAIIGG
     VFTVAGLIDS LIYYSTRAIQ KKIELGKAT