ID   ERGI3_XENTR             Reviewed;         384 AA.
AC   Q6NVS2;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Endoplasmic reticulum-Golgi intermediate compartment protein 3;
GN   Name=ergic3;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possible role in transport between endoplasmic reticulum and
CC       Golgi. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate
CC       compartment membrane; Multi-pass membrane protein. Golgi apparatus,
CC       cis-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ERGIC family. {ECO:0000305}.
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DR   EMBL; BC067932; AAH67932.1; -; mRNA.
DR   RefSeq; NP_001001226.1; NM_001001226.1.
DR   AlphaFoldDB; Q6NVS2; -.
DR   SMR; Q6NVS2; -.
DR   STRING; 8364.ENSXETP00000007942; -.
DR   PaxDb; Q6NVS2; -.
DR   DNASU; 407904; -.
DR   GeneID; 407904; -.
DR   KEGG; xtr:407904; -.
DR   CTD; 51614; -.
DR   Xenbase; XB-GENE-941877; ergic3.
DR   eggNOG; KOG2667; Eukaryota.
DR   InParanoid; Q6NVS2; -.
DR   OrthoDB; 1318747at2759; -.
DR   Proteomes; UP000008143; Chromosome 10.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR   InterPro; IPR045888; Erv.
DR   InterPro; IPR012936; Erv_C.
DR   InterPro; IPR039542; Erv_N.
DR   PANTHER; PTHR10984; PTHR10984; 1.
DR   Pfam; PF07970; COPIIcoated_ERV; 1.
DR   Pfam; PF13850; ERGIC_N; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..384
FT                   /note="Endoplasmic reticulum-Golgi intermediate compartment
FT                   protein 3"
FT                   /id="PRO_0000239392"
FT   TOPO_DOM        1..25
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..342
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        364..384
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   384 AA;  43621 MW;  C2D12F34AA08A34A CRC64;
     MESLHRLRQF DAYPKTLEDF RVKTCGGALV TVISGLIMLI LFFSELQYYL TKEIYPELFV
     DKSRGDKLKI NIDVIFPHMP CAYLSIDAMD VAGEQQLDVE HNLFKQRLDK DKKPVTSEAD
     RHELGKSEEH VVFDPKSLDP NRCESCYGAE TDDFSCCNTC DDVREAYRRR GWAFKTPDSI
     EQCKREGFSQ KMQEQKNEGC QVYGFLEVNK VAGNFHFAPG KSFQQSHVHV HDLQSFGLDN
     INMTHEIRHL SFGRDYPGLV NPLDGSSVAA MQSSMMFQYF VKIVPTVYVK VDGEVLRTNQ
     FSVTRHEKMT NGLIGDQGLP GVFVLYELSP MMVKLTEKHR SFTHFLTGVC AIIGGVFTVA
     GLIDSLVYYS TRAIQKKIEL GKAT