ID   ERG_CHICK               Reviewed;         478 AA.
AC   Q90837;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=Transcriptional regulator Erg;
GN   Name=ERG;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Spleen;
RX   PubMed=7605748; DOI=10.1016/0925-4773(94)00322-e;
RA   Dhordain P., Dewitte F., Desbiens X., Stehelin D., Duterque-Coquillaud M.;
RT   "Mesodermal expression of the chicken erg gene associated with
RT   precartilaginous condensation and cartilage differentiation.";
RL   Mech. Dev. 50:17-28(1995).
CC   -!- FUNCTION: Acts as a transcriptional activator.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Expressed in mesoderm- and, to a lesser extent, in
CC       ectoderm-derived tissues.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR   EMBL; X77159; CAA54404.1; -; mRNA.
DR   PIR; S60754; S60754.
DR   RefSeq; NP_989611.1; NM_204280.1.
DR   AlphaFoldDB; Q90837; -.
DR   BMRB; Q90837; -.
DR   SMR; Q90837; -.
DR   STRING; 9031.ENSGALP00000029713; -.
DR   PaxDb; Q90837; -.
DR   Ensembl; ENSGALT00000053128; ENSGALP00000049471; ENSGALG00000016058.
DR   GeneID; 374146; -.
DR   KEGG; gga:374146; -.
DR   CTD; 2078; -.
DR   VEuPathDB; HostDB:geneid_374146; -.
DR   eggNOG; KOG3806; Eukaryota.
DR   GeneTree; ENSGT00940000160662; -.
DR   HOGENOM; CLU_045216_0_1_1; -.
DR   InParanoid; Q90837; -.
DR   PhylomeDB; Q90837; -.
DR   TreeFam; TF350537; -.
DR   PRO; PR:Q90837; -.
DR   Proteomes; UP000000539; Chromosome 1.
DR   Bgee; ENSGALG00000016058; Expressed in lung and 12 other tissues.
DR   ExpressionAtlas; Q90837; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; PTHR11849; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..478
FT                   /note="Transcriptional regulator Erg"
FT                   /id="PRO_0000204105"
FT   DOMAIN          113..199
FT                   /note="PNT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT   DNA_BIND        310..390
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT   REGION          34..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          73..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          242..303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        257..284
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   478 AA;  53913 MW;  8DFDB243ED8623A7 CRC64;
     MASTIKEALS VVSEDQSLFE CAYGSPHLAK TEMTASSSSE YGQTSKMSPR VPQQDWLSQP
     PARVTIKMEC NPNQVNGSRN SPDDCSVAKG GKMVSSSDNV GMNYGSYMEE KHIPPPNMTT
     NERRVIVPAD PTLWSTDHVR QWLEWAVKEY GLPDVDILLF QNIDGKELCK MTKDDFQRLT
     PSYNADILLS HLHYLRETPL PHLTSDDVDK ALQNSPRLMH ARNTGGATFI FPNTSVYPEA
     TQRITTRPDL PYEQARRSAW TSHSHPTQSK ATQPSSSTVP KTEDQRPQLD PYQILGPTSS
     RLANPGSGQI QLWQFLLELL SDSSNSNCIT WEGTNGEFKM TDPDEVARRW GERKSKPNMN
     YDKLSRALRY YYDKNIMTKV HGKRYAYKFD FHGIAQALQP HPPESSMYKY PSDLPYMSSY
     HAHPQKMNFV APHPPALPVT SSSFFAAPNP YWNSPTGGIY PNTRLPAAHM PSHLGTYY